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Hodgson E. — A Textbook of Modern Toxicology
Hodgson E. — A Textbook of Modern Toxicology



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Название: A Textbook of Modern Toxicology

Автор: Hodgson E.

Аннотация:

Hodgson (toxicology, North Carolina State University) provides an accessible overview of toxicology, suitable for junior and senior undergraduate courses in environmental, pharmacological, medical, and veterinary toxicology. The text emphasizes the biochemical aspects of toxicology at the cellular and molecular levels, and readers are assumed to have some background in chemistry, biochemistry, and animal physiology. In this third edition, new contributors describe the latest work in their respective areas of specialization and discuss emerging topics such as molecular biological aspects of technology. A glossary and a summary section are included.


Язык: en

Рубрика: Медицина и здравоохранение/

Статус предметного указателя: Готов указатель с номерами страниц

ed2k: ed2k stats

Издание: Third edition

Год издания: 2004

Количество страниц: 582

Добавлена в каталог: 12.05.2005

Операции: Положить на полку | Скопировать ссылку для форума | Скопировать ID
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Предметный указатель
Cross resistance      529
Crotalaria spectabilis      323
Cyanide      173 223
Cycasin      159 160 265
Cyclodiene insecticides      222
Cyclohexamide      265
Cyclooxygenases      132
Cyclophosphamide      122
Cyclosporine A      123
CYP      see Cytochrome P450
Cysteamine      129
Cysteine conjugate $\beta$-lyase      see $\beta$-Lyase
Cytochrome b5      115
Cytochrome P450 (CYP)      271 272 274 277 310 318 322 323 324
Cytochrome P450 (CYP), classification      117
Cytochrome P450 (CYP), CYP1      119
Cytochrome P450 (CYP), CYP19      310
Cytochrome P450 (CYP), CYP1A1      119 121
Cytochrome P450 (CYP), CYP1A1, induction      191 199
Cytochrome P450 (CYP), CYP1A2      119 121
Cytochrome P450 (CYP), CYP1A2, induction      192
Cytochrome P450 (CYP), CYP1B1      119
Cytochrome P450 (CYP), CYP2      119 122
Cytochrome P450 (CYP), CYP2A6      122
Cytochrome P450 (CYP), CYP2B, regulation      191 194
Cytochrome P450 (CYP), CYP2B6      122
Cytochrome P450 (CYP), CYP2C      122
Cytochrome P450 (CYP), CYP2C19      122
Cytochrome P450 (CYP), CYP2C8      122
Cytochrome P450 (CYP), CYP2C9      122
Cytochrome P450 (CYP), CYP2D6      182
Cytochrome P450 (CYP), CYP2E1      123 170
Cytochrome P450 (CYP), CYP2E1, regulation      192 197
Cytochrome P450 (CYP), CYP3A, regulation      191 196 197
Cytochrome P450 (CYP), CYP3A4      123 323
Cytochrome P450 (CYP), distribution      116
Cytochrome P450 (CYP), evolution      117
Cytochrome P450 (CYP), families      119—123
Cytochrome P450 (CYP), induction      123
Cytochrome P450 (CYP), multiplicity      116
Cytochrome P450 (CYP), nomenclature      117
Cytochrome P450 (CYP), purification      116
Cytochrome P450 (CYP), reactions      112 123—128
Cytochrome P450 reductase      114 132 324
Cytosol      113
Cytotoxicity      see Toxicity
DDE      174 204 348
DDT      57 58 137 198 204 222 307 309 348 464 465 468
DDT dehydrochlorinase      136
Deacetylation      147
Dealkylation (O-, N-, and S-)      112 124 465
Debrisoquine, and polymorphisms      182
Degradation, abiotic      465
Degradation, biotic      465
Dehalogenation      112 465
Dehydrogenation      112
Delaney amendment      see Food drug
Demeton      126
Dendrites      280
Dermal irritation tests      363
Dermal sensitization tests      363
Dermal, subchronic toxicity studies      369
DES      see Diethylstilbestrol
Desulfuration      112 127
