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Wong S.S. — Chemistry of Protein Conjugation and Cross-Linking
Wong S.S. — Chemistry of Protein Conjugation and Cross-Linking



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Название: Chemistry of Protein Conjugation and Cross-Linking

Автор: Wong S.S.

Аннотация:

University of Texas Health Science Center, Houston. Biochemistry - advanced research review.


Язык: en

Рубрика: Химия/

Статус предметного указателя: Готов указатель с номерами страниц

ed2k: ed2k stats

Год издания: 1993

Количество страниц: 352

Добавлена в каталог: 21.11.2006

Операции: Положить на полку | Скопировать ссылку для форума | Скопировать ID
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Предметный указатель
$F_1$-adenosine triphosphatase ($F_1$-ATPase)      223—224
$F_1$-ATPase ($F_1$-adenosine triphosphatase)      223—224
$P^1$,$P^2$-Bis (5'-pyridoxal)-diphosphate (Bis-PLP)      94
$P^1$,$P^2$-Bis (5'-pyridoxal)-polyphosphate      94
$S_N2$ mechanism      10 12
$\alpha$,$\alpha$-Bis(((p-chlorophenyl)sulfonyl)methyi)-4-nitroacetophenone      159
$\alpha$,$\alpha$-Bis(((p-chlorophenyl)sulfonyl)methyl) acetophenone      159
$\alpha$,$\alpha$-Bis(((p-chlorophenyl)sulfonyl)methyl)-m-nitroacetophenone      159
$\alpha$,$\alpha$-Bis(((p-chlorophenyl)sulfonyl)methyl)-p-chloroacetophenone      159
$\alpha$,$\alpha$-Bis(((p-tolysulfonyl)methyl)-4-nitroacetopenone      159
$\alpha$,$\alpha$-Bis(((p-tolysulfonyl)methyl)-m-nitroacetophe-none      159
$\alpha$,$\alpha$-Bis((p-tolysufonrl)methyl)p-aminoacetophenone      160
$\alpha$,$\alpha$’-Dibromo-p-xylene sulfonic acid      114
$\alpha$-Amylase      309
$\alpha$-Haloacetates      23 42
$\alpha$-Haloacetyls      30—32 34
$\alpha$-Hydroxyadipaldehyde      93
$\alpha$-Naphthol-2,4-disulfonyl chloride      90
$\alpha_2$-Macroglobulin      228 269 279
$\beta$-Galactosidase (GS)      248
$\beta$-Galactosidase (GS) in immunoconjugate characterization      260
$\beta$-Galactosidase (GS) in immunoconjugate preparation      209 210 255—257 259—260
$\beta$-Galactosidase (GS), stability and      215
$\beta$-Galactosidase (GS), thiolation and      20
$\beta$-Lactoglobulin      15
$\beta$-Lactoside      25
(4-Nitro-3-(1-chlorocarbonyloxyethyl)phenyl)methyl-3-(2-pyridyldithiopropionic acid) ester      279 283
(4-Nitro-3-(1-chlorocarbonyloxyethyl)phenyl)methyl-S-acetylthioic acid ester      278—279 283
(ABNA) Ethyl N-(5-azido-2-nitrobenzoyl)aminoacetimidate      170
1 -Diazoacetyl-1 -bromo-2-phenylethane      161
1,1-Bis(diazoacetyl)-2-phenylethane      53 124
1,2-Cyclohexanedione      42 43
1,2-Di(bromoacetyl)amino-3-phenylhydrazine      112
1,3-Bis(2-chloroethyl)-1-nitrosourea      115
1,3-Bis(trans-4-hydroxyhexyl)-1-nitrosourea      115
1,3-Dibromoacetone      111 121
1,4-Bis(bromomercuri)butane      105 106
1,4-ButadioldigIycidoxy ether      119
1,4-Butanediol diglycidyl ether (1,4-bis(2,3-epoxypropoxy)butane)      308
1,4-Dicanatobenzene      87
1,4-Phenylene diisothiocyanate      89
1,5-Diazidonaphthalene (DAN)      129
1,5-Dibromo-2,4-dinitrobenzene      86
1,5-Dichloro-2,4-dinitrobenzene      86
