This book constitutes the revised versions of the invited and selected papers from the Second Epistemological Perspectives on Simulation Workshop, EPOS 2006, which was held in Brescia, Italy, during October 5-6, 2006.

The 11 papers presented together with 2 invited papers were carefully reviewed and selected from 35 submissions. The topics addressed were epistemological and methodological contents, such as the relevance of empirical foundations for agent-based simulations, the role of theory, the concepts and meaning of emergence, the trade-off between simplification and complexification of models.