Aimed at new users of quadrupole devices as well as scientists, researchers and students working in analytical laboratories, this comprehensive reference provides concise descriptions of the theory of ion motion and the principles of operation. This second edition has been revised to reflect scientific and technological advances and new applications in the field. New chapters have been added covering new ion trap instruments of high sensitivity; peptide analysis by liquid chromatography/ion trap tandem mass spectrometry; analytical aspects of ion trap mass spectrometry combined with gas chromatography; simulation of ion trajectories in the ion trap; and the Rosetta mission.