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Авторизация |
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Поиск по указателям |
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Wong S.S. — Chemistry of Protein Conjugation and Cross-Linking |
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Предметный указатель |
-adenosine triphosphatase (-ATPase) 223—224
-ATPase (-adenosine triphosphatase) 223—224
,-Bis (5'-pyridoxal)-diphosphate (Bis-PLP) 94
,-Bis (5'-pyridoxal)-polyphosphate 94
mechanism 10 12
,-Bis(((p-chlorophenyl)sulfonyl)methyi)-4-nitroacetophenone 159
,-Bis(((p-chlorophenyl)sulfonyl)methyl) acetophenone 159
,-Bis(((p-chlorophenyl)sulfonyl)methyl)-m-nitroacetophenone 159
,-Bis(((p-chlorophenyl)sulfonyl)methyl)-p-chloroacetophenone 159
,-Bis(((p-tolysulfonyl)methyl)-4-nitroacetopenone 159
,-Bis(((p-tolysulfonyl)methyl)-m-nitroacetophe-none 159
,-Bis((p-tolysufonrl)methyl)p-aminoacetophenone 160
,’-Dibromo-p-xylene sulfonic acid 114
-Amylase 309
-Haloacetates 23 42
-Haloacetyls 30—32 34
-Hydroxyadipaldehyde 93
-Naphthol-2,4-disulfonyl chloride 90
-Macroglobulin 228 269 279
-Galactosidase (GS) 248
-Galactosidase (GS) in immunoconjugate characterization 260
-Galactosidase (GS) in immunoconjugate preparation 209 210 255—257 259—260
-Galactosidase (GS), stability and 215
-Galactosidase (GS), thiolation and 20
-Lactoglobulin 15
-Lactoside 25
(4-Nitro-3-(1-chlorocarbonyloxyethyl)phenyl)methyl-3-(2-pyridyldithiopropionic acid) ester 279 283
(4-Nitro-3-(1-chlorocarbonyloxyethyl)phenyl)methyl-S-acetylthioic acid ester 278—279 283
(ABNA) Ethyl N-(5-azido-2-nitrobenzoyl)aminoacetimidate 170
1 -Diazoacetyl-1 -bromo-2-phenylethane 161
1,1-Bis(diazoacetyl)-2-phenylethane 53 124
1,2-Cyclohexanedione 42 43
1,2-Di(bromoacetyl)amino-3-phenylhydrazine 112
1,3-Bis(2-chloroethyl)-1-nitrosourea 115
1,3-Bis(trans-4-hydroxyhexyl)-1-nitrosourea 115
1,3-Dibromoacetone 111 121
1,4-Bis(bromomercuri)butane 105 106
1,4-ButadioldigIycidoxy ether 119
1,4-Butanediol diglycidyl ether (1,4-bis(2,3-epoxypropoxy)butane) 308
1,4-Dicanatobenzene 87
1,4-Phenylene diisothiocyanate 89
1,5-Diazidonaphthalene (DAN) 129
1,5-Dibromo-2,4-dinitrobenzene 86
1,5-Dichloro-2,4-dinitrobenzene 86
1,6-Diaminohexane 296
1,6-Hexamethylene diisocyanate (HMDI) 87
1,7-Diaminoheptane 296
1-(Aminooxy)-4-((3-nitro-2-pyridyl)dithio)but-2-ene 162 321
1-(Aminooxy)-4-((3-nitro-2-pyridyl)dithio)butane 161 321
1-Azido-5-naphthaleneisothiocyanate 172
1-Benzyl-3-(3-dimethylsminopropyl)carbodiimide (BDC) 196
1-Cyano-4-dimethylaminopyridinium tetrafluorborate 298
1-Cyclohexyl-3-(2-morpholinyl-(4)-ethyl)-carbodiim-ide metho-p-toluenesulfonate (CMC) 196
1-Cyclohexyl-3-(2-morphylinyl-(4)-ethyl) carbodiim-ide (CMC) 39 40 286
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) 196 260
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide in amination 23 25
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide in RNA-protein cross-linking 321
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide, carboxyl groups and 39 40
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide, contractile protein system and 226
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide, immunotoxins and 271—273 286
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide, membrane proteins and 240
