This book presents the state of the art in tackling differential equations using advanced methods and software tools of symbolic computation. It focuses on the symbolic-computational aspects of three kinds of fundamental problems in differential equations: transforming the equations, solving the equations, and studying the structure and properties of their solutions. The 20 chapters are written by leading experts and are structured into three parts. The book is worth reading for researchers and students working on this interdisciplinary subject but may also serve as a valuable reference for everyone interested in differential equations, symbolic computation, and their interaction.