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Ridley A., Clark P., Peckham M. — Cell motility: from molecules to organisms
Ridley A., Clark P., Peckham M. — Cell motility: from molecules to organisms



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Íàçâàíèå: Cell motility: from molecules to organisms

Àâòîðû: Ridley A., Clark P., Peckham M.

Àííîòàöèÿ:

Recent advances in molecular and biophysical techniques, particularly fluorescence and live cell imaging, are revolutionizing the study of cell motility. New bioprobes not only reveal simple intracellular localization, but also contain details of post-translational modifications, conformational state and protein-protein interactions. Coupling these insights with complementary advances in genetic and biochemical methods is enabling scientists to understand the processes involved in cell motility - from molecular motors to cell movements in vivo in a range of organisms and cell types.

This book features landmark essays that provide an up to date and fascinating account of current research and concepts in cell motility.These cover the roles of molecular motors that drive movement and their interactions with the cytoskeleton as well as membrane dynamics that allow cells to change shape and to move.

Cell motility plays a key role in development - there are chapters on the genetics of cell migration, the regulation of contact repulsion in growth cones, and the progression from cell migration to cell-cell adhesion. Cell motility is directional - experts describe the molecules that regulate chemotaxis, allowing cells to migrate along pathways specified by chemical gradients. Finally, cell motility can be perturbed by mutation—metastasis occurs when cells lose their normal intercellular interactions and invade other tissue types. All these processes are regulated by signals from the environment, including other tissues in the body, and the various molecules that transmit and transduce these signals are discussed.

This book is a ‘must read’ for cell biologists working in a variety of fields, from development to wound healing, at all levels - post-doctoral fellows, post-graduate students and lab technicians. It is also stimulating reading for molecular and developmental biologists, biophysicists and biochemists.


