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| Ïîèñê ïî óêàçàòåëÿì |
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| Twyman R.M. — Advanced Molecular Biology: A Concise Reference |
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| Ïðåäìåòíûé óêàçàòåëü |
Directed mutation 212 218—220bx
Directional cloning 326
DIRVISH 152
Dislodgment 272
Disulfide bonds 293
DMS protection assay 250t 251f
DNA 224
DNA damage 185—186t
DNA fingerprinting 158—189bx
DNA glycosylases 191t
DNA gyrase 397
DNA library 323 331—334
DNA library, gridded 153
DNA library, screening 323 334—336
DNA ligase 323 324 326 400
DNA methylase (methyl transferase) 93
DNA methylation 93—101
DNA methylation, bacteria 93—94
DNA methylation, control of transposable elements 96 170—171
DNA methylation, CpG/CpNpG in eukaryotes 94—101
DNA methylation, general role in gene regulation 95—97
DNA methylation, imprinting and X-chromosome inactivation 97—101
DNA microarrays 304
DNA modification 93
DNA polymerases 394 407
DNA polymerases in molecular cloning 324t
DNA polymerases, E. coli 394—395t
DNA polymerases, eukaryote 396—397t
DNA polymerases, thermostable 396 ch21
DNA primase 397
DNA profiling 158—159bx
DNA repair 187—199
DNA repair, error free 187—197
DNA repair, mutagenic 197—199
DNA replication 389—309
DNA replication by displacement 393
DNA replication, models 389
DNA replication, priming 404 405t
DNA replication, semiconservative 389—390
DNA replication, semidiscontinuous 390—391
DNA sequencing 161—163bx
DNA tumor viruses 259—260
DNA viruses 470—473
DNA, breathing 223
DNA, classified by function 137t
DNA, conformational polymorphism 223 230
DNA, helical morphology 228—230 233bx
DNA, sequence polymorphism 150 211
DNA, structure, double helix 228—230
DNA, structure, recognition by proteins 236
DNA, topology 232 233—234bx
DNA-binding motifs in proteins 237—243 237t
DNase I footprinting 250t 251f
DNase I hypersensitive site 40 454 462
Domain swap 247
Domains, of protein structure 290—292
Dominance 1—2 6—7 209
Dominance relationships 7—8t
Dominant negative (trans-dominant) 110 114 210
Dominant positive 210
Donation (trans-mobilization) of DNA 119
Donor conjugal DNA synthesis 118—119f
DOP-PCR 281
Dosage compensation 75
Dosage effects 45 207
Dosage repetition 301
Dot blot 357
Double minute chromosome 219
Down’s syndrome 48
Drosophila melanogaster, eye development 86—87
Drosophila melanogaster, homeotic genes 87—89bx
Drosophila melanogaster, model organism 145—146
Drosophila melanogaster, pattern formation in syncytial embryo 82—85bx
Drosophila melanogaster, segmentation 87—89bx
dsRNA-binding domain 243—244
E-site (exit site) of ribosome 314
Ectopic expression 210
Editosome 422
Edman degradation 307
Electrophoresis 355
Electroporation 330 349
Elongation factors, protein synthesis 316 317—318f
Elongation factors, transcription 458—459
Embryonic stem cells 364—365
Endosymbiont theory 268
Enhancement 10t 221
Enhanceosome 454
Enhancer 451—452
Enhancer trap 345
Entrapment vectors 344—351
Environment 13—15 17—18bx
Enzyme cascades, intracellular signaling 431
Enzyme mismatch cleavage 337
Epigenesis 65
Epigenetic gene regulation 95—101
Epigenetic information 93 127
Epimutation 95
Episomes 165
Epistasis 10t
Euchromatin 38
Exclusion mapping 148
Exon duplication 287 301
Exon phase, role in evolution 303
Exon shuffling 287 301
Exon skipping 416
Exon sliding 303
Exon trapping 155
Exons 137
Expressed sequence tag 155—156 281
Expression cloning 339—342
Expression cloning, E. coli 340—341
Expression cloning, eukaryote hosts 341—342
Expression cloning, native and fusion proteins 340—341
Expression linked copy 378
Expression vectors 340
Expressivity 8
F transfer region (tra operon, tra region) 124bx
F' plasmid 119
F-factor, in bacterial gene mapping 125bx
F-factor/F-plasmid 117—119 124bx
Fate maps 68
Fiber diffraction 308
Fiber FISH 152
Fidelity of replication 183—185
Field inversion gel electrophoresis 355—356
Filter hybridization 357—359
FISH 152
Flow sorting 333
FLP-FRP system 386
Fluctuation test 218
Fluorescence activated chromosome sorting (FACS) 333
Foldback elements 176 178
Foldon 94
Footprints of precisely excised transposons 173
Footprints of proteins 250—251
Forward mutation 209
Fos, c-fos gene 254—258 441
Fragile sites 52—53
Fragile-X syndrome 53 218
Frameshift fidelity 184—185
Frameshift mutation 205
fts mutants 22
Functional cloning 334—335
Functional genomics 304—305
Fusion protein 45 207 255—258 340—341
G-banding 58—59
G-protein coupled receptors 426—427
G-proteins, classes and activities 427t
G0 23
G1 and G2 gap phases 23
