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| Wong S.S. — Chemistry of Protein Conjugation and Cross-Linking |
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| Предметный указатель |
Ethyl N-(carbamoylcyanomethyl) acetimidate 187 188
Ethyl-(4-azidophenyl)-1,4-dithiobutyrimidate (EADB) 171 238
Ethylchloroformate 96 104 105 195 197 200 201 204 303 307
Ethylenediamine 27 312
Ethyleneglycol bis(succinimidylsuccinate) (EGS) 84 237 310
Ethylenimines 23 25
FAB see Antigen-binding fragments
FAPOB (Methyl-4-(6-formyl-3-azidophenoxy)butyrimi-date) 163 171
Ferritin-antibody conjugates 259
Ferritin-avidin conjugates 203
Fetuin 271
Ficoll 27 28
Fluorescent probes 67 68 245
Fluoroacetate 23
Fluoropyrimidines 307 308 see
Fluorosulfonyl 188
FNA(4-Fluoro-3-nitrophenylazide) 171 183
FNPA (4-Fluoro-3-nitrophenylazide) 171 183
Formaldehyde 1 95 101 103 321
FSBAzA (5'(p-Fluorosulfonylbenzoyl)-8-azidoadenosine) 179 188
Fucose 9
Functional protein groups 8—27
Functional protein groups, amino acids in 8—14
Functional protein groups, chemically introduced 14—27
Furocoumarins 319
G6PDH (Glucose-6-phosphate dehydrogenase) 248 257
Galactose 8 9
Gel-filtration chromatography 1 213
Gelonin 268 269 271 277 278 281
Glucoamylase 309
Glucose oxidase (GO) 248 258 260 309
Glucose-6-phosphate dehydrogenase (G6PDH) 248 257
Glutamic acid 7 8 10 11 13
Glutamine 8 185
Glutaraldehyde 35 93 101 102 210 267
Glutaraldehyde in ALP immunoconjugates 254—255
Glutaraldehyde in GO immunoconjugates 258
Glutaraldehyde in GS immunoconjugates 257
Glutaraldehyde in HRP immunoconjugates 252—253
Glutaraldehyde in protein-antibody coupling 258
Glutaraldehyde in protein-enzyme coupling 259
Glutaraldehyde, DNA-protein conjugates and 320
Glutaraldehyde, protein immobilization and 296 300 306—307
Glutaric anhydride 27
Glyceraldehyde-3-phosphate dehydrogenase 228
Glycerol polyglycidyl ether 122
Glycine methyltransferase 7
Glycoconjugates 130 132
Glycogen phosphorylase 227—228
Glycol bond cleavage 212
Glycoproteins 8 9 66 182 313 see
Glycosidic linkages 8
Glycyltyrosine 312
Glyoxal 40 43 92 101
GMBS see N-Succinimidyl 4-maleimidobutyrate
Go see Glucose oxidase
Gonadotropin receptors 237
Group directed reagents 27—45 see
Group directed reagents, amino group specific see Amino group reagents
Group directed reagents, arginine group specific 40—43
Group directed reagents, carboxyl group specific see Carboxy group reagents
Group directed reagents, histidine-specific 42 44
Group directed reagents, mercurial group specific see Mercurial group reagents
Group directed reagents, methionine-specific 42
Group directed reagents, reactions in 58—60
Group directed reagents, serine-specific 44—45
Group directed reagents, sulfhydryl group specific see Sulfhydryl group reagents
Group directed reagents, tryptophan-specific 42—44
Group directed reagents, tyrosine group specific 40 41
GS see  -Galactosidase
Guanidinyl groups 8 10 128 176 185
Haloacetamides 34
Haloacetyls 54
Haloketone 147
Henderson — Hesselbalch equation 12
Herpes simplex virus 237
Heterobifunctional reagents 1 147—188
Heterobifunctional reagents, amino groups of see under Amino group reagents
Heterobifunctional reagents, carbonyl groups of 161—162 182
Heterobifunctional reagents, carboxyl groups of 161 182
Heterobifunctional reagents, disguised 188
Heterobifunctional reagents, immunoconjugates and 209 210 251
Heterobifunctional reagents, photoactivatable see Photoactivatable heterobifunctional cross-linkers; Photoactivatable reagents
Heterobifunctional reagents, protein immobilization and 310—312
Heterobifunctional reagents, sulfhydryl groups of see under Sulfhydryl group reagents
Heterobifunctional reagents, zero-length cross-linkers compared with 195
Heterocyclic halides 307—308
Hexahydrobiphenyl-4,4'-diisocyanate 88
Hexamethylenediisocyanate 310
Hexokinase 239
High pressure liquid chromatography (HPLC) 213
Histidine 7 8 11 13 17 40 58
