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Matthiesen R. — Bioinformatics Methods in Clinical Research
Matthiesen R. — Bioinformatics Methods in Clinical Research

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Название: Bioinformatics Methods in Clinical Research

Автор: Matthiesen R.

Аннотация:

This book discusses the latest developments in clinical omics research and describes in
detail a subset of the algorithms used in publicly available software tools. The book should
be considered as an omics-bioinformatics resource. However, it is not just a pure bioinformatics
resource filled with complex equations; it describes to some extent the biological
background and also discusses experimental methods. The advantages and drawbacks of
the various experimental methods in relation to data analysis will be reviewed as well. In
other words, the intention is to establish a bridge between theory and practice. Practical
examples showing methods, results, and conclusions from data mining strategies will be
given in some cases. It is not possible to cover all areas of omics techniques and bioinformatics
algorithms in one book. However, an important subset is described and discussed
from both the experimental and the bioinformatics views. The book starts out by discussing
various successful examples in which omics techniques have been used in a clinically
related study. An important buzz word in omics is biomarkers. The word “biomarker”
has different meanings depending on the context in which it is used. Here, it is used in
a clinical context and should be interpreted as “a substance whose specific level indicates
a particular cellular or clinical state.” In theory, one could easily imagine cases where one
biomarker is found at different levels, at different intervals that indicate various states. An
even more complex example would be a set of biomarkers and their corresponding set
of concentration levels, which could be used for classifying a specific cellular or clinical
state. In complex cases, more elaborate models based on machine learning and statistics
are essential for identifying interrelationships between biomarkers


Язык: en

Рубрика: Разное/

Статус предметного указателя: Неизвестно

ed2k: ed2k stats

Год издания: 2010

Количество страниц: 391

Добавлена в каталог: 31.03.2018

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