Detectors, conductivity      453
Detectors, electron capture      453
Detectors, flame ionization      452
Detectors, flame photometric      453
Detectors, gas-chromatographic      452
Detoxication      529
Detoxification      529
Development      300
Developmental toxicity      see Toxicity
Developmental toxicology      see Toxicology
Dexamethasone      123 191 196
Diabetes, CYP2E1 induction in      197 198
Dialkyl nitrosamines      265
Diamine oxidase      132
Diazepam      265
Diclofenac      123
Dicofol      465
Dicoumarol      224
Dieldrin      57 58 124 222 476
Dietary administration, in toxicity testing      365
Diethylmaleate      144 185
Diethylstilbestrol (DES)      256 299 306 310 312 345
Diethyltoluamide (DEET)      122
Diffusion      80
Diffusion between phases      486
Diffusion in environment      485—487
Diffusion, passive      80 203
Digitoxin      123
Dihydrotestosterone      345
Dimethoate      175
Dimethyl sulfoxide      126
Dimethylamine      128
Dimethylaniline      129
Dimethylbenzanthracene      121 265
Dimethylnitrosamine      265
Dioxin(s)      43 311 314
Diphenylmethylphosphine      127
Disease, metabolic effects      171
dispersion      485
distribution      77—110 529
Disulfide reduction      133
Disulfiram      122 133 134 185 186
Diurnal rhythms, metabolic effects      172
DNA, adducts      240—241 243—245 384
DNA, binding      270
DNA, cDNA libraries      17
DNA, damage      237—238 322 389
DNA, recombinant      16
DNA, repair      240—241 245 389
DNA, unscheduled synthesis test      389
Dominant lethal test      392
Dopamine      140
Dosage      529
Dose extrapolation      249 233—234
Dose selection, for chronic studies      370
Dose-response      4 10 217—220 426—427 529
Draize test      see Eye irritation test
Drospophila      388
Drug analysis      405
Drug analysis flowchart      405
Drugs of abuse      7 71 72 530
Drugs, therapeutic      70 417 530
E. coli      386
EC50      217
Ecdysone receptor      see Receptors
Ecotoxicology      see Toxicology
ED50      217
Edema      318
EDSTAC      see Endocrine disruptor screening and testing advisory committee
Education      420
Electrolyte balance      273
Electron transport system, definition      530
Electron transport system, inhibitors      530
Electrophilic      149 240 530
Electrophoresis, capillary      454
Elimination of toxicants      see Toxicants
Embryology, mammalian      252
Emphysema      318 321
Endocrine disruptor screening and testing advisory committee (EDSTAC)      415
Endocrine disruptors      347 415
Endocrine system      299—315
Endocytosis      276
Endoplasmic reticulum      16 113 531
Endosulfan      126 473
Enterohepatic circulation      208—209 531
Environmental fate      479—499
Environmental fate models      479 497—498
Environmental Protection Agency      354 411—416
Environmental transport      479—499
Epidemiology      6
Epigenetic carcinogen      see Carcinogen
Epinephrine      142
EPN      185 189
Epoxidation      112 123 151
Epoxide hydrolase      112 135 180
Erythromycin      123
Ester cleavage      127
Esterase(s)      112 175
Esterase(s) and selectivity      180
Esterase(s), A      135
Esterase(s), B      135
Esterase(s), C      135
Estradiol      265 300 304 305 306 307 311 312
Estrogen receptor      see Receptors
Estrogens      119 300
Estrone      140
Ethanol      123 191 257 270 408
Ethinyl estradiol      123
Ethionine      265
Ethylene glycol      407
Ethylmorphine      125
Ethylnitrosourea      345
Excretion, biliary      176
Expert witness      400
Exposure      216
Exposure assessment      425 507—509 523 531
Exposure to environmental stress      508—509
Extraction      447
Extraction, supercritical fluid      448
