This four-volume set LNCS 5610-5613 constitutes the refereed proceedings of the 13th International Conference on Human-Computer Interaction, HCII 2009, held in San Diego, CA, USA in July 2009, jointly with 8 other thematically similar conferences. The revised papers presented were carefully reviewed and selected from numerous submissions. The papers accepted for presentation thoroughly cover the entire field of Human-Computer Interaction, addressing major advances in knowledge and effective use of computers in a variety of application areas. The papers of the fourth volume are organized in topical sections on elearning and education; games and entertainment; work, collaboration and business; advanced applications.