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Авторизация |
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Voit E. — Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists |
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Предметный указатель |
Lewis, D.C. 409 479
Liang, S. 62 63 480 489
Liao, J.C. 157 472
Liddel, G.U. 315 480
Liebman, M.N. 64 483
Life cycle 293 315
Ligand 15—16
Lightfoot, E.N. 129 209 482
Limit cycle 114 118 119 125 126 219 409 448
Linear algebra 173 191 209 252 391 406 407 426
Linear algebra, determinants 430—434
Linear algebra, inverse matrices 437—439
Linear algebra, matrices 427—430
Linear algebra, systems of linear equations 434—437
Linear algebra, vectors 427—430
Linear differential equations 51 57 59
Linear function 46 56 69 71
Linear models 56 57
Linear pathways 23 95 129 130 131 136 137 141 142 157 193 204 206 210 219 220 399 405
Linear pathways with cross-activation 213—216
Linear pathways with feedback 212—216
Linear pathways, algebraic analysis 84 212—213
Linear pathways, computer simulation 115—119
Linear pathways, end-product inhibition 80—81
Linear pathways, equation constriction 78—81
Linear pathways, S-system 72 78—80 115—119 212—213
Linear pathways, steady-state evaluation 212—213
Linear pathways, surprise 115—119
Linear program/programming 285 286 287 289 405 408
Linear regression 148 149 150 173 176 186 191 414 419 451
Linear system 40 129 142 156 158 194 195 201 209
Linearization 414 417 419 420 421 425
Link matrix 257 258
Lipman, D.J. 18 470
Lipogenesis 62 284
Lipshutz, R.J. 17 480
Liver 133 148 150 151 153 208 297 327 335 365 369 370 374 398
Local minimum 174 179
Local property 140 228
Local stability 124—125 208—216 220 279 280 307 310 319 340 376
Lockhart, D.J. 17 18 480 493
Log gain see "Logarithmic gain"
Logarithmic amplification 222
Logarithmic coordinates 88 146 147 149 153 154 160 191 202 203 206 270 278 286 287 288 291 377 384 408 419 420 425 449
Logarithmic derivative 156 191 252 450
Logarithmic flux 71 146 147 148 156 190 253 325 390
Logarithmic gains (log gains) 122 126 144 190 191 219 222 223 242 247 249—251 283 292 296 307 311—314 320—325 342 353 362 380 389 390 393 395 397 398 402 405 408 456 464
Logarithmic gains (log gains) in glucose-6-phosphate pathway 123
Logarithmic gains (log gains) in glycolytic-glycogenolytic pathway model 376—377 384—388
Logarithmic gains (log gains) in GMA models 252—254
Logarithmic gains (log gains) of concentrations 235—241 252—253
Logarithmic gains (log gains) of fluxes 229—232 253—254 385—388
Logarithmic gains (log gains) of metabolites 224—229 384—385
Logarithmic gains (log gains), anaerobic fermentation pathway 280—282
Logarithmic gains (log gains), defined 121
Logarithmic gains (log gains), examples 226—229
Logarithmic gains (log gains), experimental measurements of 155—158
Logarithmic gains (log gains), S-system models 280—282
Logarithmic gains (log gains), sensitivity analysis with 224—233 252—254
Logarithmic gains (log gains), transition time and 232—233
Logistic growth 123 410
lognormal 139
Loomis, W.F. 294 480
Lopez, R. 18 489
Lotka, A.J. 4 5 46 480
Lowry, O.H. 159 480
Luenberger, D.G. 62 285 408 480
Luzzatto, L. 17 482
Lysine 31 32 443
Macro-mechanics 5
Macroscopic world 11
Magnesium 12 400 403
Mahler, H.R. 323 325 480
Majewski, R.A. 284 480
Malate 299 304 308 310 311 314 315 322 323 324 456
Malate dehydrogenase 300 310 311 313 320 322 323 325
Malic enzyme 310 313 322 324
Malonate 153
Maltose catabolic system 401
Maltsev, N. 15 16 487
MAP see "Maps biochemical"
Maps of cascaded mechanisms 86
Maps, arrows 23 25—27
