This helpful, useful, practical book presents the most important achievements in organic chemistry over the past decade, summarizing such major developments as C-H activation, organocatalysis, and supramolecular chemistry. Each chapter contains two or three personal, hitherto unpublished, commentaries by leading experts on the topic. This reference work focuses on four main areas: the total synthesis of natural products and chemical biology; synthetic methodology; physical organic chemistry and chemistry relevant to meeting the urgent needs of humanity. The result is a complete and extremely useful source of a wide variety of information for graduate students, post-docs and researchers.Content:
Chapter 1 Diversity?Oriented Syntheses of Natural Products and Natural Product?Like Compounds (pages 1–31): Ling?Min Xu, Yu?Fan Liang, Qin?Da Ye, Zhen Yang, Michael Foley, Scott A. Snyder and Da?Wei Ma
Chapter 2 Total Synthesis of Natural Products and the Synergy with Synthetic Methodology (pages 33–79): Qian Wang, Jie?Ping Zhu, Kyriacos C. Nicolaou, Henry N. C. Wong and Wei?Dong Li
Chapter 3 Interplay between the Chemical Space and the Biological Space (pages 81–123): Ren?Xiao Wang, Ke Ding, Li?He Zhang and Jun?Ying Yuan
Chapter 4 Biosynthesis of Pharmaceutical Natural Products and Their Pathway Engineering (pages 125–180): Michael J. Smanski, Xu?Dong Qu, Wen Liu, Ben Shen, Yi Tang, Yi Yu and Zi?Xin Deng
Chapter 5 Carbohydrate Synthesis towards Glycobiology (pages 181–219): Biao Yu, Lai?Xi Wang, Sam Danishefsky and David Crich
Chapter 6 Chemical Synthesis of Proteins (pages 221–245): Lei Liu, Sam Danishefsky and David Crich
Chapter 7 CuAAC: The Quintessential Click Reaction (pages 247–277): Valery V. Fokin and Krzysztof Matyjaszewski
Chapter 8 Transition Metal?Catalyzed C?H Functionalization: Synthetically Enabling Reactions for Building Molecular Complexity (pages 279–333): Keary M. Engle, Jin?Quan Yu, Huw M. L. Davies, Zhenfeng Xi, Shu?Li You and Zhang?Jie Shi
Chapter 9 An Overview of Recent Developments in Metal?Catalyzed Asymmetric Transformations (pages 335–366): Christian A. Sandoval, Ryoji Noyori, Qi?Lin Zhou, Andreas Pfaltz, Xue?Long Hou and Hisashi Yamamoto
Chapter 10 The Proline?Catalyzed Mannich Reaction and the Advent of Enamine Catalysis (pages 367–384): Benjamin List, Sai?Hu Liao, Seiji Shirakawa, Keiji Maruoka, Liu?Zhu Gong and Wen?Jing Xiao
Chapter 11 Recent Topics in Cooperative Catalysis: Asymmetric Catalysis, Polymerization, Hydrogen Activation, and Water Splitting (pages 385–412): Motomu Kanai, Takao Ikariya, Takashi Ooi, Prof. Dr. Kuiling Ding and David Milstein
Chapter 12 Flourishing Frontiers in Organofluorine Chemistry (pages 413–476): G. K. Surya Prakash, Fang Wang, David O'Hagan, Jinbo Hu, Prof. Dr. Kuiling Ding and Prof. Dr. Li?Xin Dai
Chapter 13 Supramolecular Organic Chemistry: The Foldamer Approach (pages 477–535): Zhan?Ting Li, Peter J. Stang, Liang Zhao, Mei?Xiang Wang and Chen?Ho Tung
Chapter 14 Novel Catalysis for Alkene Polymerization Mediated by Post?Metallocenes: A Gateway to New Polyalkenes (pages 537–560): Hiromu Kaneyoshi, Haruyuki Makio, Terunori Fujita, Robert Grubbs, Jun Okuda and Eugene Y.?X. Chen
Chapter 15 Chem Is Try Computationally and Experimentally: How Will Computational Organic Chemistry Impact Organic Theories, Mechanisms, and Synthesis in the Twenty?First Century? (pages 561–601): Zhi?Xiang Yu, Yong Liang, K. N. Houk, Yun?Dong Wu and Xin?Hao Zhang
Chapter 16 Case Study of Mechanisms in Synthetic Reactions (pages 603–641): Ai?Wen Lei, Li?Qun Jin, Xin Mu, Guo?Sheng Liu, Qi?Long Shen and Yoshinori Yamamoto
Chapter 17 Organic Materials and Chemistry for Bulk Heterojunction Solar Cells (pages 643–683): Chun?Hui Duan, Fei Huang, Yong Cao, Niyazi Serdar Sariciftci, Yongfang Li, Guillermo C. Bazan and Xiong Gong
Chapter 18 Catalytic Utilization of Carbon Dioxide: Actual Status and Perspectives (pages 685–724): Albert Boddien, Felix Gartner, Christopher Federsel, Irene Piras, Henrik Junge, Ralf Jackstell, Matthias Beller, Gabor Laurenczy and Min Shi
Chapter 19 Synthetic Chemistry with an Eye on Future Sustainability (pages 725–758): Guo?Jun Deng, Chao?Jun Li, Roger A. Sheldon and Tak Hang Chan
Chapter 20 Organic ??Conjugated Molecules for Organic Semiconductors and Photovoltaic Materials (pages 759–780): De?Qing Zhang, Xiao?Wei Zhan, Zhao?Hui Wang, Jian Pei, Guan?Xin Zhang, Dao?Ben Zhu, Seth R. Marder and Tien Yau Luh
Chapter 21 The Future of Organic Chemistry–an Essay (pages 781–789): Ronald Breslow