1,6-Diaminohexane      296
1,6-Hexamethylene diisocyanate (HMDI)      87
1,7-Diaminoheptane      296
1-(Aminooxy)-4-((3-nitro-2-pyridyl)dithio)but-2-ene      162 321
1-(Aminooxy)-4-((3-nitro-2-pyridyl)dithio)butane      161 321
1-Azido-5-naphthaleneisothiocyanate      172
1-Benzyl-3-(3-dimethylsminopropyl)carbodiimide (BDC)      196
1-Cyano-4-dimethylaminopyridinium tetrafluorborate      298
1-Cyclohexyl-3-(2-morpholinyl-(4)-ethyl)-carbodiim-ide metho-p-toluenesulfonate (CMC)      196
1-Cyclohexyl-3-(2-morphylinyl-(4)-ethyl) carbodiim-ide (CMC)      39 40 286
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)      196 260
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide in amination      23 25
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide in RNA-protein cross-linking      321
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide, carboxyl groups and      39 40
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide, contractile protein system and      226
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide, immunotoxins and      271—273 286
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide, membrane proteins and      240
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide, multi-subunit protein study with      223 224
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide, ribosomal protein arrangements and      225
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide methiodide      196
1-Ethyl-3-(4-azonia-4,4-dimethylpentyl)carbodiimide iodide (EAC)      196 199
1-Fluoro-2,4-dinitro-benzene      224
10,10'-Decamethylenebis(methanethiosulfonate)      107
2,2'-Bis(maleimidoethoxy)propane      110
2,2'-Dicarboxy-4,4'-azophenyldiisocyanate      88
2,2'-Dicarboxy-4,4'-azophenyldithioisocyanate      88
2,2'-Dicarboxy-4,4'-dibromoacetamidoazobenzene      113
2,2'-Dicarboxy-4,4'-diiodoacetamidoazobenzene      113
2,2'-Dicarboxy-6,6'-azophenyldiisocyanate      89
2,2'-Dithiobis-(succinimidyIpropionate) (DSP)      84
2,2-Bis(maleimidomethoxy)propane      111
2,3-Butanedione      42 43
2,4,5-Trichlorophenyl chlorocarbonate      303
2,4,5-Trichlorophenyl chloroformates      200
2,4,5-Trifluro-5-chloropyrimidine      308
2,4,6-Tri(ethyleneimino)-s-triazine      118
2,4,6-Trichloro-s-triazine      116
2,4-Dichloro-6(3'-methyl-4-aminoanilino)-s-triazine      116
2,4-Dichloro-6-(5'-sulfonic-acid-naphthaleneamino)-s-triazine      117
2,4-Dichloro-6-(sulfonic acid)-s-triazine      116
2,4-Dichloro-6-amino-s-triazine      116
2,4-Dichloro-6-methoxy-s-triazine      115 210
2,4-Dichloro-6-methoxytriazine      286
2,5-Hexanedione      95 101
2-(p-Nitrophenyl) allyltrimethylammonium iodine      159
2-(p-Nitrophenyl)allyl-4-nitro-3-carboxyphenylsulfide      158
2-Acetoxy-4-maleimidobenzoyl-chloride      157
2-Amino-4,6-dichloro-s-triazine      307
2-Bromoethylamine      23 25
2-Bromoethylmaleimide      158
2-Carboethylseleno-4-azido-2-nitrobenzoate      175
2-Carboxy-methylamino-4,6-dichloro-s-triazine      307
2-Carboxymethyloxy-4,6-dichloro-s-triazine      307
2-Chloro-4-maleimidobenzoyl-chloride      157
