With the rapid development of proteomic technologies in life sciences and in clinical applications, many bioinformatics methodologies, databases, and software tools have been developed to support comparative proteomics study. This volume aims to highlight the current status, challenges, open problems, and future trends in developing bioinformatics tools and resources for comparative proteomics research and to serve as a definitive source of reference providing both the breadth and depth needed on the subject of Bioinformatics for Comparative Proteomics.