These notes are written for a one-semester calculus course which meets three times a week and is, preferably, supported by a computer lab. The course is designed for life science majors who have a precalculus back ground, and whose primary interest lies in the applications of calculus. We try to focus on those topics which are of greatest importance to them and use life science examples to illustrate them. At the same time, we try of stay mathematically coherent without becoming technical. To make this feasible, we are willing to sacrifice generality. There is less of an emphasis on by hand calculations. Instead, more complex and demanding problems find their place in a computer lab. In this sense, we are trying to adopt several ideas from calculus reform. Among them is a more visual and less analytic approach. We typically explore new ideas in examples before we give formal definitions.