2-Cyanato-4-isothiocyanatotoluene      87
2-Diazo-3,3,3-trifluropropionyl chloride (DTPC)      172
2-Fluoro-1-methylpyridinium salt      305
2-Fluoro-N-methylpyridinium salt      306
2-Hydroxy-4-(N-maleimido)benzoylazide (HMB)      157
2-Hydroxy-5-nitrobenzyl bromide (HNBB)      42 44
2-Iminothiolane      95 103 251
2-Iminothiolane in ribosomal protein studies      224
2-Iminothiolane, immunotoxins and      268 269 273 275
2-Iminothiolane-modified anti-tissue plasminogen activator      130
2-lsocyanato-4-isothiocyanatotolulene      37
2-Mercaptoethanol      16 33 63 64 237
2-Mercaptoethylamine      16 248—249 251 254
2-Methoxy-2,4-dimethylglutaraldehyde      93
2-methoxy-4-nitrophenyl ether      184
2-Methyl-N’-benzenesulfonyl-$N^4$-bromoacetylquinone-diimide      162 183
2-Methylmaleic anhydride      66 278
2-Nitro-4-azidophenylsulfenyl chloride (NAPSCl)      174
2-Nitro-4-sulfonic acid-phenyl-6-maleimidocaproate (MAHNSA)      155 277
2-Nitro-5-thiobenzoate      7
2-Pyridyl disulfide      269 271
3'-Arylazido-$\beta$-alanine-$\delta$-azido-ATP      178
3'-Arylazido-$\beta$-alanine-8-azido ATP (di$\mathrm{N}_{3}$ ATP)      224
3'-o-(3-(N-Azido-(2-nitrophenyl)amino)-propionyl)-8-azidoadenosine-5'-triphosphate      182
3,3'-Dithiobis(sulfosuccinimidylpropionate) (DTSSP)      85 310
3,3'-Dithiobis-(succinimidylpropionate) (DSP)      84
3,4,5,6-Tetrahydroxysuberimidate (THS)      80
3,4-Isopropylidene-1,2:5,6-dianhydromannitol      119
3,6-Bis(acetoxymercurimethyl)dioxane      106
3,6-Bis(chloromercurimethyl)dioxane      106
3,6-Bis(mercurimethyl) dioxane      60 63 105 106 259
3,6-Bis(nitromercurimethyl) dioxane      106
3-((2-Nitro-4-azidophenyl)-2-aminoethyldithio)-N-succinimidylpropionate (NAP-AEDSP)      168
3-(2-Pyridyldithio)propionate      271
3-(3-Acetylthiopropionyl)thiazolidine-2-thione      20 24
3-(3-p-Methoxybenzylthiopropionyl)thioazolidine-2-thione      20 24
3-(4-Azido-2-nitrobenzoylseleno)propionic acid (ANBSP)      66 175
3-Amino-4-methoxyphenylvinyl sulfone      187 188
3-Aminopropyltriethoxysilane      296
3-Methoxy-2,4-dimethylglutaraldehyde      101
3-Methoxydiphenylmethane-4,4'-diisocyanate      88
3-Methylglutaraldehyde      93 101
3-Nitrotyrosine      25
3-Oxy-2,2-bis((((2-((3-carboxy-4-mtrophenyl)diothio)ethyl)-amino)carbonyl)hexanyl)-4,4-dimethyloxazolidine      106
3-Oxy-2,2-bis(6-((N-succinimidyloxy)carbonyl)hexanyl)-4,4-dimethyloxazolidine      82
3-Oxy-2,2-bis(8-((N-succinimidyloxy)carbonyl)octanyl)-4,4-dimethyloxazolidine      82
3-Oxy-2,2-bis-(6-(((3-((N-succinimidyloxy)carbonyl)propyl)amino)carbonyl)hexanyl)-4,4-dimethyloxazolidine      83
4'-Aminomethyl-4,5',8-trimethylpsoralen (AMT)      319
4'-Hydroxymethyl-4,5'-8-trimethylpsoralen (HMT)      319
4,4'-Diaminodiphenylamine      125
4,4'-Diaminodiphenyldisulfide      125
4,4'-Diaminodiphenylmethane      300
4,4'-Diazidobiphenyl (DABP)      129
4,4'-Dithiobisphenylazide (DTPA)      129 175 239
4,4'-Dithiodipyridine      33 251
4,4'-Dithiostilbene-2,2'-disulfonate      227
4,5',8-Trimethylpsoralen (TMP)      319
4-(2,2-Bis((p-tolysulfonyl)methyl) acetyl)benzoic acid      160
