Wong S.S. — Chemistry of Protein Conjugation and Cross-Linking :: Электронная библиотека попечительского совета мехмата МГУ

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Wong S.S. — Chemistry of Protein Conjugation and Cross-Linking

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Название: Chemistry of Protein Conjugation and Cross-Linking

Автор: Wong S.S.

Аннотация:

University of Texas Health Science Center, Houston. Biochemistry - advanced research review.

Язык:

Рубрика: Химия/

Статус предметного указателя: Готов указатель с номерами страниц

ed2k: ed2k stats

Год издания: 1993

Количество страниц: 352

Добавлена в каталог: 21.11.2006

Операции: Положить на полку | Скопировать ссылку для форума | Скопировать ID

Предметный указатель

N,N’-Undecamethylene-bis(iodoacetamide)      111
N- $\gamma$ -Maleimidobutyryloxy      312
N-( $\beta$ -(4-Diazophenyl)ethyl)maleimide (DPEM)      257 259—260
N-( $\beta$ -Aminoethyi)-4-azido-2-nitroaniline      177
N-((p-Azido-p-iodophenylazo)benzoyl)-3-aminopropyl-N’-oxysuccinimide ester      171
N-(3-Fluoro-4,6-dinitrophenyl)cystamine      156
N-(3-Iodo-4-azidophenylpropionamide-S-(2-thiopyridyl)cysteine      175
N-(4(2,2-((p-Tolysulfonyl)methyl)acetyl)benzoyl)-4-iodoaniline      160
N-(4-(2,2-Bis(p-tolysulfonyl)methyl)-acetyl)benzoyl-1-(p-aminobenzyl)diethylenetriaminepenta-acetic acid      160
N-(4-(p-Azido-m-iodophenylazo)benzoyl)-3-aminopropyl N’-oxysulfosuccinimide ester      238
N-(4-(p-Azidophenylazo)-benzoyl)-3-aminohexyl-N-oxysuccinimide      66
N-(4-Azido-2-nitrophenyl- $\beta$ -aminoethyl)-N’-( $\beta$ -aminoethyl)tartramide      181
N-(4-Azido-3-nitrophenyl)-ethylenediamine      181
N-(4-Azidobenzoyl-2-glycyl)-S-(2-thiopyridyl)cysteine (AGTC)      175
N-(4-Azidobenzoylglycyl)-S-(2-thiopyridyl)-cysteine      49 50
N-(4-Azidocarbonyl-3-hydroxyphenyl)maleimide      157
N-(4-Azidophenylthio)phthalimide (APTP)      58 61 174
N-(4-Azodocarbonyl-3-hydroxyphenyl)maleimide      68 69
N-(4-p-Azidophenylazo)-benzoyl)-3-aminohexyl-N’-oxysuccinimide ester      167
N-(4-p-Azidophenylazo)benzoyl)-3-aminopropyl-N’-oxysuccinimide ester      171
N-(4-p-Azidophenylazo)benzoyl)-3-aminoundecyl-N’-oxysuccinimide ester      167
N-(5-Azido-2-nitrophenyl)-ethylenediamine      181
N-(Ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline (EEDQ)      197 202 258
N-(Isobutoxycarbonyl)-2-isobutoxy-1,2-dihydroquinoline (IIDQ)      197 202
N-(Maleimidomethyl)-2-(o-methoxy-p-nitrophenoxy)-carboxamidoethame      176
N-5-Azido-2-nitrobenzoyloxysuccinimide (ANB-NOS)      164
N-Acetylglucosamine      8 9 227
N-Acetylhomocysteine thiolactone      17 19
N-Acetylimidazole      40 41
N-Benzyl-N’3-dimethylaminopropylcarbodiimide      196
N-Bromosuccinimide (NBS)      42 44
N-Carbalkoxydihydroquino-lines      202
N-Carboxymethylation      42
N-Chloroacethylidotyramine      30 32
N-Chloroethylamine      277
N-Cyclohexyl-N’-( $\beta$ -N-methylmorpholine)ethyl)-carbodiimide p-toluene sulfonate      196
N-Ethyl-3-phenylisoxazolium-3'-sulfonate      see Woodward's reagent К
N-Ethylbenzisoxazolium      197
N-Ethylbenzisoxazolium tetrafluoroborate      195 200
N-Ethyleneiminoyl-1,6-diaminohexane      118
