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Voit E. — Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists
Voit E. — Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists



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Название: Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists

Автор: Voit E.

Аннотация:

A true understanding of genetic and metabolic function and design is facilitated by mathematical and computational methods for analyzing biochemical systems. This hands-on reference teaches biochemists and molecular biologists the use of modern computational methods for the analysis of complex biomedical systems requiring a modest mathematical background. The book begins with representations of biochemical systems, provides guidelines for setting up models, details mathematical and computational methods of parameter estimation and model analysis, and connects to the modern literature with four detailed case studies. Every step is illustrated with examples and explored with accompanying PLAS software. The volume also features over 250 exercises with about one quarter fully or partially solved.


Язык: en

Рубрика: Computer science/

Статус предметного указателя: Готов указатель с номерами страниц

ed2k: ed2k stats

Год издания: 2000

Количество страниц: 550

Добавлена в каталог: 19.02.2014

Операции: Положить на полку | Скопировать ссылку для форума | Скопировать ID
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Предметный указатель
Lewis, D.C.      409 479
Liang, S.      62 63 480 489
Liao, J.C.      157 472
Liddel, G.U.      315 480
Liebman, M.N.      64 483
Life cycle      293 315
Ligand      15—16
Lightfoot, E.N.      129 209 482
Limit cycle      114 118 119 125 126 219 409 448
Linear algebra      173 191 209 252 391 406 407 426
Linear algebra, determinants      430—434
Linear algebra, inverse matrices      437—439
Linear algebra, matrices      427—430
Linear algebra, systems of linear equations      434—437
Linear algebra, vectors      427—430
Linear differential equations      51 57 59
Linear function      46 56 69 71
Linear models      56 57
Linear pathways      23 95 129 130 131 136 137 141 142 157 193 204 206 210 219 220 399 405
Linear pathways with cross-activation      213—216
Linear pathways with feedback      212—216
Linear pathways, algebraic analysis      84 212—213
Linear pathways, computer simulation      115—119
Linear pathways, end-product inhibition      80—81
Linear pathways, equation constriction      78—81
Linear pathways, S-system      72 78—80 115—119 212—213
Linear pathways, steady-state evaluation      212—213
Linear pathways, surprise      115—119
Linear program/programming      285 286 287 289 405 408
Linear regression      148 149 150 173 176 186 191 414 419 451
Linear system      40 129 142 156 158 194 195 201 209
Linearization      414 417 419 420 421 425
Link matrix      257 258
Lipman, D.J.      18 470
Lipogenesis      62 284
Lipshutz, R.J.      17 480
Liver      133 148 150 151 153 208 297 327 335 365 369 370 374 398
Local minimum      174 179
Local property      140 228
Local stability      124—125 208—216 220 279 280 307 310 319 340 376
Lockhart, D.J.      17 18 480 493
Log gain      see "Logarithmic gain"
Logarithmic amplification      222
Logarithmic coordinates      88 146 147 149 153 154 160 191 202 203 206 270 278 286 287 288 291 377 384 408 419 420 425 449
Logarithmic derivative      156 191 252 450
Logarithmic flux      71 146 147 148 156 190 253 325 390
Logarithmic gains (log gains)      122 126 144 190 191 219 222 223 242 247 249—251 283 292 296 307 311—314 320—325 342 353 362 380 389 390 393 395 397 398 402 405 408 456 464
Logarithmic gains (log gains) in glucose-6-phosphate pathway      123
Logarithmic gains (log gains) in glycolytic-glycogenolytic pathway model      376—377 384—388
Logarithmic gains (log gains) in GMA models      252—254
Logarithmic gains (log gains) of concentrations      235—241 252—253
Logarithmic gains (log gains) of fluxes      229—232 253—254 385—388
Logarithmic gains (log gains) of metabolites      224—229 384—385
Logarithmic gains (log gains), anaerobic fermentation pathway      280—282
Logarithmic gains (log gains), defined      121
Logarithmic gains (log gains), examples      226—229
Logarithmic gains (log gains), experimental measurements of      155—158
Logarithmic gains (log gains), S-system models      280—282
Logarithmic gains (log gains), sensitivity analysis with      224—233 252—254
