This handsomely bound volume contains more than 30 biochemistry articles initially published online by Annual Reviews in 2004. It opens with Alexander Rich's (biology, MIT) reflections on a long career in molecular biology. Written by leading academic researchers, other contributions address such topics as the directed evolution of nucleic acid enzymes; the molecular mechanisms of mammalian DNA repair; nuclear magnetic resonance spectroscopy of high-molecular- weight proteins; and the GoLoco motif in cell division.