N-Ethylmaleimide (NEM)      30 32 252 253
N-Hexamethylenebisiodoacetamide      310
N-Hydroxybenzotriazole      300 301
N-Hydroxysuccinimide (NHS)      180 184
N-Hydroxysuccinimide chlorocarbonate      303
N-Hydroxysuccinimide in immunoconjugates      210 211
N-Hydroxysuccinimide, acylation and      53 56
N-Hydroxysuccinimide, amino groups and      37 38 98
N-Hydroxysuccinimide, contractile protein system and      226
N-Hydroxysuccinimide, immunotoxins and      277
N-Hydroxysuccinimide, membrane proteins and      235
N-Hydroxysuccinimide, nucleophilic reactions and      51
N-Hydroxysuccinimide, protein immobilization and      296 300 301
N-Hydroxysuccinimidyl iodoacetate      275
N-Hydroxysuccinimidyl-p-formylbenzoate      162
N-Maleimides      30—32 34 35 54
N-Maleimido derivatives      104
N-Succinimidyl 2,3-dibromopropionate      154
N-Succinimidyl 2-bromoacetate      320
N-Succinimidyl 3-(2-bromo-3-oxobutane-1-sulfonyl)propionate      153
N-Succinimidyl 3-(2-pyridyldithio)propionate      58 61 130
N-Succinimidyl 3-(2-pyridyldithio)propionate (SPDP)      20 21 148 181 251
N-Succinimidyl 3-(2-pyridyldithio)propionate, immunoconjugates and      210 252 254 255 258 259
N-Succinimidyl 3-(2-pyridyldithio)propionate, immunotoxins and      267—271 286
N-Succinimidyl 3-(2-pyridyldithio)propionate, inter-residue distance determinations and      223
N-Succinimidyl 3-(2-pyridyldithio)propionate, protein immobilization and      312
N-Succinimidyl 3-(2-pyridylthiol)propionate) (SPDP)      227
N-Succinimidyl 3-(4-bromo-3-oxobutane-1-sulfonyl)propionate      153
N-Succinimidyl 3-maleimido-4-(N,N-dimethyl)aminobenzoate      152
N-Succinimidyl 3-maleimido-4-methoxybenzoate      151
N-Succinimidyl 3-maleimidopropionate (BMPS)      148
N-Succinimidyl 4-((N,N-bis(2-chloroethyl))amino)phenylbutyrate      154
N-Succinimidyl 4-(N-idoacetyl)amino)benzoate (SIAB)      152
N-Succinimidyl 4-(N-maleimidomethy)cyclohexane-1-carboxylate (SMCC)      149 251 252 254 257—259 277 286
N-Succinimidyl 4-(p-maleimdophenyl)butyrate (SMPB) in antibody-protein coupling      259
N-Succinimidyl 4-(p-maleimidophenyl)butyrate (SMPB)      149 277
N-Succinimidyl 4-maleimido-3-methobenzoate      151
N-Succinimidyl 4-maleimidobutyrate      148
N-Succinimidyl 4-maleimidobutyrate (GMBS)      255 277
N-Succinimidyl 5-maleimido-2-methoxybenzoate      151
N-Succinimidyl 6-maleimidocaproate      149
N-Succinimidyl 6-maleimidylhexanoate (SMH)      149 251 252 254 257 258
N-Succinimidyl chlorambucil (4-(bis(2-chloroethyl)amino)-benzene butanoic acid N-hydroxysuccinimide ester      277—278
N-Succinimidyl m-maleimidobenzoate (SMB)      150 277
N-Succinimidyl maleimidoacetate (AMAS)      148
N-Succinimidyl N-(2-(4-azidosalicyloyl)oxy)ethyl)adipamate      170
N-Succinimidyl N-(2-(4-azidosalicyloyl)oxy)ethyl)suberamate      170
N-Succinimidyl N-(2-(4-azidosalicyloyl)oxy)ethyl)succinimate      170
N-Succinimidyl o-maleimidobenzoate      150
N-Succinimidyl p-maleimidobenzoate      151
N-Succinimidyl(4-iodoacetyl)aminobenzoate      275
N-Succinimidyl-(4-azido-2-nitrophenyl)- $\gamma$ -aminobutyrate (NHS-ANAB)      165
N-Succinimidyl-(4-azido-2-nitrophenyl)glycine      165
N-Succinimidyl-(4-azidophenyl)1,3'-dithiopropionate (SADP)      167
