The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway.
The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series,
and Avram Hershko has contributed to the opening chapter of the present volume.
Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes.
Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states.
Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.Content:
Chapter 1 Brief History of Protein Degradation and the Ubiquitin System (pages 1–9): Avram Hershko
Chapter 2 N?terminal Ubiquitination: No Longer Such a Rare Modification (pages 10–20): Prof. Dr. Aaron Ciechanover
Chapter 3 Evolutionary Origin of the Activation Step During Ubiquitin?dependent Protein Degradation (pages 21–43): Hermann Schindelin
Chapter 4 RING Fingers and Relatives: Determinators of Protein Fate (pages 44–101): Kevin L. Lorick, Yien?Che Tsai, Yili Yang and Allan M. Weissman
Chapter 5 Ubiquitin?conjugating Enzymes (pages 102–134): Michael J. Eddins and Cecile M. Pickart
Chapter 6 The SCF Ubiquitin E3 Ligase (pages 135–155): Leigh Ann Higa and Hui Zhang
Chapter 7 The Structural Biology of Ubiquitin–Protein Ligases (pages 156–189): Ning Zheng and Nikola P. Pavletich
Chapter 8 The Deubiquitinating Enzymes (pages 190–219): Nathaniel S. Russell and Keith D. Wilkinson
Chapter 9 The 26S Proteasome (pages 220–247): Prof. Dr. Martin Rechsteiner
Chapter 10 Molecular Machines for Protein Degradation (pages 248–287): Matthias Bochtler, Michael Groll, Hans Brandstetter, Tim Clausen and Robert Huber
Chapter 11 Proteasome Regulator, PA700 (19S Regulatory Particle) (pages 288–316): George N. DeMartino and Cezary Wojcik
Chapter 12 Bioinformatics of Ubiquitin Domains and Their Binding Partners (pages 318–347): Kay Hofmann
Chapter 13 The COP9 Signalosome: Its Possible Role in the Ubiquitin System (pages 348–369): Dawadschargal Bech?Otschir, Barbara Kapelari and Wolfgang Dubiel