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide, multi-subunit protein study with 223 224
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide, ribosomal protein arrangements and 225
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide methiodide 196
1-Ethyl-3-(4-azonia-4,4-dimethylpentyl)carbodiimide iodide (EAC) 196 199
1-Fluoro-2,4-dinitro-benzene 224
10,10'-Decamethylenebis(methanethiosulfonate) 107
2,2'-Bis(maleimidoethoxy)propane 110
2,2'-Dicarboxy-4,4'-azophenyldiisocyanate 88
2,2'-Dicarboxy-4,4'-azophenyldithioisocyanate 88
2,2'-Dicarboxy-4,4'-dibromoacetamidoazobenzene 113
2,2'-Dicarboxy-4,4'-diiodoacetamidoazobenzene 113
2,2'-Dicarboxy-6,6'-azophenyldiisocyanate 89
2,2'-Dithiobis-(succinimidyIpropionate) (DSP) 84
2,2-Bis(maleimidomethoxy)propane 111
2,3-Butanedione 42 43
2,4,5-Trichlorophenyl chlorocarbonate 303
2,4,5-Trichlorophenyl chloroformates 200
2,4,5-Trifluro-5-chloropyrimidine 308
2,4,6-Tri(ethyleneimino)-s-triazine 118
2,4,6-Trichloro-s-triazine 116
2,4-Dichloro-6(3'-methyl-4-aminoanilino)-s-triazine 116
2,4-Dichloro-6-(5'-sulfonic-acid-naphthaleneamino)-s-triazine 117
2,4-Dichloro-6-(sulfonic acid)-s-triazine 116
2,4-Dichloro-6-amino-s-triazine 116
2,4-Dichloro-6-methoxy-s-triazine 115 210
2,4-Dichloro-6-methoxytriazine 286
2,5-Hexanedione 95 101
2-(p-Nitrophenyl) allyltrimethylammonium iodine 159
2-(p-Nitrophenyl)allyl-4-nitro-3-carboxyphenylsulfide 158
2-Acetoxy-4-maleimidobenzoyl-chloride 157
2-Amino-4,6-dichloro-s-triazine 307
2-Bromoethylamine 23 25
2-Bromoethylmaleimide 158
2-Carboethylseleno-4-azido-2-nitrobenzoate 175
2-Carboxy-methylamino-4,6-dichloro-s-triazine 307
2-Carboxymethyloxy-4,6-dichloro-s-triazine 307
2-Chloro-4-maleimidobenzoyl-chloride 157
2-Cyanato-4-isothiocyanatotoluene 87
2-Diazo-3,3,3-trifluropropionyl chloride (DTPC) 172
2-Fluoro-1-methylpyridinium salt 305
2-Fluoro-N-methylpyridinium salt 306
2-Hydroxy-4-(N-maleimido)benzoylazide (HMB) 157
2-Hydroxy-5-nitrobenzyl bromide (HNBB) 42 44
2-Iminothiolane 95 103 251
2-Iminothiolane in ribosomal protein studies 224
2-Iminothiolane, immunotoxins and 268 269 273 275
2-Iminothiolane-modified anti-tissue plasminogen activator 130
2-lsocyanato-4-isothiocyanatotolulene 37
2-Mercaptoethanol 16 33 63 64 237
2-Mercaptoethylamine 16 248—249 251 254
2-Methoxy-2,4-dimethylglutaraldehyde 93
2-methoxy-4-nitrophenyl ether 184
2-Methyl-N’-benzenesulfonyl--bromoacetylquinone-diimide 162 183
2-Methylmaleic anhydride 66 278
2-Nitro-4-azidophenylsulfenyl chloride (NAPSCl) 174
2-Nitro-4-sulfonic acid-phenyl-6-maleimidocaproate (MAHNSA) 155 277
2-Nitro-5-thiobenzoate 7
2-Pyridyl disulfide 269 271
3'-Arylazido--alanine--azido-ATP 178
3'-Arylazido--alanine-8-azido ATP (di ATP) 224
3'-o-(3-(N-Azido-(2-nitrophenyl)amino)-propionyl)-8-azidoadenosine-5'-triphosphate 182
3,3'-Dithiobis(sulfosuccinimidylpropionate) (DTSSP) 85 310
3,3'-Dithiobis-(succinimidylpropionate) (DSP) 84
3,4,5,6-Tetrahydroxysuberimidate (THS) 80
3,4-Isopropylidene-1,2:5,6-dianhydromannitol 119
3,6-Bis(acetoxymercurimethyl)dioxane 106
3,6-Bis(chloromercurimethyl)dioxane 106
3,6-Bis(mercurimethyl) dioxane 60 63 105 106 259
3,6-Bis(nitromercurimethyl) dioxane 106
3-((2-Nitro-4-azidophenyl)-2-aminoethyldithio)-N-succinimidylpropionate (NAP-AEDSP) 168
3-(2-Pyridyldithio)propionate 271
3-(3-Acetylthiopropionyl)thiazolidine-2-thione 20 24
