The management of orthopedic infection is an area of growing importance in orthopedic surgery. This text provides a complete overview from basic research to clinical application and future perspectives in the treatment of orthopedic infection emphasising the role of local therapy. The unprecedented collection of experiences of the major experts in the field supplies the reader with long-awaited guidelines for treatment. Covering the various approaches to the treatment of orthopedic infections, it will be an important tool for the daily practice of its readers.