The past two years have seen significant interest and progress made in national and homeland security research in the areas of information technologies, organizational studies, and security-related public policy. Like medical and biological research, which is facing significant information overload and yet also tremendous opportunities for new innovation, the communities of law enforcement, criminal analysis, and intelligence are facing the same challenge. As medical informatics and bioinformatics have become major fields of study, the science of “intelligence and security informatics” is now emerging and attracting interest from academic researchers in related fields as well as practitioners from both government agencies and industry.