In this new edition of their textbook, Cooper (emeritus, pharmacology, Yale U.), Bloom (neuropharmacology, The Scripps Research Institute), and Roth (pharmacology and psychiatry, Yale U.) retain the structure of earlier editions, introducing the biochemistry and physiology of nervous tissue before moving on to individual discussions of the various neurotransmitters. Discussions of drugs are included as they relate to the particular neurotransmitter under examination.