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| Авторизация |
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| Voit E. — Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists |
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| Предметный указатель |
f-factor 210 211 214
Factorial 418
Fairen, V. 59 129 164 410 473 476
Faux, M.C. 171 473
Feedback, activation 198 206 220
Feedback, branched pathways with 111—115 125 126 202
Feedback, cascade with 86
Feedback, controls 13
Feedback, inhibition 3 4 14 32 57 80—82 113 115 126 157 176 208 220 243 256 279 329 334 405
Feedback, linear pathway with 212—216
Feedback, regulation 86 329 405
Feedforward activation 279
Feil, R. 149 151 152 479
Feldmann, H. 8 9 475
Fell, D.A. 38 60 62 83 86 147 148 149 156 157 161 163 172 223 245 249 284 473
Fermentation 2 260 261 273 275 285 290 292 399 408 see
Ferreira, A.E.N. 67 91 135 136 137 323 407 473 491
Fersht, A.R. 160 473
Fiechter, A. 272 479
Field, R.J. 293 494
Final time 45 80 84 103 104 105 117 378 458
Finish time 44 103
Firing transitions 64
First-order kinetic processes 44 53 65 145 176 276 295
First-order rate constant 308
Fitness 174 401 408
Fleischmann, R.D. 8 473
Flint, A. 149 492
Flint, H.J. 149 473
Floudas, C.A. 396 405 409 476
Flow of currents 48
flow of information 14
Flow of material 12—14 20 23 24 31 38 40 82 86 145 304
Flow, arrows 14 20 23 25 27 28—29 31 93 443
Flow, carbon 14
Flux(es) 151—154 158 160 164 165 170 171 183 223 233 246 248 250 260 261 267 281 282 285 290 291 303 304 310 311 322 336 340—344 346 354—357 361—363 368 373 376 379 397 408 445 447 see "Influxes"
Flux(es) as transformations 84—85
Flux(es) at branch points 17 82 119 176 184 288 314 315 323 369 391 393
Flux(es), aggregation of 82 83 87 91—92 119 288
Flux(es), arrows 25 26 27
Flux(es), back 25
Flux(es), changes in 40
Flux(es), conservation of 79 82 391
Flux(es), cycle 314 320
Flux(es), degradation 85 191
Flux(es), equivalence 73 130
Flux(es), feedback inhibition and 115 149
Flux(es), glycolytic-glycogenolytic pathway 385—388
Flux(es), GMA models 253—256
Flux(es), kinetic orders and 82 145 148 255—256
Flux(es), log gains 229—232 253—254 385—388
Flux(es), logarithmic 71 146 147 148 156 190 253 325 390
Flux(es), maximization of 286—289
Flux(es), metabolite changes and 62 70 74
Flux(es), net 25 91 92 162 163 168 169 184 185 315 316 317 457 458
Flux(es), parameter changes and 244—245
Flux(es), purine metabolism 337—338
Flux(es), rate constants 78—79 82 254—255
Flux(es), rates 42 78—79 254—255
Flux(es), relative changes in 73—75 147 148
Flux(es), reversal 25 92 405
Flux(es), secondary reactions and 129
Flux(es), sensitivity 229—232 244—245 253—256
Flux(es), size 17
Flux(es), smooth functions 70
Flux(es), steady state 73 119 130 146 147 287 337—338 370
Flux(es), stoichiometry of 83 191 288
Fly Nets 16
FlyBase Consortium 16 473
Fodor, S.P.A. 17 473 480
Forest 400 403
Formal language approach 59 62—64
Forward flux 25
Forward reaction 96 162 451
Fox, I.H. 359 473
Fractal kinetic orders 55
Fractal kinetics 406
Fractals 129
Franco, R. 216 232 251 315 323 327 373 389 390 471 473
Frank, P.M. 222 473
Franke, J. 315 473
Fredrickson, D.S. 12 13 17 327 328 360 488
Free energy 27
Frenkel, R.A. 38 474
frequency 110 117 125 409 449
Frequency-modulated Roessler oscillator 136
Frishman, D. 18 481
Fructose diphosphate 90
Fructose-2,6-biphosphate 367
Fructose-6-phosphate (F6P) 28 100 101 109 122 125 167 168 170 187 262 263 264 271 272 273—275 290 367 369 370 374 376 384 391 398
Fructose-l,6-diphosphatase 262
Fructose-l,6-diphosphate 273—275
Fruiting body 293
Fudge factors 58
Fuhrman, S. 63 480 493
Fujibuchi, W 15 16 62 474 475 482
Fujimori, S. 359 474
Fujiwara, S. 407 487
Fumarase 300 323 325
Fumarate (FUM) 188 298 299 304 307 308 309 310 319 320 324 451
Function(s) see also "Power-law functions"
Function(s) algebraic 2 42
Function(s) defined 42
Function(s) discrete 416 439
Function(s) explicit 417
Function(s) exponential 44
Function(s) linear 46
Function(s) monotone 57 417 439
Function(s) of functions 47
Function(s) of several variables 225 421—424 474
