The two volumes LNCS 4688 and LNBI 4689 constitute the refereed proceedings of the International Conference on Life System Modeling and Simulation, LSMS 2007, held in Shanghai, China, in September 2007.The 147 revised full papers were carefully reviewed and selected from 1383 submissions. The 63 papers of LNCS 4689 are organized in topical sections on modeling and simulation of societies and collective behavior, computational methods and intelligence in biomechanical systems, tissue engineering and clinical bioengineering, computational intelligence in bioinformatics and biometrics, brain stimulation, neural dynamics and neural interfacing, biological and biomedical data integration, mining and visualization, computational methods and intelligence in organism modeling and biochemical networks and regulation, computational methods and intelligence in modeling of molecular, cellular , multi-cellular behavior and design of synthetic biological systems, and others.