The four general methods to generate and screen a huge combinatorial pep- tide library (> 1 0 7 peptides) are: biological libraries such as filamentous phage
(1), plasmid (2), or polysome (3) libraries; the "one-bead one-compound" syn-
thetic combIllatonallibrary method or the "SelectIde process" (4-6); synthetic
peptide library methods that require deconvolution, such as an iterative
approach (7,8), posItional scanning (9); orthogonal partition approach (10), or
recurse deconvolution (1I); and synthetic library using affinity column
selection method (12,13).