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Hodgson E. — A Textbook of Modern Toxicology
Hodgson E. — A Textbook of Modern Toxicology



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Название: A Textbook of Modern Toxicology

Автор: Hodgson E.

Аннотация:

Hodgson (toxicology, North Carolina State University) provides an accessible overview of toxicology, suitable for junior and senior undergraduate courses in environmental, pharmacological, medical, and veterinary toxicology. The text emphasizes the biochemical aspects of toxicology at the cellular and molecular levels, and readers are assumed to have some background in chemistry, biochemistry, and animal physiology. In this third edition, new contributors describe the latest work in their respective areas of specialization and discuss emerging topics such as molecular biological aspects of technology. A glossary and a summary section are included.


Язык: en

Рубрика: Медицина и здравоохранение/

Статус предметного указателя: Готов указатель с номерами страниц

ed2k: ed2k stats

Издание: Third edition

Год издания: 2004

Количество страниц: 582

Добавлена в каталог: 12.05.2005

Операции: Положить на полку | Скопировать ссылку для форума | Скопировать ID
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Предметный указатель
Hypothyroidism      310 311 313 314
Ibuprofen      123
ICH      258
Ifosfamide      122
Imipramine      122 129 138 265
Immune suppression      330—334
Immune system      327—330
Immune system, developing      341
Immunoaffinity purification      20
Immunoassay      404
Immunochemical techniques      19—21
Immunolocalization      20
Immunosuppresive agents      239
Immunotoxicity      see Toxicity
Imposex      473 474
In vitro      523 533
In vivo      523 533
Indomethacin      176 265
Induction      190 198 310 533
Industrial chemicals      7
Industrial toxicology      see Toxicology
Inhalation toxicity testing      357
Inhibition      60 155 185—188 224 310 533
Initiation      241 534
Initiation-promotion model      241—242
Inner cell mass      252
Instrument calibration      26
Insulin      171
Intoxication      534
Involution      254
ion channels      222
Ionization      86—87 490
Ionizing radiation      200
Ipomeanol      323
Iproniazid      265
Iron      4 165 166 318
Irritation      318 320
Isoniazid      265
Isoniazid and polymorphisms      182
Isotetrinoin      256
Isozymes      534
Kanamycin      276
Kepone      307 313
Ketaconazole      310
Ketamine      122
Ketone reduction      134
Kidney      273 205 206 see
Kidney, cortex      273
Kidney, damage      274
Kidney, Kidney, medulla      273
Kidney, papilla      273
Koch's postulates      511
Kupffer cells      263
Laboratory information management system (LIM)      25
LC50      217 470 471 525 534
LD50      215 217 359—362 470 471 525 534
Lead      38 41 47 51 275 285 287 290
Legislation      411
Lethal synthesis      534
Libido      300
Lidocaine      123
Light, metabolic effects      200
Lindane      222 466
Lipid      204
Lipid oxidation      264
Lipid peroxidation      153 157 266 269 270 274 322
Lipid, effect on metabolism      164
Lipophilic      467 534
Lipoproteins      264 270
Liver and elimination      206. 207 209
Liver function      263
Liver, fatty      264—265
Liver, injury      263—268
Liver, structure      263
Liver, susceptibility to toxicants      264
LOAEL      see Lowest observed adverse effect level
Local lymph node assay      337—338
Loop of Henle      206 273
Lovastatin      123
Lowest observed adverse effect level (LOAEL)      427 473
Lungs      see Respiratory system
Lymphocytes, B      19—20
Lysosomes      16 275
Magnesium      4
Malathion      181 473
Malformations, developmental      376—378
Mallard duck      394
Manganese      4 386
Maximum containment level (MCL)      412
Maximum containment level goal (MCGL)      412
Maximum tolerated dose (MTD)      223 249 370 535
MCGL      see Maximum containment level goal
MCl      see Maximum containment level
Mechanism of action      535
Membranes      83 270 276 322 535
Mepazine      265
Mephenytoin      122
Mephobarbital      122
Mercaptopurine      265
Mercapturic acids      143 166
Mercury      41 44 47 52 205 275
Mesocosm      394
Mesothelioma      321 322
Mestranol      265
Metabolic activation      see Activation
Metabolism of toxicants      see toxicants
Metabolism testing      382
Metallothionein      51 53 275
Metals      4 49—54
Metals and nephrotoxicity      275—276
Metals speciation      492—493
Methadone      122
Methandrolone      265
Methanol      152 155
Methimazole      265
Methiocarb      126 129
Methiochlor      126
Methionine      129
Methoprene      308
Methoprinic acid      308
Methoxyfluorane      122 265
Methyl mercaptan      125
Methyldopa      265
Methylenedioxy ring cleavage      127
Methylenedioxyphenyl synergists      4
Methylmercury      289 290
Methyltransferase      141
Metyrapone      185
Microbial toxins      66
Microglia      284 290
Micronucleus test      391
Micronutrients, effects on metabolism      164
Microsomes      122 535
Midazolam      123
Milk      204
Minimum risk levels (MRL)      427
Mirex      464 470
Mitochrondria      16 275
Mitomycin      265
Mode of action      535
Moisture, effects on metabolism      200
Molecular methods, in toxicology      13—22
Molybdenum hydroxylases      112
