The objective of this book is to assist the experienced chromatographer, who is already familiar with chromatography fundamentals and modern instrumentation, in obtaining useful quantitative results from Column Liquid Chromatography (LC). LC includes both High Performance Liquid Chromatography (HPLC) and Size Exclusion Chromatography (SEC) (also known as Gel Permeation Chromatography (GPQ). To accomplish this objective, quantitative methods now utilized in LC are reviewed and assessed. These methods consist of a wide variety of ways of mathematically treating LC data and are now proliferating with the development of microprocessor-assisted chromatography instrumentation. Furthermore, they are not limited to direct determination of concentration or molecular weight information from chromatograms.