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Àâòîðèçàöèÿ |
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Ïîèñê ïî óêàçàòåëÿì |
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Twyman R.M. — Advanced Molecular Biology: A Concise Reference |
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Ïðåäìåòíûé óêàçàòåëü |
Parvovirus 474
Passive transposition 169 170f
Pattern formation 65 72—75
PCR 279—285
PCR mutagenesis 282
PCR products, cloning 283
Pedigree analysis 15—16bx
Penetrance 8
Peptide nucleic acid (PNA) 366
Peptidyl-tRNA 318
PEST domain 310
Phage display 305 346
Phagemids 327—329
Phasmids 327
Phenocopy 17
Phenotype 2
Phenotypic variance 17—18bx
Philadelphia chromosome 258
Phosphodiester bond 225
Phosphoinositide 3-kinase 347f
Photoreactivation 190
Physical mapping, low resolution 151—152t
Physical maps 146
Pilus 118
Plaque lift 358-359
Plasmid cloning vectors 327—329
Plasmid maintenance 272 275—276t
Plasmid partition 22 272
Plasmid phenotypes 273
Plasmid replication 276—277
Plasmid rescue 176 344
Plasmids 271—278
Plasmids, classification 271—273
Plasmids, conjugarive and nonconjugative 272 273 277—278bx
Plasmids, copy number 273—275
Plectonemic joint 232
Pleiotropy 2 103
Ploidy 45 133—134
Point mutation 202
Polar mutation 110 319
Poly(A) tail 413
Polyadenylate polymerase 408 413
Polyadenylation 413
Polycistronic mRNA 104 266—268
Polygenic theory 12
Polymerase chain reaction (see “PCR”)
Polymorphism 201 212
Polypeptides 287—289
Polypeptides, polarity 287—289
Polypeptides, chemical bonds in 287—289f
Polyploidy 46—47
Polyproteins 105
Polyteny, polytene chromosomes 47 58—59
Poly{A)+ RNA 334 414
Position effect variegation 42
Position effects 45 207
Positional cloning 335—336
Positional information 65 72
Positive-negative dual selection 351—352f
Post-replicative mismatch repair 94 194—195
Potency 72
POU domain 238—239 246
Precise excision, of transposons 172
Preformation 65
Prime plasmid 272
Primer extension 38—39t 340f
Primers for PCR 279
Primers, arbitrary 281
Priming strategies 405t
Primosome 397
Prion hypothesis 479—481
Programmed misreading 319
Programmed mutation 212 218—220bx
Promiscuous DNA 268
Promoter 443
Promoter clearance 443
Promoter trap 345
Promoter, structure of bacterial 446f
Promoter, structure of eukaryote 448—449 446f
Proofreading in replication 183—185
Proofreading in translation 129
Prophage 468
Prosthetic group 292
Protein degradation 310
Protein families 297—304
Protein families, chimeric 287 300—303
Protein families, conventional 297—300
Protein families, selective expansion 303—304
Protein folding 293-294
Protein modification 295—297t
Protein polymorphisms 150 211
Protein secretion 309
Protein sequencing 307
Protein synthesis 313—322
Protein synthesis, elongation cycle 317—318
Protein synthesis, initiation 130 316—317f
Protein synthesis, overview of mechanism 315—316
Protein synthesis, regulation 318—320
Protein synthesis, termination 318f
Protein targeting 309—310bx
Protein targeting to membranes 310
Protein targeting to organelles 310
Protein targeting, signal sequences 308—309
Protein truncation test 337
Protein-nucleic acid interaction 232 235—252 343
Protein-nucleic acid interaction, characterization of 249—252
Protein-nucleic acid interaction, direct binding 244
Protein-nucleic acid interaction, modulation of tertiary structure 245
Protein-nucleic acid interaction, ordered water molecules 245
Protein-nucleic acid interaction, protein dimerization 244
Protein-nucleic acid interaction, sequence specificity 246—249
Proteins 287—310
Proteins, primary structure 287—289
Proteins, quaternary structure 292
Proteins, secondary structure 289—290
Proteins, structural determination 307—308bx
Proteins, tertiary structure 290—295
Proteome 288 304
Proto-oncogenes 254—255
Prototroph 215
Provirus 468
Pseudoautosomal inheritance 4 15—16
Pseudoautosomal region 4 57
Pseudogene 107 139
Pseudogene, nonprocessed 140
Pseudogene, processed 140 166 182
Pseudoknot 232
Puffer fish, use in genome analysis 155
Pulsed field gel electrophoresis 355—356
Quantitative inheritance 11—15
Quantitative PCR 284
Quantitative trait loci 150—151
Quenching 455
R-banding 59
Race 284
Radiation hybrid mapping 146—147f
Raf, raf gene 254—258 432
RAG proteins 381
Ramachandran plot 288—289f
Random genetic drift 212—213
Random mutagenesis 348
RAPD markers 150 281
Ras, ras gene 254—258 432
RB1 gene 29 33 258—260
Reading frame 127—128f
Readout of DNA sequences by proteins 246—249
Readthrough (protein synthesis) 319
Readthrough mutation 204