Histidine reagents 42 44
HMB (2-Hydroxy-4-(N—maleimido)benzoylazide) 157
HMDI (1,6-Hexamethylene diisocyanate) 87
HMT(4'-Hydroxymethyl-4,5'-8-trimethylpsoralen) 319
HNBB (2-Hydroxy-5-nitrobenzyl bromide) 42
Homobifunctional reagents 1 75—133 185
Homobifunctional reagents in immunoconjugate preparation 209 210
Homobifunctional reagents in immunotoxin preparation 267
Homobifunctional reagents in protein immobilization 306—310
Homobifunctional reagents, amino group see under Amino group reagents
Homobifunctional reagents, argininine group 127 128
Homobifunctional reagents, carboxyl group see under Carboxyl group reagents
Homobifunctional reagents, heterobifunctional reagents compared with 147
Homobifunctional reagents, noncovalent 128—132
Homobifunctional reagents, phenolate group see under Phenolate group reagents
Homobifunctional reagents, photoactivatable 128
Homobifunctional reagents, sulfhydryl group see under Sulfhydryl group reagents
Homobifunctional reagents, zero-length cross-linkers and 195 202
Horseradish peroxidase (HRP) conjugates 203 245—246 248
Horseradish peroxidase (HRP) conjugates as zero-length cross-linkers 204
Horseradish peroxidase (HRP) conjugates, characterization of 260—261
Horseradish peroxidase (HRP) conjugates, nucleic acids and 320
Horseradish peroxidase (HRP) conjugates, preparation of 210 251—254
Horseradish peroxidase (HRP) conjugates, stability and 216—217
HPLC (High pressure liquid chromatography) 213
HRP see Horseradish peroxidase
HSAB (N-Succinimidyl-4-azidobenzoate) 163 236
Hydrazine 296
Hydrophilicity 7 8 69 70 98
Hydrophobicity 7 8 69 70 233
Hydroxyethyl methacrylate 306
Hydroxyl groups 8 12 14 16 147
Hydroxyl groups, conversion to sulfhydryl groups 23—26
Hydroxyl groups, epoxides and 122
Hydroxyl groups, s-triazines and 122
Hydroxyl groups, solid matrix activation of 296—300
Hydroxylamine 17 20
Hydroxylamine in cleavage 213
Hydroxylamine, acylation and 37
Hydroxylamine, tyrosine groups and 40
IIDQ (N-(Isobutoxycarbonyl)-2-isobutoxy-1,2-dihydroquinoline) 197 202
Imidates 211 see
Imidazole 35
Imidazolyl group reagents, homobifunctional 123—126 128
Imidazolyl groups 8 10 see
Imidazolyl groups, acylation and 37 53
Imidazolyl groups, alkylation and 53
Imidazolyl groups, carboxylation and 23
Imidazolyl groups, microenvironment effect on 14
Imidazolyl groups, pH effect on 12
Imidoesters 31 97 184 211 see
Imidoesters, acylation and 53 56 57
Imidoesters, alkylation and 51
Imidoesters, amino groups and 37 38
Iminothiolane 19 20
Immunoassays 245—261 see
Immunoconjugates 2 245—261 see
Immunoconjugates, characterization of methods in 260—261
| Immunoconjugates, preparation of 209—211 250—258
Immunoconjugates, stability of 215—217
Immunodiffusion 214
Immunoelectrophoresis 213—214
Immunoenzymometric assays 245 246
Immunogenicity 215
Immunoglobulins 130 248—251
Immunomodulators 267
Immunotoxins 267—287
Immunotoxins, ABC in preparation of 286
Immunotoxins, acid-label cross-linkers and 278 281
Immunotoxins, carbohydrate coupling and 279
Immunotoxins, chlorambucil conjugation and 277—278
Immunotoxins, disulfide bond conjugation in 268—274
Immunotoxins, photocleavable cross-linkers and 278—279
Immunotoxins, selection of 267—268
Immunotoxins, stability of 215—217
Immunotoxins, thioether linkage conjugation of 275—277
In-vitro mutagenesis 1
Indolyl groups 8 10
Inter-residue distance determinations 221—223
Interferon- 269
Interferon- 236
Interleukin-2 278 281
Intermolecular cross-linking 3 214 221
Intramolecular cross-linking 3 214 221
Invertase 309
Iodine monochloride 68
Iodoacetate 23 30 32
Iodoacetyl compounds 275 see
Iodoacetylcystamine 274
Iodogen 68
Ion-exchange chromatography 1
Isobutyl chloroformate 27 200
Isocyanates 31 37 38 see
Isocyanates, acylation and 56 57
Isocyanates, protein immobilization and 302 303
Isoleucine 7
Isopsoralen 319
Isothiocyanates 31 37 38 184 see
Isothiocyanates, acylation and 56—58