Extrapolation, animal to human      354 362
Eye irritation test      531
Fatty acid(s)      153
FDA      see Food and drug administration
Federal insecticide, fungicide and rodenticide act (FIFRA)      393 414 531
Fenarimol      310
Fertility      258 300
Fetal alcohol syndrome      257 532
Fibrosis      318 321
Field tests      394—395
FIFRA      see Federal insecticide fungicide
First order kinetics      82
Fish odor syndrome      128 183
Flavin-containing monooxygenase (FMO)      112 169 170 183 318 324
Fluoroacetamide      175
FMO      see Flavin-containing monooxygenase
FOB      see Functional observation battery
Fonofos      129
Food additives      7 64—65 532
Food allergy      341
Food and drug administration (FDA)      258 354 413
Food chains, environmental      12
Food contaminants      64—65 532
Food quality protection act      415
Food, drug and cosmetics act      413 532
Forensic toxicology      see Toxicology
Formaldehyde      152
Formic acid      152
Free radicals      151 153 270 532
Fumigants      64
Function observational battery      293 295
Functional observation battery (FOB)      379—380
Fungicides      63
Furans      314
Fusarium solani      323
Future considerations, environmental      521
Future considerations, human health      521
GABA      see $\gamma$-aminobutyric acid
Gait      383
Galactosamine      265
Gall bladder      263
Gastrula      252
Gender, metabolic effects      168
Gene, amplication      245
Gene, expression      19
Gene, function      19
Gene, regulation      19
Generally regarded as safe (GRAS)      533
Genetic alterations      237—239 243
Genetic instability      248
Genetic polymorphisms      see Polymorphisms
Genomic libraries      17
Genotoxic carcinogen      see Carcinogen
Genotoxicity      see Toxicity
Genotoxicity assays, short assays      249 385—393
Gentamycin      276
Germ cells      345
GFAP      see Glial fibrillary acidic protein
Ginger jake      288
Glial fibrillary acidic protein (GFAP)      290 296
Glomerular capsule      206
Glomerulus      206
Glucocoricoids      300
Glucocorticoid receptor      see Receptors
Glucoside conjugation      139
Glucuronic acid      209
Glucuronidation, developmental effects      167
Glucuronide conjugation      138
Glucuronosyl transferase      138
Glutathione      143 209
Glutathione conjugation      143 144 167 180 277 208
Glutathione S-transferase      see Glutathione conjugation
Glycine      146
Glycine conjugation      167
Good laboratory practice      533
GRAS      see Generally regarded as safe
Growth      300
Growth hormone      168 300
Gynacomastia      306 312 313
Hair      205
Halogenated hydrocarbons      249
Halothane      122 265
Hazard assessment      464 523
Hazard identification      424
Hazard quotient      432
Henry’s law      487—488
Hepatic artery      207 263
Hepatic elimination      207—210
Hepatic portal vein      263
Hepatitis      267
Hepatocytes      207 263—272
Hepatotoxicant(s)      3 4 263—272
Hepatotoxicity      see Toxicity
Herbicides      62
Hexachlorobenzene      466 476
Hexachlorobutadiene      277
Hexane      288
Hexobarbital      174 183 186
HGPRT test      387
Histamine      182
Homeostasis      273
Hormesis      219 426
Hormone      239 240 242
Hormone, clearance      310
Hormone, synthesis      310
Household chemicals      417
Human genome project      16
Human health risk assessment      see Risk
Hydrogen fluoride      318
Hydrogen sulfide      223
hydrolysis      135 465 493
Hydroxyacetanilide      141
Hydroxyl radical      322
Hydroxylation      112 206
Hypersensitivity      335
Hypothalamus      170 300 301 302
Hypothalamus-pituitary-gonadal axis      344
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