Monoamine oxidase      131 284 290
Monoclonal      225—226
Monocrotaline      322
Monooxygenase      535
Motility, gut      300
MPTP      see 1-Methyl-4-phenyl-1
MRL      see Minimum risk level
MTD      see Maximum tolerated dose
Multidrug-resistance associated protein      209
Multigeneration study      372—374
Mutagenesis      6 535
Mutagenicity assays      249 385—393
Mutagenicity study requirements, under FIFRA      393
Mutagens      121
Mutation(s)      237—239 248—249
Mutation(s), transition      248—249
Mutation(s), translation      248—249
Mycotoxins      66 535
Myelin      281 287 289—290
N-, O-, S-Methylation      141 142
N-Acetylcysteine      154
N-Acetyltransferase      146 525
N-Benzylamidazole      130
N-Hydroxy-2-acetylaminofluorine      139
naphthalene      121 123 137
Naphthylamine      121 268
Narcosis      220 472
National environmental policy act      414
National institute for occupational safety and health (NIOSH)      414 418
NCTB      see Neurobehavioral core test battery
Necrosis      266 321
Neomycin      276
Nephron      206 273
Nephrotoxicity      see Toxicity
Neurobehavioral core test battery (NCTB)      293—294
Neurotoxicity      see Toxicity
Neurotransmitter receptors      280 282—283 289 297
Neurotransmitter release      281—282 283 292 297
Neurotransmitter reuptake      285 290
Nevirapine      122
Niacin      165 166
Nickel      318
Nicotine      122 129 130 141 173
Nifedipine      123
NIOSH      see National institute for occupational safety and health
Nitrates      42
Nitro reduction      112 133 180
Nitroaromatics      220
Nitrobenzene      134
Nitrogen oxides      37 318
No observed adverse effect level (NOAEL)      426
No observed effect level (NOEL)      10 472 525 536
NOAEL      see No observed adverse effect level
Nonpoint sources      480—482
Nonsteroidal anti-inflammatory drugs (NSAIDs)      139
Noradrenaline      142
Norepinephrine      142
Nornicotine      141
Northern blot analysis      18
Nuclear magnetic resonance      460
Nuclear receptors      see Receptors
Nucleophile      149
Nucleus      16
Occupational safety and health act      413
Occupational safety and health administration      354 413 418 536
OECD      367
Oligodendrocyte      281 284
Omeprazole      122
Oncogenes      227 245—247 536
OPIDN      see Organophosphate-induced delayed neuropathy
Organ toxicity      6
Organochlorine insecticides      57—58
Organogenesis      371 374—378
Organomercurials      275
Organophosphate-induced delayed neuropathy (OPIDN)      288
Organophosphorus insecticides      58—60 220 221 288 290—292 408 471 477
Organophosphorus insecticides, aging      291—292
Ornithine      178
OSHA      see Occupational safety and health administration
Ovaries      300 346
Oxazepam      138
Oxidation, N-, S-, and P-      112 126 127
Oxidative deamination      126
Oxidative phosphorylation      536
Oxidative stress      267 268 536
Oxygen consumption      300
Ozone      37 318
p-Chlorobenzaldehyde      134
p-Chlorothiophenol      141
P-Glycoprotein      209
p-Nitroanisole      124
p53      245 247—248
Paclitaxel      123
Pantothenic acid      165 166
Papaverine      265
Paracelsus      9 216
Paraoxon      127 152
Paraquat      181
Parasympathetic nervous system      280 291
Parathion      58 59 127 152 155 465 466
Parkinson’s Disease      285 286 289 290
Partition coefficient      81 87—88 536
Partitioning      487
Partitioning, equilibrium      487
Partitioning, lipid-water      488
Partitioning, octanol-water      488
Partitioning, particle-water      489
Passive avoidance      383
Passive diffusion      see Diffusion
PBB      312
PBPK      see Physiologically based pharmacokinetic model
PCB      see Polychlorinated biphenyls
PCR      see Polymerase chain reaction
Pentachlorophenol      224
Peroxisome proliferators      197
Peroxisome proliferators-activated receptor-$\alpha$ (PPAR$\alpha$)      197
Persistence, environmental      464
Pesticides      42 54—64
Pesticides, classification      56
Petroleum      472
Pharmacokinetics      78 537
Phase I reactions      111—137 174 537
Phase II reactions      137—148 165 166 174 176 177 206 529 537
Phenanthrene      464
Phenindione      265
Phenobarbital      123 191 222 239 242
Phenobarbital-responsive enhancer module (PBREM)      194
Phenol      177 178 311
Phenylbutazone      174 265
Phenytoin      123
Phorate      126 129
Phorbol 12-myristate 13 acetate (PMA)      239 242
Phosgene      156 277 318
Phosphate conjugation      147
Phospholipids      264 276
Phosphorus      265
Photolysis      465 494
Phthalate      313
Physicochemical properties, and diffusion      85—88
Physiologically based pharmacokinetic model (PBPK)      436
Phytotoxins      68
Piperonyl butoxide      4 127 185 189
Pituitary      301 302 170 171
PMA      see Phorbol 12-myristate 13 acetate
Point sources      480—482
Poison      see also Toxicant
Poison, definition      3 537
Pollution      33 40 419 537 541
Polychlorinated biphenyls (PCBs)      43 204 265 309 311 314 464 468 470 476
Polycyclic aromatic hydrocarbons      71 73 121 243 249
Polymerase chain reaction (PCR)      18
Polymorphisms      181 230
Polyploidy      248
Polyvinyl chloride      345
Poor metabolizers (PM)      122
Portals of entry      4 537
Potentiation      see Synergism and potentiation
1 2 3 4 5
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