This book constitutes the refereed proceedings of the Second International Workshop on Autonomous Intelligent Systems: Agents and Data Mining, AIS-ADM 2007, held in St.Petersburg, Russia in June 2007.The 17 revised full papers and 6 revised short papers presented together with 4 invited lectures were carefully reviewed and selected from 39 submissions. The papers are organized in topical sections on agent and data mining, agent competition and data mining, as well as text mining, semantic Web, and agents.