This volume contains the papers presented at CMSB 2021, the 19th Interna- tional Conference on Computational Methods in Systems Biology, held during September 22–24, 2021 in a hybrid format, allowing for in-person participation in Bordeaux, France, and for online participation.
The CMSB annual conference series, initiated in 2003, provides a unique discussion forum for computer scientists, biologists, mathematicians, engineers, and physicists interested in a system-level understanding of biological processes. Topics covered by the CMSB proceedings include formalisms for modeling biological processes; frameworks for model verification, validation, analysis, and simulation of biological systems; high- performance computational systems biology; model inference from experimental data; multi-scale modeling and analysis methods; computational approaches for synthetic biology; machine learning and data-driven approaches; microbial ecology modeling and analysis; methods and protocols coping with populations and their variability; and models, applications, and case studies in systems and synthetic biology.
There were a total of 54 submissions over the 4 conference tracks (regular papers, tool papers, highlight presentation proposals, and posters). Every regular paper was reviewed by at least three Program Committee members, whereas every tool paper was reviewed by two Program Committee members and two Tool Evaluation Committee members. The latter committee provided a thorough evaluation of the tool quality, in terms of usability, accessibility, reproducibility, and documentation. The committee decided to accept 13 of the 25 submitted regular papers and 5 of the 7 submitted tool papers for publication in this volume and presentation. The conference also included 4 of the 7 proposed highlight presentations and 16 posters not included in the proceedings. The program of CMSB was further enriched by five notorious invited speakers: Diego di Bernardo (TIGEM, Italy), Laurence Calzone (Institut Curie, Paris), Giulia Giodano (University of Trento, Italy), Yang-Yu Liu (Harvard Medical School, USA), and Ion Petre (University of Turku, Finland).