This volume in the series of Topics in Current Chemistry attempts to familiarize the synthetic organic community with a number of important new developments in the Biocatalysis arena in consideration of both enabling and able technologies. A number of leading contributors from the forefront of this exciting technology address the state of the art of biocatalysis in eight authoritative and timely reviews, from discovery through development to application. Recent landmark advances in molecular biology have the potential to profoundly alter the shape of the field of applied biocatalysis and the pace of its future progress at the beginning of the next millenium.