Maps, biochemical 19 32 37 40 41 52 61 67 70 76 79 87 93 94 97 127 135 136 199 221 239 261 265 281 301 307 315 328 330 332 339 346 362 403
Maps, branched pathways 12 13 448
Maps, components and pools of components 23—24 25
Maps, constructing 14—15 17 23—28
Maps, database sources for 15—18
Maps, elements of 14
Maps, enzyme-catalyzed reactions 23
Maps, examples 28—31 54
Maps, gene 15
Maps, glycolysis 28—29
Maps, glycolytic-glycogenolytic pathway 365—368
Maps, interactions 24—25
Maps, linear pathways 115
Maps, modulations 24—25 26
Maps, nodes 25
Maps, purine biosynthesis 13
Maps, translation into equations 49 58 see
Maps, tricarboxylic acid cycle 297—298
Maps, zymogen activation 29—31
Maranas, C.D. 409 482
March, J. 411 488
Marginally stable 208 209 212 216
Marshall, R. 295 297 494
Martin, P.-G. 403 480
Martini, G. 17 480
Marzec, C.R. 18 470
Mason, R 17 482
Mass action ratio (Г) 162 169 372 373 374 398
Mass balance equations 91 92 93 94 267 371
Mass conservation 46 91 257 265 367
Mateo, E 365 369 374 398 489
Mateos, F.A. 355 470 477
Mathematical experiment 40 58 135 127—129
Mathematical representation 6 see biochemical" "Index "Notation"
Mathematical rigor 4 98 143 406 417
Mathematical tractability 7 41 59 330
Mathematically controlled experiment 58
Mathematically equivalent 91 137 147
Matrix 156 193 207 211 232 249 257 258 285 380 385 390 391 395 398 413 433 442 452 465
Matrix equations 61 64 200 201 202 203 204 205 218 227 231 238 250 251 253 256 284 381 386 429 430 431 434 435 436 438 441 468
Matrix identity 203 252 254 437 438 468
Matrix inverse/inversion 203—204 206 227 237 252 382 384 387 414 437—439 441
Matrix multiplication 386—387 388 428 429—430 432 438
Matrix notation 200 228 231 251 253
Matrix stoichiometric 16 61 251—252 256 284
Matrix transpose 427 428 434 467
Matrix, linear algebra 427—430
Maurer, H. 62 480
Mavrovouniotis, M.L. 61 64 171 470 480 483
Maximum velocity 2 162 274 374
Mayer, K. 18 481
Mazat, J.P. 323 483
McCusker, J.H. 18 479
McGarvey, P.B. 18 470
McKee, A.H.Z. 16 477
McKendrick, A.G. 220 478
McMillan, D. 17 477
Meaburn, G.M. 411 469
Measurable quantity 40—41
Mechanism 1 4 12 16 25 29 32 38 39 57 76 81 86 93 136 171 179 196 208 269 323 324 328 331 400 401 405 406 462
Meijer, A.J. 152 153 154 492
Melendez-Hevia, E. 216 232 246 284 365 369 373 374 389 390 398 471 476 480 489
Melian, J.S. 355 477
Meltzer, P. 18 473
Mende, W. 56 60 129 410 482
Mendelson, E. 62 481
Mental retardation 327 328 341
| Menten, L.E. 172 479 481
Menten, M.L. 38 43 481
mercaptopicolinic acid 152
merge from file option 117
Merrick, J.M. 8 473
Metabolic control analysis (MCA) 60 83 148 245 246 249
Metabolic disease 345
Metabolic language 62
Metabolic maps 12 15 40 see biochemical"
Metabolic models 7—8 15 16 38 59 61
Metabolic reconstruction 16
Metabolic rules 59 62
Metabolism 1 4 15 56 98 149 223 249 288 294 295 313—315 320 322 323 326—330 332 335 338 341—343 345 356 358 364 369 399 405 407
Metabolism, carbohydrate 167 168 296 297 365
Metabolism, drug 133 134 137 141
Metabolite(s) in GMA models 254 255
Metabolite(s) in models 38
Metabolite(s), concentration 233—243 288—289 335—337
Metabolite(s), databases 15 61
Metabolite(s), degradation 77 78
Metabolite(s), graphic representation 20 21 26
Metabolite(s), intermediate 15 22 76
Metabolite(s), kinetic orders 255
Metabolite(s), logarithmic gain 224—229
Metabolite(s), pooling of 90
Metabolite(s), rate constants 254
Metabolite(s), sensitivity analysis with 224—229 233—243 254 255
Methionine 32 343
Methionine adenosyltransferase (MAT) 342 348
Method of controlled mathematical comparisons 114 407
Methylcobalamin (MeCbl) 32
