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Название: Advances in Protein Chemistry, Volume 69: DNA Repair and Replication
Автор: W. Yang (Editor)
The topic of DNA repair, now firmly embedded in the larger field of biological responses to DNA damage, is in an extraordinarily dynamic state at this time. In particular, productive inroads are being made into the central issue of how cells sense the presence of DNA damage and initiate specific signals in response to genomic insult of one type or another. The term‘‘genomicinsult’’isdeliberatelyusedindeferencetothemorefamiliar term ‘‘DNA damage’’ because it is becoming increasingly apparent that the primary event that initiates biological responses to genomic insult may be arrested DNA replication rather than DNA damage itself. This volume, entitledDNARepairandReplication,isthustimelyandappropriatelyfocused. The book comprises eleven chapters contributed by experts in the field. It opens with discussions of the primary modes of the repair of DNA base damage in the strict biochemical sense, namely, base excision repair (BER), enzymatic photoreactivation (EPR) of both cyclobutane pyrimidine dimers and [6–4] photoproducts, nucleotide excision repair (NER), mismatch repair (MMR), and the repair of DNA double-strand breaks (DSBR).