| Gain of function 209—211 350—352
Gap genes 83—84
GC content 134—135
Gel electrophoresis 323 355—356bx
Gel electrophoresis, large DNA molecules 355—356bx
Gel retardation assay 250t 251f
Gene amplification in cancer 255—258
Gene amplification, drug resistance 219
Gene amplification, expression vectors 342
Gene amplification, programmed 77 219
Gene augmentation therapy 365
Gene batteries 458
Gene conversion 208
Gene conversion, allelic 376
Gene conversion, in DNA repair 371
Gene conversion, in passive transposition 169—170
Gene conversion, information cassette switching 377
Gene density 138
Gene disruption 45 207
Gene dosage 45 207
Gene duplication and divergence 287 298—300
Gene duplication, mechanisms 299—300
Gene expression 111—113
Gene expression, prokaryote and eukaryote strategies compared 115—116
Gene families 297—304
Gene families, chimeric 300—303
Gene families, conventional 297—300
Gene fusion 45 207
Gene knock-in 352
Gene knockout 352
Gene locus 2 107
Gene mapping, bacteria 125
Gene mapping, eukaryotes 144—156
Gene mutation 201
Gene number 138
Gene product 111
Gene regulation 113—114
Gene regulation, global and narrow domain 114
Gene regulation, induction and repression 114
Gene size 137
Gene structure 106—107 137
Gene superfamily 297
Gene targeting 305 349—353
Gene therapy 349 352 365—366bx
Gene tracking 150
Gene transfer, bacterial 117—126
Gene trap 305 345
General transcription factors 447
Generic information 93 127
Generic markers 149—150t
Genes 2 103—110
Genes and cistrons, structure/function relationship 104—106
Genes, history of term 103
Genes, nomenclature 107—108
genetic code 127—131
Genetic code, properties 128t
Genetic code, universal 128f
Genetic code, variations in codon assignment 130t
Genetic linkage 9 373
Genetic mapping 144 146—151
Genetic mapping, quantitative trait loci 150—151
Genetic networks 215 305
Genetic screens 214
Genome 133
Genomes, physico-chemical properties 134—135
Genomes, structure and organization 133—144
Genomic libraries 332-333
Genomics 144—156
Genotoxic agents 185 187t
Genotype 2
Germinal mutation 201
Globin genes, mutations 216—217
Globin genes, transcriptional regulation 462—463
Greek key motif 291
Growth factors 425-426
Growth transformation 253
Guide RNA (gRNA) 422
Gypsy tansposon 41 180
Hairpin 230—231
Haploid number 134
Haploinsufficiency 210
Haplotype 374
HAPPY mapping 146—147f
Harlequin staining 59
Headful mechanism 472 474f
Hedgehog family proteins in vertebrate limb development 91—92bx
Hedgehog family proteins, Drosophila Hedgehog 87—89bx 138
Helicase 397 398t
Helix-loop-helix 241 246 291
Helix-turn-helix 237—239 291
Helmstetter — Cooper model 21—22
Hemoglobin disorders, molecular basis 216—217
Hemoglobinopathies 216-217
Hepatitis B virus 472
Hereditary persistence of fetal hemoglobin 217
Heredity 2
Heritability 18bx
Herpes simplex virus, infection cycle 486
Heterochromatin 38
Heterochromatin, role in gene silencing 42
Heterochronic mutations 74
Heterogeneous nuclear RNA (hnRNA) 411
Heterozygous 2
Hfr strains 119
High mobility group (HMG) proteins 37 239
Histones, core 37 241—242
Histones, histone fold 36 241—242
Histones, linker 36—37 242
Histones, modification 33 39—42
HIV infection cycle 485
HNF3/Fork head family 239
HO endonuclease 377
Holliday model 370—372
Homeodomain 238—239
Homeologous chromosomes 47
Homeotic genes 73 87—89bx 138
Homing introns and inteins 179
Homogeneously staining region 219
Homologous chromosome pairs 57
Homologous recombination, hotspots and coldspots 161
Homologous recombination, mechanism 369—372
Homologous recombination, molecular basis 372—373
Homologous recombination, regional frequency variation 161
Homologous recombination, role in genetic mapping 373—376
Homology 297
Homology-dependent gene silencing 114
Homopolymer tailing 327
Homozygous 2
Horizontal gene transfer 298
Host controlled restriction-modification systems 93—94
Hox genes 298
Hox genes in vertebrate limb development 91—92bx
Hox genes, vertebrate 89—90bx 138
Human genome project 145
Hybrid dysgenesis 175
Hydatidiform moles 49 97
Hydrogen bonds in nucleic acids 226—228
Hydrogen bonds in protein-nucleic acid binding 244—245
Hydrogen bonds in proteins 293—294
Hydrophobic core 293
Hypervariable minisatellite DNA 142
Hypochromic effect 357
Hypostasis 101
Illegitimate recombination 370 382—383t
Immediate early genes, cellular 33 440—441
Immediate early genes, viral 481 486
Immunoglobulin genes 386—387
Immunoglobulins 379 386—387
Immunoglobulins, diversity 379
Imprinting boxes 97
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