Function(s) of single variable 414—421
Function(s) rational 38
Function(s), change 42
Function(s), classification of 77 406 410
Function(s), continuous 417 439
Function(s), degradation 59
Function(s), general features of 414—417 421—424
Fung, E.T. 171 472
Futile cycle 262
Gaasterland, T. 15 487
Gain 37 97 125 205 215 262 282 291 315 387 391 see
Gain profile 229 313 321 323 324 328 403
Gain types 223
Galazzo, J.L. 187 260 261 268 269 270 273 474
Galibert, F. 8 9 475
Galilei, Galileo 55
Galimova, M. 15 16 487
Gallagher, R. 5 474
Game theory 5
Gamma (Г, mass action ratio) 162 169 372 373 374 398
Ganguly, S. 409 474
Garavelli, J.S. 18 470
Garcia, J. 246 478
Garfinkel, D. 2 5 38 40 172 469 471 474 479 481 483
Garnier, T. 8 471
Garrels, J.I. 16 477
Gas, S. 8 471
Gauss 173
Gavalas, G.R. 61 251 474
Gear method 200 444 445
Geigy A.G. 40 369 474
GenBank 18
Gene circuits 4 158—159 400 401—402
Gene expression 15 17—18 63 145 149 400 401 402
Gene regulation 4 18 62 86 158—159 179 400—402 407
Gene sequences 15—16
General mass action model and GMA system 76 85 94 95 97 105 112 126—128 144 159 165 188 194 200 219 241 260 272 275 277—281 288 290 291 324 325 328 333—335 338 339 342 344 346 347 350 351 353—361 363 364 405 407 410 444 445 455 459 461
General mass action model and GMA system, anaerobic fermentation pathway 265—268
General mass action model and GMA system, branch-point constraints 82—84
General mass action model and GMA system, canonical 65
| General mass action model and GMA system, computer simulations 103
General mass action model and GMA system, concentrations 252—253
General mass action model and GMA system, constrained systems 82—84 257—258
General mass action model and GMA system, degradation in 265 267 355 362 448
General mass action model and GMA system, dependent variables 77—78
General mass action model and GMA system, equation specification 76 77—78 82—83 265—268
General mass action model and GMA system, examples 256—257
General mass action model and GMA system, exercises 258—259
General mass action model and GMA system, fluxes 253—256
General mass action model and GMA system, kinetic orders 255—256
General mass action model and GMA system, logarithmic gains 252—254
General mass action model and GMA system, mathematical structure 59
General mass action model and GMA system, metabolite sensitivity 254—255
General mass action model and GMA system, power-law terms 77
General mass action model and GMA system, rate constants 254—255
General mass action model and GMA system, sensitivity analyses in 251—259
General mass action model and GMA system, terminology 251—252
General mass action model and GMA system, uses 60
General system theory 5
Genetic algorithm 174
Genetic grammar 62
Genetic language 62
Genetic manipulation 8 62 148
Genetic network 63
Genetic polymorphisms 17
Genetic rules 62
Genome sequences 8
Genomics comparative 8—9
Genomics functional 8—9
GenProtEC 16
Gentile, C. 18 479
George, D.G. 18 474
Gerber, G. 40 474
Gesteland, R. 8 9 472
Giacomello, A. 334 474
Giersch, C. 156 474
Ginesla, I. 315 323 471
Gingeras, T.R. 17 480
Glez-Alcon, C. 59 83 223 260 286 289 290 396 408 409 490
Global Properties 140
Global stability 208
Glucagon 151 152
Glucokinase 28 29 100 367 369 370 373 390 396
Gluconeogenesis 150 152
Glucose 6 24 28 29 40 100 108 120 122 167 168 187 188 261 262 264 268—270 280 282 285 294 296 299 365 366 367 369 370 378—380 386—389 393 397 398 415 421 422 462
Glucose formation 151 152
Glucose-6-phosphate (G6P) 17 24 28 100 101 125 126 162 167—171 187 188 261—264 267—269 290 365 366 368—370 373 374 379 380 384 385 393 397
Glucose-6-phosphate (G6P), degradation 110 167 271—273 278 391
Glucose-6-phosphate (G6P), metabolism 98—99 103—105 108—109
Glucose-6-phosphate (G6P), parameter sensitivities 122—123
Glucose-6-phosphate (G6P), steady-state values 120 121—122
Glucose-6-phosphate dehydrogenase 17
Glucose-l-phosphate (G1P) 28 100 101 103 107—109 122 295 366 367 369 370 372 373 377 378 384 393 397
Glutamate (GLU) 32 188 299 300 309 310 315 319 325 457
Glutamate dehydrogenase 300
Glutamate semialdehyde 32
Glutamic acid 12