Methyltetrahydrofolate 32
Methyltransferase apoenzyme 32
Metz, E. 361 473
Mewes, H.-W. 18 470 474 481
Meyer, C.L. 284 482
Meyer, E.E 18 470
Michaelis constants 2 145 161 162 169 335 368
Michaelis — Menten equation 75
Michaelis — Menten rate laws 37 38 42—43 74 75 83 144 146 159 160 246 295 296 297 361 406 418 419
Michaelis — Menten reaction 43 76 260 273 342
Michaelis, L. 38 43 481
Michaels, G.S. 63 493
Michal, G. 15 481
Micro-mechanics 5
Microarray 17 18 145
Microbial heat generation 23
Microscopic world 11
Middleton, R. 149 481
Migimatsu, H. 16 474
Mikhailova, N. 15 16 487
Miller, G.A. 3 481
mips 18
Mitochondria 148 151—154 187 248 297—298
Mittmann, M. 18 493
Miyazaki, S. 18 489
Mnemonic abbreviations 19 20
Modal analysis 129 209
Mode of regulation 39 401
Models see also "Biochemical system models"
Models, design 16 127—129 262 326 327 395
Models, structure 40 58 146 322 326 342 396 404—406 407 409
modifiers 21 39
Modulated branch points 87 89
Modulation/modulators 11—13 24—27 31 38 39 40 50 62 81 155 157—158 190 285 328 366 421
Moiety 274 330 331 346 349
Mold 167 293
Molecular biology 5 10 399
Molecular formulas 19 20
Molecular trafficking 171
Molecular Visualization Freeware 18—19
Monod, J. 271 275 481
Monte Carlo simulation 138—140 411
Montero, E 284 476
Morgenstern, O. 5 492
Morimoto, B.H. 343 470
Morphogenesis 294
Most likely situation 138
Motility 187 247 248 249
MPW Metabolic Pathway Database 15
mRNA 17 63
Mucopolysaccharide 293
Mueller, K.M. 407 481
Mullin, R. 149 488
Multi-enzymatic complexes 171
Multinomial system 59
Multivariate 235 424 425 426
Murray, J.D. 131 481
Muscle 86 365
Mutagenesis 284
Mutant 149
Mutation 17 109 222 384 401
Mycobacterium tuberculosis 8
Myxamoeba 293
N-acetylglutamate 152—153
NADH 27 135 165 166 167 262 263 264 274 283 288 300 322 324 456
Namath, A.E 18 479
National Center for Biotechnology Information 18
National Human Genome Research Institute 18
National Library of Medicine 8 18
Natural design 115 284
Needham, J. 56 481
Neet, K.E. 38 479
Neidhardt, EC. 401 481
Nelson, D.L. 15 479
Nematode sequence 8
Nenashev, V. 15 16 487
Neobiosynthesis 328
Net change 73 194
Net flux 25 91 92 162 163 168 169 184 185 315 316 317 457 458
Neter, J. 186 450 481
Neuhaus, H.E. 149 151 152 479
Neuron networks Boolean 63
Neuron networks metabolic 59
Newsholme, E.A. 365 367 368 369 370 372 373 374 398 481
Newton 173
Newton — Raphson search method 407
Newton's laws of physics 37
Ni, T.-C. 113 145 399 407 435 481
Nieto, V.G. 355 477
Niklasson, F. 146 149 150 472
Nishioka, T. 15 16 62 475
Nishizuka, T. 15 481
Nitrogen flow 14
Nitrogen, dietary 327
Node equations 48 298 299 301 304 317
nodes 25 64
Nomenclature, for biochemical systems 19—23
Nominal steady state 146 157 159 165 208 308 312
Non-competitive inhibitor 152
Non-trivial solution 198
Nonlinear estimation 173—174 176 179 291
Nonlinear regression 172 173 174 175 176 178 189
Nonlinearity 3—4 50—51 56 74 131 148 151 155 179 191 202 208 209 213 226 234 291 310 343 404 408 409 417 418 420 424 426
Nonoxidative pentose pathway 262
Normalization 257
Norman, G.R. 140 481
Norvaline 154
Notation see also "Arrows"
Notation, activation 14 27 55 349
Notation, dot 42 44
Notation, index 19 20 23 31 42 47 48 50 54 55 59 77 78 88 99 101 103 184 200 205 243 245 247 265 338 368 413 416 427 433
Nucleic acid 327 328
Nucleic Acids Research journal 15
Nucleotide 9 247 331 344 363
Numerical algorithms 8 44 66—67 68 172 173 406—407
Numerical implementation 79
Numerical steady-state solution 85 123 219 435
Nyhan, W.L. 343 482
O'Brien, R.J. 171 472
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