The three-volume set, LNCS 2667, LNCS 2668, and LNCS 2669, constitutes the refereed proceedings of the International Conference on Computational Science and Its Applications, ICCSA 2003, held in Montreal, Canada, in May 2003. The three volumes present more than 300 papers and span the whole range of computational science from foundational issues in computer science and mathematics to advanced applications in virtually all sciences making use of computational techniques. The proceedings give a unique account of recent results in computational science.