Isothiocyanates, protein immobilization and 302 303
Isoxazolium derivatives 199—200
Ketals 66—67
Ketones 35—37 101
L-Tyrosine-bis(p-azobenzenearsenate) (Bis-RAT) 130 132
Labeled reagents 67—68
Lactate dehydrogenase 228
Lactoperoxidase 68
Lactose synthase 227
Leaving groups 51 56 57
Lectins 128 130—132 247
Leucine 7
Lewis base 10
Loman's reagent 84 165
Lysine 7 8 10 11 185
Lysine, conversion of 16
Lysine, diazonium and 40
Lysine, diketones and 101
Lysine, pH effect on 13
Lysozyme 15
m-Maleimidobenzoyl-N-hydroxysuccinimide ester (MBS) 150 209 255 258 267 276 286
m-Maleimidobenzoyl-sulfosuccinimide ester (Sulfo-MBS) 150 277
MA (Methyl acetimidate) 75 76
MABI (Methyl-4-azidobenzimidate) 170 239
MADB (Methyl-4-((4-azidophenyl)dithio)-butyrimidate) 171
MADP(Methyl-(3-(4-azidophenyl)dithio)-propionimidate) 171
MAHNSA see 2-Nitro-4-sulfonic acid-phenyl)-6-maleimidocaproate
Maleic anhydrides 17
Maleimides 185
Maleimidoethoxy(p-(N-succinimidylpropionato)-phenoxy)ethane 152
Maleimidomethyl-3-maleimidopropionate (MMP) 66 110
Maleylamide linkage, cleavage of 66
Malondialdehyde (MDA) 92 101
Mannose-N-acetylglucosamine 8
MAPA (Methyl-3-(4-azidophenyl)acetimidate) 170
Masked reagents 188
MBS see m-Maleimidobenzoyl-N-hydroxysuccinimide ester
MDA (Malondialdehyde) 92 101
Mechanism-based irreversible modifying agents 1
Melanotropin 279
Membrane proteins 221 233—240
Mercaptans 185 see
Mercaptomethyldimethylethyoxysilane 312
Mercaptopropyltrimethyloxysilane 312
Mercurial group reagents 60 104—106 120
Mercurial groups 31—33 63 see
Mercuric ion 106
Meromyosin 226
Merozoites 238
Methanol 51 56
Methionine 7 8 10 11
Methionine reagents 42
Methotrexate 267 271 286
Methoxy-p-nitrobenzene 184
Methyl 3-(4-pyridyldithio)mercaptopropionimidate 271
Methyl 3-(4-pyridyldithio)propionimidate 19 156
Methyl 3-mercaptopropionimidate 19 20 268 274
Methyl 4-(6-formyl-3-azidophenoxy)butyrimi-date (FAPOB) 163 171
Methyl 4-mercaptobutyrimide 19 20
Methyl 4-thiobutyrimidate 20
Methyl acetimidate (MA) 75 76
Methyl mercaptobutyrimidate 321
Methyl-(3-(4-azidophenyl)dithio-propionimidate (MADP) 171
Methyl-2-pyridyl disulfide 33
Methyl-3-(4-azidophenyl)acetimidate (MAPA) 170
Methyl-3-nitro-2-pyridyl disulfide 33
Methyl-4-((4-azidophenyl)dithio)-butyrimidate (MADB) 171
Methyl-4-azidobenzimidate (MABI) 170 239
Methyl-4-mercaptobutyrimidate 223
Methyl-5-bromovalerimidate 273
Microenvironment 7 14—16 30
Mitomycin C 279
MMP (Maleimidomethyl-3-maleimidopropionate) 66 110
Modeccin 268
Molecular distances 221—222
Monohalogenacetyl halide 310
Mucobromic acid 96 104 105
Mucochloric acid 96 104
Multi-step procedures 210—211 286
Multi-subunit proteins 223—224
Mutagenesis 1
Mutogenic fibrinogen receptor (MFR) 237
Myoglobin 15
myosin 226
N(-(’-Aminoethyldithioethyl))-4-azido-2-nitroaniline 177
N,N’-(1,2-Phenylene)bismaleimide 109
N,N’-(1,3-Phenylene)bismaleimide 109
N,N’-(1,4-Phenylene)bismaleimide 109
N,N’-(4-Azido-2-nitrophenyl)-cystamine dioxide 58 61
N,N’-Bis(-iodoacetyl)-2,2'-dithiobisethylamine (DIDBE) 113
N,N’-Bis(-iodoacetyl)ethylenediamine 111
N,N’-Bis(3-succinimidyloxy-carbonylpropyl) tartaramide (BSOPT) 85
N,N’-Bis(idoacetyl)polymethylenediamine 111
N,N’-Bis(iodoacetyl)-undecamethylenediamine 111
N,N’-Bis(iodoacetyl)hexamethylenediamine 111
N,N’-Bis(P-aminoethyl)tartramide 127 133
N,N’-Bis(p-azido-o-nitrophenyl)-1,3-diamino-2-propanol 129
N,N’-Bis(P-bromoethyl)benzylamine 115
N,N’-Bis2-carboximidoethyl)tartarimide dimethyl ester (CETD) 80
N,N’-Bis2-carboximidomethyl)tartarimide dimethyl ester (CMTD) 80
N,N’-Di(bromoacetyl)phenylhydrazine 112
N,N’-Dodecamethylenebismaleimide 108
N,N’-Ethylene-bis(iodoacetamide) 111
N,N’-Hexamethylenebisiodoacetamide 111
N,N’-Hexamethylenebismaleimide 108
N,N’-Methylenebismaleimide 107
N,N’-o-Phenylenedimaleimide 256
N,N’-Oxydimethylenedimaleimide 256
N,N’-Trimethylenebismaleimide 108
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