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Название: Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery (Methods and Principles in Medicinal Chemistry)
Авторы: Wanner K., Hofner G.
For a long time, mass spectrometry in organic chemistry was just used for the
‘‘fingerprint’’ identification of different compounds. Initiated by F.W. McLafferty
and K. Biemann, and largely extended by C. Djerassi, H. Budzikiewicz and D.H.
Williams, sets of structure-specific fragmentation rules were established, which
enabled organic chemists to interpret the chemical structures of their compounds,
even highly complex natural products and drugs. Within a few years, between
1962 and 1964, five books on mass spectrometry of organic compounds
were published, three of them by the Djerassi group. In this manner, Carl Djerassi
made another significant contribution to medicinal chemistry, besides his research
results on optical rotation dispersion and his role in the development of
the ‘‘pill’’. Nowdays, mass spectrometry is well established in drug research, for
the characterization of new compounds, their structure elucidation and structural
confirmation, the identification of drugs and their metabolites in body fluids, and
in anti-doping campaigns.