N-Succinimidyl-(4-iodacetyl)aminobenzoate      312
N-Succinimidyl-2-((4-azidophenyl)dithio)acetate (NHS-APDA)      166
N-Succinimidyl-3- {(2-nitro-4-azidophenyl)-2-aminoethyldithio)propionate (SNAP)      168
N-Succinimidyl-3-((4-azidophenyl)dithio)propionate (NHS-APDP)      167
N-Succinimidyl-4-azido-benzoylglycylglycinate (NHS-ABGG)      164
N-Succinimidyl-4-azido-benzoylglycyltyrosinate (NHS-ABGT)      165
N-Succinimidyl-4-azido-salicylate      163
N-Succinimidyl-4-azidobenzoate(HSAB;NHS-ABA)      163 236
N-Succinimidyl-4-azidobenzoylglycinate (NHS-ABG)      164
N-Succinimidyl-5-azido-2-nitrobenzoate (NHS-ANBA)      164
N-Succinimidyl-6-(4'-azido-2'-nitrophenylamino)hexanoate (SANPAH)      165 235—236 239
N-Succinimidyl-N-(N’(3-azido-5-nitrobenzoyl)tyrosyl)- $\beta$ -alanine      169
N-Succinimidyl-N-(N’(3-azidobenzoyl)-tyrosyl)- $\beta$ -alanine      169
N-Succinimidyl-N-(N’(4-azidobenzoyl)-tyrosyl)- $\beta$ -alanine      169
N-Succinimidyl-N’-(4 azidosalicyl)-6-aminocaproate (NHS-ASC)      164
N-Succinimidyl-N’-(4-azidonitrophenyl)dodecanoate      166
N-Succinimidylbromoacetate      153 321
N-Succinimidyliodoacetate      153
N-Sulfosuccinimidyl 4-(N-idoacetyl)amino)benzoate (Sulfo-SIAB)      153
N-Sulfosuccinimidyl 4-(p-maleimidophenyl)butyrate (Sulfo-SMPB)      149 277
N-Sulfosuccinimidyl m-maleimidobenzoate      150
N-Sulfosuccinimidyl-6-(4'-azido-2'-nitrophenylamino)hexanoate (Sulfo-SANPAH)      166
N-Sulfouccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate (Sulfo-SMCC)      149
N-Syccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate      147
NAP-AEDSP (3-((2-Nitro-4-azidophenyl)-2-aminoethyldithio)-N-succinimidylpropionate)      168
Naphthalene-1,5-disulfonyl chloride      90
NAPSCl (2-Nitro-4-azidophenylsulfenyl chloride)      174
Napththalene-1,5-dimaleimide (NDM)      109
NBS (N-Bromosuccinimide)      42
NDM (Napththalene-1,5-dimaleimide)      109
NDTFP(p-Nitrophenyl-2-diazo-3,3,3-trifluoropropionate)      173
Nearest neighbor analysis of membrane proteins      237—239
Nearest neighbor analysis of soluble proteins      223—227
NEM      see N-Ethylmaleimide
Neocarzinostatin      286
NHS      see N-Hydroxysuccinimide
NHS-ABA (N-Succinimidyl-4-azidobenzoate)      163 236
NHS-ABG (N-Succinimidyl-4-azidobenzoylglycinate)      164
NHS-ABGG(N-Succinimidyl-4-azido-benzoylglycylglycinate)      164
NHS-ABGT(N-Succinimidyl-4-azido-benzoylglycyltyrosinate)      165
NHS-ANAB (N-Succinimidyl-(4-azido-2-nitrophenyl)- $\gamma$ -aminobutyrate)      165
NHS-ANBA(N-Succinimidyl-5-azido-2-nitrobenzoate)      164
NHS-APDA (N-Succinimidyl-2-((4-azidophenyl)dithio)acetate)      166
NHS-APDP (N-Succinimidyl-3-((4-azidophenyl)dithio)propionate)      167
NHS-ASC (N-Succinimidyl-N’-(4 azidosalicyl)-6-aminocaproate)      164
Nitrenes      183 see
Nitrogen mustards      121 123 319
Nitrosoureas      115 122 319 see
Nitrostyrene      300
Nitrous acid      25 300
Non-specific reactions      60—63
Noncovalent homobifunctional cross-linkers      128—132
Nucleic acids      1 319—321 see
Nucleophilic reactions      10—12 28 50—58
Nucleophilic reactions, acylation in      53—58
Nucleophilic reactions, alkylation in      51—55

