Biostatistical applications in molecular biology have increased tremendously
in recent years. For example, a search of the Current Index to Statistics
indicates that there were 62 articles published during 1995–1999 that had
“marker” in the title of the article or as a keyword. In contrast, there were 29
such articles in 1990–1994, 17 in 1980–1989, and only 5 in 1970–1979. As the
number of publications has increased, so has the sophistication of the statistical
methods that have been applied in this area of research