This volume constitutes the refereed proceedings of the First International Conference on Reforming Education, Quality of Teaching and Technology Enhanced Learning, TECH-EDUCATION 2010, held in Athens, Greece, in May 2010, as a part of the World Summit on the Knowledge Society Conference Series. The 100 revised full papers presented were carefully reviewed and selected from 194 submissions. The topics addressed include - but are not limited to - quality of the education; technology enhanced learning; strategies for the education of the 21st century; collaborative, constructivist, pedagogical, teaching approaches; formal, informal, professional, corporate and lifelong learning perspectives; the contribution of education to sustainable development.