ßçûê: en

Ðóáðèêà: Áèîëîãèÿ/

Ñòàòóñ ïðåäìåòíîãî óêàçàòåëÿ: Ãîòîâ óêàçàòåëü ñ íîìåðàìè ñòðàíèö

ed2k: ed2k stats

Ãîä èçäàíèÿ: 2004

Êîëè÷åñòâî ñòðàíèö: 342

Äîáàâëåíà â êàòàëîã: 10.12.2005

Îïåðàöèè: Ïîëîæèòü íà ïîëêó | Ñêîïèðîâàòü ññûëêó äëÿ ôîðóìà | Ñêîïèðîâàòü ID
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Ïðåäìåòíûé óêàçàòåëü
Cortactin, role in endocytosis      194
CRAC (cytosolic regulator of adenylyl cyclase)      30
Crawling cell locomotion, cell-matrix adhesions in      78—81
Crawling cells      175 254
Crib      157 250 255
Crk      120
Cross-linker proteins      78
Cross-talk between focal adhesions and microtubules      83
Cross-talk mechanisms      78
Cryo-electron microscopy      9
csA/gp80 null cells      23
Cy3-conjugated phosphotyrosine-specific acceptor antibody      122
Cyan fluorescent proteins (CFP)      118—120
Cytokinesis and dynamin      195—196
Cytoskeletal dynamics      127
Cytoskeletal stiffness and adhesion      291
D3-PI signalling pathway in chemotaxis, PTEN as negative regulator of      267—269
DAAM1      282
DAD      84
Darwinian model      10
DdCAD-1      22 28
DdCAD-1/gp24      22
DdM7      21 24 27—29
DdM7, relationship to M10      31—32
Delamination of migrating muscle precursors from the dermomyotome      325—327
Deleted in Colorectal Carcinoma (DCC)      7 311
Dematin      238
Dendritic nucleation model      141
Dendritic nucleation, array treadmilling hypothesis      2
Dendritic spine morphogenesis and dynamin      196—198
Dermomyotome (DM)      325—326
Desmosomal cadherins      103
Dextran Sodium Sulfate (DSS)      244
DGAP1 gene      252
Dia-interacting protein (DIP)      144
Diaphanous related formin homology proteins (DRF)      84
Dictyostelium      19 28 30 32 138 179 183 247—262 267
Dictyostelium amoebae      20
Dictyostelium amoebae, adhesion systems      21
Dictyostelium discoideum      20 39 44—52 251
Dictyostelium discoideum as powerful model organism      42—44
Dictyostelium M7 (DdM7)      26
Dictyostelium, actin dynamics in      252—253
Dictyostelium, adhesion receptors in      22—24
Dictyostelium, Arp2/3 complex regulation in      253
Dictyostelium, evolutionary implications      254—255
Dictyostelium, links between cytoskeleton and adhesion      24—28
Dictyostelium, WASp family proteins in      253
Differential interference contrast (DIC) imaging      104
DiI      309—310
Directed cell movement      153
Directional sensing      261—275
Dishevelled      282 287
Dorsal mesodermal tissues, pushing force generation      289—291
Downstream asymmetric signals      271—272
Drosophila      84 138 142 250 282 327
Drosophila melanogaster      137
Drosophila melanogaster shihire protein      190
Dyn1      192
Dyn2      192—193 195—197
Dyn2-GFP      190
Dyn3      192 197—198
Dyn3baa      197
Dynamic instability      77
Dynamin      189—201
Dynamin 1-GFP      125
Dynamin and actin-based vesicle trafficking      194—195
Dynamin and cytokinesis      195—196
Dynamin and dendritic spine morphogenesis      196—198
Dynamin, domain analysis      190
Dynamin, interaction with cortactin      192—193
Dynamin, overview      189—192
Dynamin, participation in actin-based membrane dynamics      193—194
Dynamin, postsynaptic      197
Dynamin-actin-membrane interface      198
Dynein-dynactin complex      88—89
E-cadherin      170
E-cadherin distribution during cell-cell adhesion      104—106
E-cadherin function during cell-cell adhesion, mechanistic insights      106
E-cadherin GFP      104-105
E-cadherin, oligomerization of      123
E-cadherin, TX-insoluble      104
EB1      88 90
EFA6 (Exchange Factor for ARF6)      168
EGF      136
EGF receptor      7 180 184 224 318
EGF receptor in MTC cells      177
EGF receptor signalling      178
EGF receptor, actin-associated      181
EGF receptor, autophosphorylated      182
EGF receptor-associated actin polymerization      181—182
EGF, chemotactic responses to      177
EGF, chemotaxis to      175—179
EGF, motility cycle of carcinoma cells in response to      181
EGF, postulated signalling pathways in response to      185
EGF-coated beads      122
Electron microscopy      1 10
Ena/VASP proteins      24 135 144—147
Endocytic pathway      170
Endophilin      192
Endothelial cells      62 205
Endothelial sprouting      64
Entamoeba histolytica      48
Eph      328
Eph receptor activation      61—62
Eph receptor activation by soluble ephrins      65
Eph receptor signals during migration of muscle precursor cells      328
Eph receptor tyrosine kinases      62
Eph receptor-ephrin activation      69
Eph receptor-ephrin interaction      61 62 69
Eph receptor-ephrin mediated control of cell segregation      63—64
Eph receptor-ephrin regulation of axon guidance      62—63
Eph receptor-ephrin signalling      64
Eph receptor-expressing neurons      71
Eph receptors      62
Eph-ephrin signalling      61
EphA receptors      70
EphA4      62 328
EphA7      61 65
EphA7, ephrin-A4 activation of      66
EphB2      61 65 323
EphB4      63—64
Ephrin induced growth cone collapse, Rho GTPases role in      67—71
Ephrin regulated contact repulsion of growth cones      61—74
Ephrin-A      62 70
Ephrin-A2      63
Ephrin-A4 activation of EphA7      66
Ephrin-A4-Fc      65
Ephrin-A5      63 67—68
Ephrin-A5, ectopic expression      328
Ephrin-A5, induced growth cone collapse      69
Ephrin-A5-Fc      61 68
Ephrin-B      62
Ephrin-B1-Fc      65
Ephrin-B2      63—64
Ephrin-expressing fibroblasts      71
Ephrin-signalling pathway      71
Ephrins      62
