International Tables for Crystallography, Volume F, Crystal- lography of Biological Macromolecules, was commissioned by the International Union of Crystallography (IUCr) in recognition of the extraordinary contributions that knowledge of macro- molecular structure has made, and will make, to the analysis of biological systems, from enzyme catalysis to the workings of a whole cell. The volume covers all stages of a crystallographic analysis from the preparation of samples using the techniques of molecular biology and biochemistry, to crystallization, diffraction-data collection, phase determination, structure vali- dation and structure analysis. Although the book is written for experienced scientists, it is recognized that the modern structural biologist is more likely to be a biologist interested in structure than a classical crystallographer interested in biology. Thus, there are chapters on the fundamentals, history and current perspec- tives of macromolecular crystallography, as well as on the avail- ability of useful programs and databases including the Protein Data Bank. Each chapter has been written by an internationally recognized expert.