Nucleophilic reactions, in amine/sulfydryl conversion      17
O-Acylisoureas      123 195 199
O-Acyltyrosine      39
o-Dianisidine      125
o-Phthalaldehyde      93 101
O-Sulfonyltyrosine      39
Oligosaccharides      8 132 see
One-step procedures      209 253 254
Ortho esters      66—67
Ouabain      279
Ouchterlony techniques      214
p-Aminophenyl- $\beta$ -galactoside      25
p-Azidophenacyl bromide (APB)      173 238
p-Azidophenylglyoxal      185
p-Azidophenylisothiocyanate      176
p-Benzoquinone      103 254 309
p-Bis(ureido)-(1-iodoacetamido-2-ethylamino)oligoproplylazobenzene      114
p-Bis-(ureido)azido oligoprolylazobenze      92
p-Bis-(ureido)oligoprolylazobenzene      100—101
p-Chloromercuribenzoate (PCMB)      32 33
p-Hydroxymercuribenzoate (PHMB)      32 33
p-Maleimidobenzoyl chloride      321
p-Nitrochloromethylbenzene      300
p-Nitrophenol      53 300
p-Nitrophenyl      38 56 147 181 184
p-Nitrophenyl 3-(2-bromo-3-oxobutane-1-sulfonyl)propionate      154
p-Nitrophenyl 3-(4-bromo-3-oxobutane-1-sulfonyl)propionate      154
p-Nitrophenyl 3-diazopyruvate      173 227
p-Nitrophenyl 6-maleimidocaproate      155
p-Nitrophenyl chlorocarbonate      303
p-Nitrophenyl diazoacetate      161
p-Nitrophenyl diazopyruvate      161
p-Nitrophenyl-2-diazo-3,3,3-trifIuoropropionate (NDTFP)      173
p-Nitrophenylbromoacetate      155
p-Nitrophenylchloroformate      96 104 197 200 201
p-Nitrophenyldiazoacetate      173
p-Nitrophenylsulfenyl chloride      44
p-Phenylene-diisothiocyanate      89
p-Phenylenebis(maIeimide)      224
p-Phenylenediamine      124
p-Phenylenediglyoxal      127
p-Toluene sulfonyl chloride      306
p-Toluenesulfonyllysinechloromethyl ketone (TLCK)      42 44
p-Toluenesulfonylphenylalaninechloromethyl ketone (TPCK)      42 44
PAP (Pokeweed antiviral protein)      268 269 277—279
Papain      248 309
PCMB (p-Chloromercuribenzoate)      32 33
PDD (Pyridyl-2,2'-dithiobenzyldiazoacetate)      161 175
Peptides      1 see
Periodates      182
Periodates in immunoconjugate preparation      253—255
Periodates, carbohydrate activation by      27 37
Periodates, cleavage and      64 98 212
Phenanthroline      239
Phenol-2,4-disulfonyl chloride      57 90
Phenolate group reagents in immunoconjugate preparation      257
Phenolate group reagents, homobifunctional      123—126 128
Phenolate groups      8 10 35 53 see
Phenylalanine      7
Phenylamine      25 58
Phenyldiglyoxal      319
Phenylglyoxal      40 43 60
Phenylisothiocyanate      27 28
Phenylmethylsulfonylfluoride      45
Phloroglucinol      310
PHMB (p-Hydroxymercuribenzoate)      32 33
Phosgene      302
Phospholamban      238
Phosphoryl azides      128
Photoactivatable reagents      212
Photoactivatable reagents, heterobifunctional      163—179 183—188
Photoactivatable reagents, heterobifunctional, amino group anchored      163—173 184—185
Photoactivatable reagents, heterobifunctional, carboxamide group anchored      177 185
Photoactivatable reagents, heterobifunctional, carboxyl group anchored      177 185