Logarithmic gains (log gains), transition time and      232—233
Logistic growth      123 410
lognormal      139
Loomis, W.F.      294 480
Lopez, R.      18 489
Lotka, A.J.      4 5 46 480
Lowry, O.H.      159 480
Luenberger, D.G.      62 285 408 480
Luzzatto, L.      17 482
Lysine      31 32 443
Macro-mechanics      5
Macroscopic world      11
Magnesium      12 400 403
Mahler, H.R.      323 325 480
Majewski, R.A.      284 480
Malate      299 304 308 310 311 314 315 322 323 324 456
Malate dehydrogenase      300 310 311 313 320 322 323 325
Malic enzyme      310 313 322 324
Malonate      153
Maltose catabolic system      401
Maltsev, N.      15 16 487
MAP      see "Maps biochemical"
Maps of cascaded mechanisms      86
Maps, arrows      23 25—27
Maps, biochemical      19 32 37 40 41 52 61 67 70 76 79 87 93 94 97 127 135 136 199 221 239 261 265 281 301 307 315 328 330 332 339 346 362 403
Maps, branched pathways      12 13 448
Maps, components and pools of components      23—24 25
Maps, constructing      14—15 17 23—28
Maps, database sources for      15—18
Maps, elements of      14
Maps, enzyme-catalyzed reactions      23
Maps, examples      28—31 54
Maps, gene      15
Maps, glycolysis      28—29
Maps, glycolytic-glycogenolytic pathway      365—368
Maps, interactions      24—25
Maps, linear pathways      115
Maps, modulations      24—25 26
Maps, nodes      25
Maps, purine biosynthesis      13
Maps, translation into equations      49 58 see
Maps, tricarboxylic acid cycle      297—298
Maps, zymogen activation      29—31
Maranas, C.D.      409 482
March, J.      411 488
Marginally stable      208 209 212 216
Marshall, R.      295 297 494
Martin, P.-G.      403 480
Martini, G.      17 480
Marzec, C.R.      18 470
Mason, R      17 482
Mass action ratio (Г)      162 169 372 373 374 398
Mass balance equations      91 92 93 94 267 371
Mass conservation      46 91 257 265 367
Mateo, E      365 369 374 398 489
Mateos, F.A.      355 470 477
Mathematical experiment      40 58 135 127—129
Mathematical representation      6 see biochemical" "Index "Notation"
Mathematical rigor      4 98 143 406 417
Mathematical tractability      7 41 59 330
Mathematically controlled experiment      58
Mathematically equivalent      91 137 147
Matrix      156 193 207 211 232 249 257 258 285 380 385 390 391 395 398 413 433 442 452 465
Matrix equations      61 64 200 201 202 203 204 205 218 227 231 238 250 251 253 256 284 381 386 429 430 431 434 435 436 438 441 468
Matrix identity      203 252 254 437 438 468
Matrix inverse/inversion      203—204 206 227 237 252 382 384 387 414 437—439 441
Matrix multiplication      386—387 388 428 429—430 432 438
Matrix notation      200 228 231 251 253
Matrix stoichiometric      16 61 251—252 256 284
Matrix transpose      427 428 434 467
Matrix, linear algebra      427—430
Maurer, H.      62 480
Mavrovouniotis, M.L.      61 64 171 470 480 483
Maximum velocity      2 162 274 374
Mayer, K.      18 481
Mazat, J.P.      323 483
McCusker, J.H.      18 479
McGarvey, P.B.      18 470
McKee, A.H.Z.      16 477
McKendrick, A.G.      220 478
McMillan, D.      17 477
Meaburn, G.M.      411 469
Measurable quantity      40—41
Mechanism      1 4 12 16 25 29 32 38 39 57 76 81 86 93 136 171 179 196 208 269 323 324 328 331 400 401 405 406 462
Meijer, A.J.      152 153 154 492
Melendez-Hevia, E.      216 232 246 284 365 369 373 374 389 390 398 471 476 480 489
Melian, J.S.      355 477
Meltzer, P.      18 473
Mende, W.      56 60 129 410 482
Mendelson, E.      62 481
Mental retardation      327 328 341
Menten, L.E.      172 479 481
Menten, M.L.      38 43 481
mercaptopicolinic acid      152
merge from file option      117
Merrick, J.M.      8 473
Metabolic control analysis (MCA)      60 83 148 245 246 249
Metabolic disease      345
Metabolic language      62
Metabolic maps      12 15 40 see biochemical"
Metabolic models      7—8 15 16 38 59 61
Metabolic reconstruction      16
Metabolic rules      59 62
Metabolism      1 4 15 56 98 149 223 249 288 294 295 313—315 320 322 323 326—330 332 335 338 341—343 345 356 358 364 369 399 405 407
Metabolism, carbohydrate      167 168 296 297 365
Metabolism, drug      133 134 137 141
Metabolite(s) in GMA models      254 255
Metabolite(s) in models      38
Metabolite(s), concentration      233—243 288—289 335—337
Metabolite(s), databases      15 61
Metabolite(s), degradation      77 78
Metabolite(s), graphic representation      20 21 26
Metabolite(s), intermediate      15 22 76
Metabolite(s), kinetic orders      255
Metabolite(s), logarithmic gain      224—229