Epidermal growth factor      see “EGF”
Epithelial cells      62 203—204
Epithelial cells, brush border      236
Epithelial cells, cell-cell and cell-extracellular matrix contacts      102
Epithelial cells, leading edge protrusion in      206
Epithelial layer      204
Epithelial tubulogenesis      160
ErbB receptors      318—319
ErbB2      319
ErbB2/ErbB3 receptors      320—321
ErbB3      319 321
ErbB4      319
ErbBl receptor activation dynamics      121
ErbBl-GFP      122
ERK-mediated phosphorylation      225
ERK1      262 269
ERM proteins      25
Escherichia coli      23
Eukaryotic cells      153 203
Eukaryotic lineage      4
EVH1      144
EVH2      144
Extension      277—297
Extension by shape change, oriented division and growth      286
Extension in sandwich explants      287
Extension, active, force-producing      285
Extension, diversity and complexity of      283—286
Extracellular matrix (ECM)      76 78—79 90—91 160 222 306 309
Extracellular matrix (ECM) and cell intercalation      292—293
Ezrin      122
Ezrin-VSVG      122
F-actin      25 45 53 181—182 195 198 235 237 262
FAK      29 222—223 227 299 301 304 306
FERM domain      19 25 27 29 31—32
FERM proteins      26
FH1      84—85 143—144
FH2      84—85 143
FH3      84
Fibre assembly and disassembly      77
Fibrillar adhesions      79 82
Fibroblast cells      71
Fibroblast cells, assembly of filamentous actin structures in      65
Fibroblast cells, ephrin-A-expressing      69
Fibroblast motility      204
Fibroblast, ephrin-expressing      70
Fibroblast-like cells      63
Fibroblasts      203
Fibroblasts, actin reorganization in      66
Fibroblasts, centrosome reorientation      208
Fibroblasts, defects in migration      304
Fibroblasts, inhibiting calpain in      227
Fibroblasts, migrating in vitro      309
Fibroblasts, Rho GTPase manipulation in      67
Fibronectin-containing matrix      287
Filo-lamelliform protrusive activity      287
Filopodia      61 67—68 135 290
Filopodia, formation      142
Fimbrin      236
Fish keratocytes      79
Flap      117 127—132
FLAP, image acquisition      128—131
FLAP, image processing      128—131
FLAP, pre-bleach images      130—131
Fluorescence lifetime imaging (FLIM)      117 119—122
Fluorescence localization after photo-bleaching      see “FLAP”
Fluorescence microscopy      1
Fluorescence recovery after photobleaching      see “FRAP”
Fluorescence resonance energy transfer      see “FRET”
Fluorescence speckle microscopy (FSM)      117 125—127
Fluorophores      117—118
FM      4—64 307
FMLP      183
Focal adhesion as mechanosensor      80
Focal adhesion kinase      see “FAK”
Focal adhesion, disassembly      225—227
Focal adhesions      75—99 222
Focal adhesions, disruption      82
Focal adhesions, mechanosensory function      81—83
Focal adhesions, roles of actin and microtubule systems      92
Focal adhesions, tension-dependent growth      83
Focal complexes      82 228
For3      85
Formyl-Met-Leu-Pha (f-MLP)      263
FRAP      82 127—128
FRET      90 117—120 272
G-actin      53
G-protein-coupled receptors      see “GPCR”
GAB      325
Gab1      324—327
Gamma-tubulin      77
Gastrulation      277—279
GDP      204
GDP/GTP exchange      168
GDP/GTP nucleotide switch      166
GEFs      112 168
Gelsolin family      236 240 242
Gelsolin/villin superfamily, domain structure      237
GFP      117—118 123 127 176 262 290 299 301 304 307 309 313
GFP, multicoloured variants      120
GFP-CD44      122
GFP-tagged proteins      104
GFP-VASP      24
GIT1      309
Glial cell line-derived neurotrophic factor (GDNF)      323
Glutamate receptor endocytosis      197
Gly      45
Glycosylphosphatidylinositol (GPI) anchor      23 62
gp80      23
GPCR      225 262
GPCR, downstream effectors during chemotaxis      261—275
GPCR-mediated lipid signalling in chemotaxis of ameoboid cells      262—263
GPR loop      53
Grb2      9 64 325
Grb4      64
Green fluorescent protein      see “GFP”
Growth cones, ephrin regulated contact repulsion of      61—74
Growth factors      176
GTP      204
GTP hydrolysis      12
GTPase activators (GAPs)      12—13
GTPase binding domain (GBD)      7—8 139
GTPases      41 65
Guanine exchange factors      111
Guanine nucleotide exchange factor      167
Harmonin      27
Hepathocyte growth factor (HGF)      160 235 239—240
Homeobox gene      327—328
Homo sapiens      137
HSPC300      141
Hyla regilla      279
Inflammatory bowel disease (IBD)      244
Initial asymmetric signal      271—272
Integrin receptors      222
Integrin-containing adhesive contacts      220
Integrin-cytoskeletal linkage      304
Integrin-dependent cell-matrix contact      80
Integrin-mediated cell migration      220
Integrins      25 300
Interference reflection microscopy (IRM)      25 129
Intersectin      192
Intracellular trafficking of adhesion molecules      306—309
Invagination process, dynamics of      123
IQGAP      90 112 213
IRSp53      112 157—158
K.aerogenes      23
Keratinocytes      106
KKEK motif      238
KT5926      81
Lamella collapse      61 69
Lamelliform protrusions      279 286 300
Lamellipodia      61 66 72 135
Lamellipodia activity      65 108
Lamellipodia dynamics      102
Lamellipodia formation      107
Lamellipodia protrusion      136
Lamellipodia protrusion, EphB2 and EphA7 induced      65—67
Las17p      50 53
Lateral membrane      103
Latrunculin A      198
Lbx1      327—328
Leading edge protrusion in epithelial cells      206
Ligand binding      318
1 2 3 4
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