Photoactivatable reagents, heterobifunctional, guanidinyl group anchored      176 185
Photoactivatable reagents, heterobifunctional, membrane proteins and      233 235—236
Photoactivatable reagents, heterobifunctional, photoaffinity reagents and      178—179 188
Photoactivatable reagents, heterobifunctional, sulfhydryl group anchored      173—176 185
Photoactivatable reagents, homobifunctional      128
Photoaffinity reagents      1 60—63 147 178—179 188 224
Photocleavable cross-linkers      278—279
Phthalaldehyde      101
Phycobiliproteins      259
Phytohemagglutinin      235
PLP      see Pyridoxal phosphate
Pokeweed antiviral protein (PAP)      268 269 277—279
Poly(4,4'-diaminodiphenylamine-3,3'-dicarboxylic acid)      126
Poly(p-amino-D,L-pheny lalanyl-L-leucine)      126
Poly-p-aminostyrene      300
Polyacrylamide      295 297
Polyacrylonitrile      302
Polyglutamic acid      286 287
Polyhydroxylic matrices      306
Polymethylenebis(methanethiosulfonate)      107 120
Polysaccharide spacers      279
Polysaccharides      295 see
Polyvinyl      297
Polyvinylalcohol      297
Potassium nitrosyldisulfonate      126 128 202
Procedures for cross-linking      209—213
Proline      7
Prosthetic groups of protein      8
Protein composition      7—8
Protein functional groups      see Functional protein groups
Protein immobilization      296—312
Protein organization      224—225
Protein-antibody coupling      258—259
Protein-enzyme coupling      259—260
Protein-matrix conjugation      295—313 see
Protein-protein interactions      227 239
Protonation      12—14
Pseudomonas exotoxin (PE)      268
Purothionin      286
Pyridine      23
Pyridine borane      27
Pyridoxal phosphate (PLP)      35 240
Pyridyl-2,2'-dithiobenzyldiazoacetate (PDD)      161 175
Pyridyldisulfide      252 271—272
Pyrrole- $\alpha$ -acyl azide      210
Quaternary structures      223—224
Quinones      309 see
Radial diffusion techniques      214
Radioactive isotopes      68 69
Radioimmunoassay (RIA)      245
Radioimmunoconjugates      267
Radioisotope labeling      214
ras oncogene      239
Reaction complications      214—217
Reactive amino acid side chains      8—14
Reagents      49—70 see
Reagents cleavage      63—67
Reagents, electrophilic reactions and      58
Reagents, group-directed reactions of      58—60 see
Reagents, labeled      67—68
Reagents, non-specific reactions in      60—63
Reagents, nucleophilic reactions of      50—58
Reporter groups      67
Rhodosaminylanthracyclinone anthracyclines      321
RIA      see Radioimmunoassay
Ribonuclease      15
Ribosomal protein arrangements      224—225
Ribosome-inactivating protein (RIP)      268 277
Ricin      268 269 271 272 273 274 275
Ricin in multi-step procedures      286
Ricin, carbohydrate coupling and      279
Ricin, chlorambucil conjugation and      277
Ricin, thioether linkage and      275 276
RIP (Ribosome-inactivating protein)      268 277
RNA cross-linking      225 319 321
S-4-Succinimidyl oxycarbonyl- $\alpha$ -methyl benzyl thiosulfate (SMBT)      274

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