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Название: NMDA Receptor Protocols (Methods in Molecular Biology Vol 128)
Автор: Li M.
Ligand-gated ion channels in the brain are a family of membrane receptor
molecules critical to the chemistry of synaptic transmission. Since the synthesis
of N-methyl-D-aspartate by J. C. Watkins in the 1960s, and subsequent pharmacological
studies by a number of groups, NMDA receptors have emerged as key
molecules involved in neuronal excitation and toxicity. The molecular studies of
NMDA receptors began in the late 1980s, thanks to molecular cloning of the
genes encoding various receptor subunits. The ability to express, purify, and
analyze various forms of recombinant NMDA receptor proteins in a variety of
heterologous systems has offered us enormous opportunities for both basic research
of the NMDA receptor structure and function, as well as for clinical investigation
and high-throughput drug screens for bioactive compounds.