Reassociation kinetics 135 157—159bx
RecA in recombination 384bx
| RecA in SOS mutagenesis 197—198
RecBCD nuclease 372
RecBCD pathway 372
Receptor serine/threonine kinases 430—411
Receptor tyrosine kinases 427—428f
Recessive 1—2 209
Reciprocal cross 4
Recombinant DNA 323 370
Recombinant selection 330—331
Recombination as a repair mechanism 197 371
Recombination fraction 148
Recombination frequency 147
Recombination signal sequence 380
Recombination, different classes 369—387 370t
Recombination, hotspots and coldspots 161
Recombination, molecular basis 384
Redundancy, structural and functional 140
Refolding model of prion replica Hon 480f
Regional specification 65
Rel family 242—243 256
Relaxed control, relaxed plasmid 272 277
Release factor 318
Reovirus 475
Rep protein bacterial helicase 398
Rep protein in plasmid replication 276—267
Repair deficiency syndromes 189t
Repairosome 193
Repetitive DNA 133 136 137 141f
Repetitive DNA mutations involving 207-8
Repetitive DNA, transposable elements as 141—142
Replication 389—409
Replication banding 59
Replication fidelity of 183—185
Replication fork 390
Replication initiation 400—404
Replication intermediates 409
Replication linear genomes 405—406t
Replication modes of 401t
Replication regulation 29—30 406—407
Replication slipping 184 208f
Replication termination 404—406
Replication time zone 406—407
Replication-deficient mutants 392—393t
Replicative form 392 473
Replicative intermediates 392
Repliconation 118—119f
Replisome 392—400
Replisome prokaryote and eukaryote compared 401t
Reporter genes 342—343t
Reporter vectors 343
Representational difference analysis 283
Resolution, of cointegrate 169 386
Response elements 458
Restriction enzymes/endonucleases 93 323—326 353—355bx
Restriction fragment length polymorphism 150 211
Restriction map 153—154 336—338f
Restriction point 25
Retinoblastoma 258—259
Retinoblastoma protein 29 33 258—260
Retroelements 180—182
Retrons 182
Retroposition 169—170 171f
Retroposons 182
Retroregulation 423 484
Retrotransposition 169—170 171f
Retrotransposons 180—181
Retroviruses generation of transgenic animals 364
Retroviruses life cycle 169—170 171f 468 475 476f
Retroviruses mechanism of integration 169—170 171f
Rev protein 421 485
Reverse genetics 213
Reverse hybridization 358
Reverse transcriptase 407 169—170 283—284 333 475—476
Reverse transcriptase PCR 283—284 339
reversion 209
Reversion -dependent termination 460
Ribbon-helix-helix motif 242
Ribosomal proteins 314
Ribosomal RNA (rRNA) 224 314
Ribosomal RNA (rRNA) genes 58 136 139 300
Ribosomal RNA (rRNA) processing 412
Ribosome binding site 313
Ribosomes 314
Ribozymes 224 232
Ring chromosome 51
RNA 223—224
RNA editing 266—268 421 422t
RNA export 421
RNA polymerase II, C-terminal domain 449
RNA polymerases 407 443
RNA polymerases eukaryotic 447t
RNA processing 411—424 411t
RNA splicing 414-421
RNA splicing nuclear introns 414—416
RNA stability, regulation of 422—424
RNA structure 228f 230—231
RNA structure recognition by proteins 236—237
RNA targeting 421
RNA tumor viruses 254 256 258
RNA viruses 470 474—475
RNA viruses protein synthesis in eukaryotes 477t
RNA-binding motifs in proteins 237t 243—244
RNP domain 243
Robertsonian/whole arm 52—53
Rot analysis 157—159bx
RT-PCR 283—284 339
Runaway replication 274—275
S phase 23
SAP kinase 433—434
Satellite association 58
Satellite DNA 137 142
Satellite nucleic acids 479
Satellite region 58
Satellite viruses 479
Scanning hypothesis 317 319
Scanning mutagenesis 347
SCID 381
Second messengers 434—440
Second site mutations 220—22lbx
Segment polarity genes 73 83
Segregation, equal 3
Selection in genetic screens 214
Selection in molecular cloning 330—331
Selection natural and artificial 17—18bx 212—213
Selection pressure 213
Selenocysteine 130
Selenocysteine insertion sequence 130
Selenoproteins 130
Self-splicing introns 266—268 416—418
Selfish DNA 137
Sense codon 127
Sense strand 444
Sequence homogenization 287 299 300
Sequence tagged sites 153
Serial analysis of gene expression (SAGE) 304
Sex determination 75—76t
Sex-chromosomes 57
Sex-linkage, sex-linked inheritance 4—5f 15—16bx
Sexduction 119 125bx
SH2 domain 432 435 441
Shapiro intermediate 168f
Shine — Dalgamo sequence 316
Short tandem repeat polymorphism 150
Shotgun sequencing 163
Shuttle vector 327 341—342 360—361
Sib pair analysis 149
Sickle cell anemia/trait 212—213 216—217bx
Signal joint 380
Signal transduction 425—442
Signal transduction immune system 429—430
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