Metabolite(s), pooling of      90
Metabolite(s), rate constants      254
Metabolite(s), sensitivity analysis with      224—229 233—243 254 255
Methionine      32 343
Methionine adenosyltransferase (MAT)      342 348
Method of controlled mathematical comparisons      114 407
Methylcobalamin (MeCbl)      32
Methyltetrahydrofolate      32
Methyltransferase apoenzyme      32
Metz, E.      361 473
Mewes, H.-W.      18 470 474 481
Meyer, C.L.      284 482
Meyer, E.E      18 470
Michaelis constants      2 145 161 162 169 335 368
Michaelis — Menten equation      75
Michaelis — Menten rate laws      37 38 42—43 74 75 83 144 146 159 160 246 295 296 297 361 406 418 419
Michaelis — Menten reaction      43 76 260 273 342
Michaelis, L.      38 43 481
Michaels, G.S.      63 493
Michal, G.      15 481
Micro-mechanics      5
Microarray      17 18 145
Microbial heat generation      23
Microscopic world      11
Middleton, R.      149 481
Migimatsu, H.      16 474
Mikhailova, N.      15 16 487
Miller, G.A.      3 481
mips      18
Mitochondria      148 151—154 187 248 297—298
Mittmann, M.      18 493
Miyazaki, S.      18 489
Mnemonic abbreviations      19 20
Modal analysis      129 209
Mode of regulation      39 401
Models      see also "Biochemical system models"
Models, design      16 127—129 262 326 327 395
Models, structure      40 58 146 322 326 342 396 404—406 407 409
modifiers      21 39
Modulated branch points      87 89
Modulation/modulators      11—13 24—27 31 38 39 40 50 62 81 155 157—158 190 285 328 366 421
Moiety      274 330 331 346 349
Mold      167 293
Molecular biology      5 10 399
Molecular formulas      19 20
Molecular trafficking      171
Molecular Visualization Freeware      18—19
Monod, J.      271 275 481
Monte Carlo simulation      138—140 411
Montero, E      284 476
Morgenstern, O.      5 492
Morimoto, B.H.      343 470
Morphogenesis      294
Most likely situation      138
Motility      187 247 248 249
MPW Metabolic Pathway Database      15
mRNA      17 63
Mucopolysaccharide      293
Mueller, K.M.      407 481
Mullin, R.      149 488
Multi-enzymatic complexes      171
Multinomial system      59
Multivariate      235 424 425 426
Murray, J.D.      131 481
Muscle      86 365
Mutagenesis      284
Mutant      149
Mutation      17 109 222 384 401
Mycobacterium tuberculosis      8
Myxamoeba      293
N-acetylglutamate      152—153
NADH      27 135 165 166 167 262 263 264 274 283 288 300 322 324 456
Namath, A.E      18 479
National Center for Biotechnology Information      18
National Human Genome Research Institute      18
National Library of Medicine      8 18
Natural design      115 284
Needham, J.      56 481
Neet, K.E.      38 479
Neidhardt, EC.      401 481
Nelson, D.L.      15 479
Nematode sequence      8
Nenashev, V.      15 16 487
Neobiosynthesis      328
Net change      73 194
Net flux      25 91 92 162 163 168 169 184 185 315 316 317 457 458
Neter, J.      186 450 481
Neuhaus, H.E.      149 151 152 479
Neuron networks Boolean      63
Neuron networks metabolic      59
Newsholme, E.A.      365 367 368 369 370 372 373 374 398 481
Newton      173
Newton — Raphson search method      407
Newton's laws of physics      37
Ni, T.-C.      113 145 399 407 435 481
Nieto, V.G.      355 477
Niklasson, F.      146 149 150 472
Nishioka, T.      15 16 62 475
Nishizuka, T.      15 481
Nitrogen flow      14
Nitrogen, dietary      327
Node equations      48 298 299 301 304 317
nodes      25 64
Nomenclature, for biochemical systems      19—23
Nominal steady state      146 157 159 165 208 308 312
Non-competitive inhibitor      152
Non-trivial solution      198
Nonlinear estimation      173—174 176 179 291
Nonlinear regression      172 173 174 175 176 178 189
Nonlinearity      3—4 50—51 56 74 131 148 151 155 179 191 202 208 209 213 226 234 291 310 343 404 408 409 417 418 420 424 426
Nonoxidative pentose pathway      262
Normalization      257
Norman, G.R.      140 481
Norvaline      154
Notation      see also "Arrows"
Notation, activation      14 27 55 349
Notation, dot      42 44
Notation, index      19 20 23 31 42 47 48 50 54 55 59 77 78 88 99 101 103 184 200 205 243 245 247 265 338 368 413 416 427 433
Nucleic acid      327 328
Nucleic Acids Research journal      15
Nucleotide      9 247 331 344 363
Numerical algorithms      8 44 66—67 68 172 173 406—407
Numerical implementation      79
Numerical steady-state solution      85 123 219 435
Nyhan, W.L.      343 482
O'Brien, R.J.      171 472
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