Responsibility is a cross-cutting concept which raises questions at multiple levels of analysis. It is also increasingly invoked in political debates as many challenges of our time are characterized by insecurities when responsibilities cannot easily be attributed.The questions of who should be responsible and what for are embedded in a broader normative context that points towards issues of authority and legitimacy, which in turn can have legal, social and/or material dimensions. Similarly, those who invoke responsibility in the first place can also become subject to analytic scrutiny.With so many dimensions simultaneously at play, addressing the different analytical questions around responsibility requires a calibrated compass and an up-to-date map in order not to get lost.The objective to provide such compass is expressed in the artwork we selected for the cover of this handbook.