Grzimek's Student Animal Life Resource: Reptiles offers readers comprehensive and easy-to-use information on Earth's reptiles. Entries are arranged by taxonomy, the science through which living things are classified into related groups. Each entry includes sections on physical characteristics; geographic range; habitat; diet; behavior and reproduction; reptiles and people; and conservation status. Family entries are followed by one or more species accounts and a range map and photo or illustration for each species. Entries conclude with a list of books, periodicals, and Web sites that may be used for further research.

Both volumes of Grzimek's Student Animal Life Resource: Reptiles includes a pronunciation guide for scientific names, a glossary, an overview of reptiles, a list of species in the set by biome, a list of species by geographic location, and an index. The set has nearly 200 full-color maps, photos, and illustrations to enliven the text, and sidebars provide additional facts and related information.