4-(Bromoaminoethyl)-3-nitrophenylazide (BANPA)      173
4-(Iodoacetylamino)-3,4,5,6-tetrahydrophthalic anhydride      278
4-Azidoiodobenzene      69 171
4-Azidophenylglyoxal (APG)      180
4-Azidophenylmaleimide (APM)      177
4-Azidophenylsulfenyl chloride      178
4-Chloroacetylphenylmaleimide      157
4-Fluoro-3-nitrophenylazide      17 183
4-Maleimidobenzophenone      226
4-Maleimidobenzoylchloride      157
4-Pyridyldisulfide      271
4-Succinimidyloxycarbonyl-$\alpha$-methyl-$\alpha$-(2-pyridyldithio)toluene (SMPT)      271—272
5'(p-Fluorosulfonylbenzoyl)-8-azidoadenosine (FSBAzA)      179 188
5,5'-Dithiobis-(2-nitrobenzoic acid) (DTNB)      see Ellman's reagent
5,5'-Pentamethylenebis(methanethiosulfonate)      107
5-((4,6-Dichloro-5-triazin-2-yl)amino)naphthalene-1-sulfonic acid      117
5-((4,6-Dichloro-s-triazin-2-yl)amino)fluorescein (5-DTAF)      117 122
5-(4,6-Dichloro-s-triazin-2-yl)-aminofluorescein diacetate      117
5-DTAF(5-((4,6-Dichloro-s-traizin-2-yl)amino)fluorescein)      117 122
5-Isothiocyanato-1-naphthalene azide      172
5-Thio-2-nitrobenzoate      181
6,6'-Hexamethylenebis(methanethiosulfonate)      107
8,8'-Octamethylenebis(methanethiosulfonate)      107
8-Azidoadenosine      188
8-Methoxypsoralen (8-MOP)      319
8-MOP (8-Methoxypsoralen)      319
ABC      see Avidin-biotin complex
Abrin      268 269 272 277 279
Acetic acid      14
Acetimidate      97
Acetophenones      63 see
Acetyls, cleavage and      66—67
Acid anhydrides      31 37 see
Acid halides      37 57 see
Acid-label cross-linkers      278 281
Acrolein      163
Acrylonitrile      302—303
Actin      226
Active-site-directed reagents      1
Acyl azides, amino group reactions and      91—92 100—101 147
Acyl azides, carbohydrate prosthetic groups and      27
Acyl azides, photoactivatable cross-linking and      128 183
Acyl azides, protein immobilization and      300
Acyl chlorides      147 184
Acyl halides      38
Acyl hydrazides      300
Acylating agents      see also Acylation; specific types
Acylating agents, amino groups and      37 87—92 99—101 147
Acylating agents, electrophilicity and      51
Acylating agents, tyrosine groups and      40
Acylation      10 11 see
Acylation in nucleophilic reactions      53—58
Adenine      188
Adenosine receptors      236
Adipaldehyde      93 101
Adipic acid dihydrazide      127 132—133
Adriamycin      267 279
Agarose      295—298 312
AGTC(W-(4-Azidobenzoyl-2-glycyl)-S-(2-thiopyridyl)cysteine)      175
Alanine      7
Aldehydes      35—37 101 296 299 see
Aliphatic side chains      7
Alkaline phosphatase (ALP)      248 254—255 260 320
Alkosilanes      296 see
Alkoxylamino groups      182
Alkyl azides      128 183
Alkyl halides      34 147 185
Alkylating agents      see also Alkylation; specific types
Alkylating agents, amino group reactions and      34—37
Alkylating agents, electrophilicity and      51
Alkylating agents, methionine and      42
Alkylating agents, sulfhydryl group reactions and      111—119 121—122 147
Alkylation      11 see
Alkylation described      10
Alkylation, disguised reagents and      188
Alkylation, immunotoxins and      286
