In vitro utilization of liposomes is now recognized as a powerful tool
in many bioscience investigations and their associated clinical studies,
e.g., liposomes in drug targeting; liposomes in gene transport across plasma
and nuclear membranes; liposomes in enzyme therapy in patients with genetic
disorders. However, before these areas can be effectively explored, many basic
areas in liposome research require elucidation, including: (a) attachment of
liposomes to cell surfaces; (b) permeation of liposomes through the plasma
membranes; and (c) stability of liposomes in cell or nuclear matrices. None of
these areas have been exhaustively explored and liposome researchers have
ample opportunities to contribute to our knowledge.