3-(3-p-Methoxybenzylthiopropionyl)thioazolidine-2-thione 20 24
3-(4-Azido-2-nitrobenzoylseleno)propionic acid (ANBSP) 66 175
3-Amino-4-methoxyphenylvinyl sulfone 187 188
3-Aminopropyltriethoxysilane 296
3-Methoxy-2,4-dimethylglutaraldehyde 101
3-Methoxydiphenylmethane-4,4'-diisocyanate 88
3-Methylglutaraldehyde 93 101
3-Nitrotyrosine 25
3-Oxy-2,2-bis((((2-((3-carboxy-4-mtrophenyl)diothio)ethyl)-amino)carbonyl)hexanyl)-4,4-dimethyloxazolidine 106
3-Oxy-2,2-bis(6-((N-succinimidyloxy)carbonyl)hexanyl)-4,4-dimethyloxazolidine 82
3-Oxy-2,2-bis(8-((N-succinimidyloxy)carbonyl)octanyl)-4,4-dimethyloxazolidine 82
3-Oxy-2,2-bis-(6-(((3-((N-succinimidyloxy)carbonyl)propyl)amino)carbonyl)hexanyl)-4,4-dimethyloxazolidine 83
4'-Aminomethyl-4,5',8-trimethylpsoralen (AMT) 319
4'-Hydroxymethyl-4,5'-8-trimethylpsoralen (HMT) 319
4,4'-Diaminodiphenylamine 125
4,4'-Diaminodiphenyldisulfide 125
4,4'-Diaminodiphenylmethane 300
| 4,4'-Diazidobiphenyl (DABP) 129
4,4'-Dithiobisphenylazide (DTPA) 129 175 239
4,4'-Dithiodipyridine 33 251
4,4'-Dithiostilbene-2,2'-disulfonate 227
4,5',8-Trimethylpsoralen (TMP) 319
4-(2,2-Bis((p-tolysulfonyl)methyl) acetyl)benzoic acid 160
4-(Bromoaminoethyl)-3-nitrophenylazide (BANPA) 173
4-(Iodoacetylamino)-3,4,5,6-tetrahydrophthalic anhydride 278
4-Azidoiodobenzene 69 171
4-Azidophenylglyoxal (APG) 180
4-Azidophenylmaleimide (APM) 177
4-Azidophenylsulfenyl chloride 178
4-Chloroacetylphenylmaleimide 157
4-Fluoro-3-nitrophenylazide 17 183
4-Maleimidobenzophenone 226
4-Maleimidobenzoylchloride 157
4-Pyridyldisulfide 271
4-Succinimidyloxycarbonyl--methyl--(2-pyridyldithio)toluene (SMPT) 271—272
5'(p-Fluorosulfonylbenzoyl)-8-azidoadenosine (FSBAzA) 179 188
5,5'-Dithiobis-(2-nitrobenzoic acid) (DTNB) see Ellman's reagent
5,5'-Pentamethylenebis(methanethiosulfonate) 107
5-((4,6-Dichloro-5-triazin-2-yl)amino)naphthalene-1-sulfonic acid 117
5-((4,6-Dichloro-s-triazin-2-yl)amino)fluorescein (5-DTAF) 117 122
5-(4,6-Dichloro-s-triazin-2-yl)-aminofluorescein diacetate 117
5-DTAF(5-((4,6-Dichloro-s-traizin-2-yl)amino)fluorescein) 117 122
5-Isothiocyanato-1-naphthalene azide 172
5-Thio-2-nitrobenzoate 181
6,6'-Hexamethylenebis(methanethiosulfonate) 107
8,8'-Octamethylenebis(methanethiosulfonate) 107
8-Azidoadenosine 188
8-Methoxypsoralen (8-MOP) 319
8-MOP (8-Methoxypsoralen) 319
ABC see Avidin-biotin complex
Abrin 268 269 272 277 279
Acetic acid 14
Acetimidate 97
Acetophenones 63 see
Acetyls, cleavage and 66—67
Acid anhydrides 31 37 see
Acid halides 37 57 see
Acid-label cross-linkers 278 281
Acrolein 163
Acrylonitrile 302—303
Actin 226
Active-site-directed reagents 1
Acyl azides, amino group reactions and 91—92 100—101 147
Acyl azides, carbohydrate prosthetic groups and 27
Acyl azides, photoactivatable cross-linking and 128 183
Acyl azides, protein immobilization and 300
Acyl chlorides 147 184
Acyl halides 38
Acyl hydrazides 300
Acylating agents see also Acylation; specific types
Acylating agents, amino groups and 37 87—92 99—101 147
Acylating agents, electrophilicity and 51
Acylating agents, tyrosine groups and 40
Acylation 10 11 see
Acylation in nucleophilic reactions 53—58
Adenine 188
Adenosine receptors 236
Adipaldehyde 93 101
Adipic acid dihydrazide 127 132—133
Adriamycin 267 279
Agarose 295—298 312
AGTC(W-(4-Azidobenzoyl-2-glycyl)-S-(2-thiopyridyl)cysteine) 175
