This book constitutes the refereed proceedings of the Second IFIP TC 13 Human-Computer Interaction Symposium, HCIS 2010, held as part of the 21st World Computer Congress, WCC 2010, in Brisbane, Australia, in September 2010. The 19 revised full papers, 7 short papers, and 5 poster presentations were carefully reviewed and selected from 56 submissions. The papers are organized in topical sections on specification and modeling, user-centered development, usable systems, social and cultural problems, mobile and Web applications, and epistemology, emotions and personalization.