Ten years after the publication of Regenerative Nephrology, the second edition of the book has been conceived and completed. This revised and expanded edition has been motivated by the changing landscape of the field of regen- eration, which reflects a multitude of discoveries made during the past decade, rotating investigative windmills of regenerative medicine and nephrology. At times, those may seem to be quixotic, but auspiciously, their blades appear to begin harvesting energy from the winds of change.