Alanine 7
Aldehydes 35—37 101 296 299 see
Aliphatic side chains 7
Alkaline phosphatase (ALP) 248 254—255 260 320
Alkosilanes 296 see
Alkoxylamino groups 182
Alkyl azides 128 183
Alkyl halides 34 147 185
Alkylating agents see also Alkylation; specific types
Alkylating agents, amino group reactions and 34—37
Alkylating agents, electrophilicity and 51
Alkylating agents, methionine and 42
Alkylating agents, sulfhydryl group reactions and 111—119 121—122 147
Alkylation 11 see
Alkylation described 10
Alkylation, disguised reagents and 188
Alkylation, immunotoxins and 286
Alkylation, in amino groups 35 51 53 60
Alkylation, in carbohydrate prosthetic groups 27
Alkylation, in zero-length cross-linking 203
Alkylation, nucleophilic reactions and 51—55
Alkylchloroformate 307
ALP see Alkaline phosphatase
AMAS (N-Succinimidyl maleimidoacetate) 148
Amides 296 see
Amidines 37 see
Amination 23 25
Amino acid analysis 214
Amino acid side chains 60 188
Amino acid side chains, description of 7—8
Amino acid side chains, reactive 8—14
Amino group reagents 33—39
Amino group reagents, heterobifunctional 147—161 182
Amino group reagents, heterobifunctional, immunoconjugates and 251
Amino group reagents, heterobifunctional, protein immobilization and 310—312
Amino group reagents, homobifunctional 75—104
Amino group reagents, homobifunctional, acylating agents and 87—92 99—101
Amino group reagents, homobifunctional, aryl halides and 85—86 99
Amino group reagents, homobifunctional, bis-imidoesters and 75—81 98
Amino group reagents, homobifunctional, bis-N-succinimidyls and 81—85 98—99
Amino group reagents, homobifunctional, dialdehydes and 92—95 101
Amino group reagents, homobifunctional, diketones and 95 101
Amino group reagents, immunotoxins and 276—277
Amino group reagents, in immunoconjugate preparation 254 255 258 260
Amino groups 8 10 see
Amino groups, acylation and 53 57 58
Amino groups, alkylation and 35 51 53 60
Amino groups, cleavage and 66
Amino groups, conversion to carboxylic acids 16—17
Amino groups, conversion to sulfhydryl groups 17—20
Amino groups, photosensitive reagents anchored by 163—173 184—185
Amino groups, solid matrix activation of 296 299 300—302
Amino groups, thiol conversion to 23 25
Amino groups, tyrosine groups compared with 40
Aminooxypyridyldithio derivatives 182 see
Aminophenyl glycosides 27
Aminothiopyridine 182
Aminotyrosine 25 27
AMT (4'-Aminomethyl-4,5',8-trimethylpsoralen) 319
Analysis of cross-linked products 213—214
ANB-NOS (N-5-Azido-2-nitrobenzoyloxysuccin-imide) 164
ANBSP (3-(4-Azido-2-nitrobenzoylseleno)propionic acid) 66 175
Antibodies 130 258—259 see
Antigen-binding fragments (Fab) 248 254 256 258
Antigens 130 see
APB (p-Azidophenacyl bromide) 173 238
APG (4-Azidophenylglyoxal) 176
APM (4-Azidophenylmaleimide) 173
APTP (N-(4-Azidophenylthio)phthalimide) 58 61 174
Arginine group reagents 40—43 127 128
Arginine groups 7 8 11 13 see
Arrhenius equation 215 216
Artifacts of membrane cross-linking 234
Aryl azides 1 60—63 128 183 184
Aryl halides 31 35 36 54 85—86 99 147 184
Arylamine 312
Arylation 11 36
Arylazido-cystamine psoralens 320
Arylchloroformate 307
Arylsulfonyl fluorides 45
Asialofetuin 271
Asparaginase 228
Asparagine 8
Aspartic acid 7 8 10 11 13
Atrial natriuretic peptide (ANP) receptors 236
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