Glutamine synthase 86
Glutamine synthetase 38—39
Glyceraldehyde 3-phosphate dehydrogenase (GAPD) 264 274 275 291
Glycerol 249 261 262 263 264 273 274 285 286 290
Glycogen 28 29 100 261 262 264 267 272 295 367 368 369 370 372 396 398
Glycogen phosphorolysis 366
Glycogen synthetase 187 271 272—273 291
Glycogenolysis 365 366 390
Glycolysis 22 28 29 90 187 228 229 238 243 365 366 372
Glycolytic-glycogenolytic pathway, algebraic analysis 365—398
Glycolytic-glycogenolytic pathway, branch point constraints 393—395
Glycolytic-glycogenolytic pathway, changes in dependent variables 377—378
Glycolytic-glycogenolytic pathway, changes in independent variables 378—379
Glycolytic-glycogenolytic pathway, consistency analysis 375—380
Glycolytic-glycogenolytic pathway, constraints 370—372
Glycolytic-glycogenolytic pathway, exercises 396—398
Glycolytic-glycogenolytic pathway, fluxes 385—388
Glycolytic-glycogenolytic pathway, kinetic orders 372—375 395
Glycolytic-glycogenolytic pathway, log gains 376—377 384—388
Glycolytic-glycogenolytic pathway, map construction 365—368
Glycolytic-glycogenolytic pathway, metabolites 384—385
Glycolytic-glycogenolytic pathway, parameter values 368—375 379—380
Glycolytic-glycogenolytic pathway, perturbations 377—380
Glycolytic-glycogenolytic pathway, precursor-product relationships 391—393
Glycolytic-glycogenolytic pathway, rate constants 375 390—395
Glycolytic-glycogenolytic pathway, robustness of model 375—380 379—380
Glycolytic-glycogenolytic pathway, S-system equations 375
Glycolytic-glycogenolytic pathway, sensitivities 376—377 390—395
Glycolytic-glycogenolytic pathway, steady-state data 368—370
Glycolytic-glycogenolytic pathway, steady-state equations 380—383
Glycolytic-glycogenolytic pathway, steady-state solution 375—376
Glycolytic-glycogenolytic pathway, symbolic steady-state analysis 380—395
Glycolytic-glycogenolytic pathway, transition times 389—390
Glycolytic-glycogenolytic pathway, unconstrained parameters 391
GMA model 60 76 82 83 94 103 127 128 144 165 188 251 267 268 272 277 278 280 288 291 325 335 338 342 351 353—357 359—363 405 444 461
GMA system 59 60 77 78 84 95 103 105 112 126 194 200 219 241 281 350 354 362 405 407 444 448 455 459
GMP reductase (GMPR) 334 348
GMP synthetase (GMPS) 348
Goffeau, A. 8 9 475
Gojobori, T. 1 8 489
Golaz, O. 9 493
Goldberg, D.E. 174 475
Goldenfeld, N. 3 475
Goldstein, J.L. 12 13 17 327 328 360 488
Gompertz function 220
Gompertz law 410
Gooley, A.A. 9 493
Gordon, S.V. 8 471
Goryanin, L 15 16 487
Goto, S. 15 16 62 474 475 482
Gottlieb, L. 149 151 152 479
Gout 327
Gradient-based search 174
Grammar 62
Graphical representation 6 11 311 416
Graphical representation of rate laws 16
Graphical representation, chemical structures 12—13
Graphical representation, databases 15—16
Graphical representation, directed graph 61 63
Graphical representation, enzymes 20—21 27
Graphical representation, exercises 31—36
Graphical representation, maps 12—19 23—31
Graphical representation, parameters 21—23
Graphical representation, PLAS solutions 107 108
Graphical representation, three-dimensional biomolecular structures 18—19
Graphical representation, variables 19—23
Green, S.B. 38 474
Gregg, J.H. 315 475
Gregory, R.B. 415 421 422 470
Gretchkin, Y. 15 16 487
Grivell, A.R. 415 421 422 470
Groen, A.K. 148 150 151 152 162 163 372 475
Grosveld, E 17 482
Growth 6 55 56 114 141 144 159 172 174 189 220 294 406 410 411 417
Growth, canonical modeling of 402—404
Growth, characteristics 7
Growth, logistic 123 124
Guanase 330
Guanine (Gua) 329 331 333 334 335 336 340 341 344 345 347 351 353 356 347 348 363
Guanine hydrolase (GUA) 334 348
Guanosine (Guo) 328 331 353
Guanosine diphosphate (GDP) 330 333 336 346 347 352
Guanosine monophosphate (GMP) 333 347
Guanosine triphosphate (GTP) 330 333 336 346 347 348 352
Guanylates 56 346
Guckenheimer, J. 208 209 475
Guerin, B. 323 483
Guideline 24 97 316 326
Guidelines for Exposure Assessment 140
Guierrez-Rios, R.M. 62 471
Gustafson, G.L. 294 295 475 494
Haemophilus influenzae 8
Halangk, W. 187 247 470
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