Alkylation, in amino groups      35 51 53 60
Alkylation, in carbohydrate prosthetic groups      27
Alkylation, in zero-length cross-linking      203
Alkylation, nucleophilic reactions and      51—55
Alkylchloroformate      307
ALP      see Alkaline phosphatase
AMAS (N-Succinimidyl maleimidoacetate)      148
Amides      296 see
Amidines      37 see
Amination      23 25
Amino acid analysis      214
Amino acid side chains      60 188
Amino acid side chains, description of      7—8
Amino acid side chains, reactive      8—14
Amino group reagents      33—39
Amino group reagents, heterobifunctional      147—161 182
Amino group reagents, heterobifunctional, immunoconjugates and      251
Amino group reagents, heterobifunctional, protein immobilization and      310—312
Amino group reagents, homobifunctional      75—104
Amino group reagents, homobifunctional, acylating agents and      87—92 99—101
Amino group reagents, homobifunctional, aryl halides and      85—86 99
Amino group reagents, homobifunctional, bis-imidoesters and      75—81 98
Amino group reagents, homobifunctional, bis-N-succinimidyls and      81—85 98—99
Amino group reagents, homobifunctional, dialdehydes and      92—95 101
Amino group reagents, homobifunctional, diketones and      95 101
Amino group reagents, immunotoxins and      276—277
Amino group reagents, in immunoconjugate preparation      254 255 258 260
Amino groups      8 10 see
Amino groups, acylation and      53 57 58
Amino groups, alkylation and      35 51 53 60
Amino groups, cleavage and      66
Amino groups, conversion to carboxylic acids      16—17
Amino groups, conversion to sulfhydryl groups      17—20
Amino groups, photosensitive reagents anchored by      163—173 184—185
Amino groups, solid matrix activation of      296 299 300—302
Amino groups, thiol conversion to      23 25
Amino groups, tyrosine groups compared with      40
Aminooxypyridyldithio derivatives      182 see
Aminophenyl glycosides      27
Aminothiopyridine      182
Aminotyrosine      25 27
AMT (4'-Aminomethyl-4,5',8-trimethylpsoralen)      319
Analysis of cross-linked products      213—214
ANB-NOS (N-5-Azido-2-nitrobenzoyloxysuccin-imide)      164
ANBSP (3-(4-Azido-2-nitrobenzoylseleno)propionic acid)      66 175
Antibodies      130 258—259 see
Antigen-binding fragments (Fab)      248 254 256 258
Antigens      130 see
APB (p-Azidophenacyl bromide)      173 238
APG (4-Azidophenylglyoxal)      176
APM (4-Azidophenylmaleimide)      173
APTP (N-(4-Azidophenylthio)phthalimide)      58 61 174
Arginine group reagents      40—43 127 128
Arginine groups      7 8 11 13 see
Arrhenius equation      215 216
Artifacts of membrane cross-linking      234
Aryl azides      1 60—63 128 183 184
Aryl halides      31 35 36 54 85—86 99 147 184
Arylamine      312
Arylation      11 36
Arylazido-cystamine psoralens      320
Arylchloroformate      307
Arylsulfonyl fluorides      45
Asialofetuin      271
Asparaginase      228
Asparagine      8
Aspartic acid      7 8 10 11 13
Atrial natriuretic peptide (ANP) receptors      236
1 2 3 4 5
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