Genome Sequences — Genome Sequence Acquisition and Analysis — Defining Genomes — What Is Genomics? — How Are Whole Genomes Sequenced? — What Is an E-Value? — Why Do the Databases Contain So Many Partial Sequences? — How Do We Make Sense of All These Bases? — Which Draft Sequence Is Better? — Can We Predict Protein Functions? — How Well Are Genes Conserved in Diverse Species? — How Do You Know Which Bases Form a Gene? — How Many Proteins Can One Gene Make? — What Have We Learned from the Human Genome Draft Sequences? — Overview of Human Genome First Draft — Summary Statements — Whose DNA Did We Sequence? — How Do You Fit a Line to Data? — Can We Describe a Typical Human Gene? — When Are the Data Sufficient? — Can the Genome Alter Gene Expression Without Changing the DNA Sequence? — Genome Sequences Answer Interesting Questions — Evolution of Genomes — How Did Eukaryotes Evolve? — Are the Hit Numbers Significantly Different? — What Is the Origin of Our Species? — How Do You Know if the Tree Is Right? — Genomic Identifications — How Can We Identify Biological Weapons? — How Long Can DNA Survive? — How Did Tuberculosis Reach North America? — How Are Newly Emerging Diseases Identified? — Biomedical Genome Research — Can We Use Genomic Sequences to Make New Vaccines? — Can We Make New Types of Antibiotics? — Can We Invent New Types of Medication? — How Can E. coli Be Lethal and in Our Intestines at the Same Time? — How Can You Tell if Base Compositions Are Different? — Genomic Variations