This book constitutes the refereed proceedings of the 6th International Conference on High Performance Computing, HiPC'99, held in Calcutta, India in December 1999. The 20 revised full papers and 40 short papers presented were carefully reviewed and selected from 112 submissions. The papers are organized in sections on architecture/compilers, cluster computing, compilers and tools, scheduling, parallel algorithms, mobile computing, parallel applications, and interconnection networks.