Providing definitions, clinical features and epidemiology, this handbook and reference adopts a comprehensive approach, describing in detail the various physiological systems involved. As such, it is the first to combine sepsis and non-infectious SIRS, reviewing both the biological and medical aspects of these two important syndromes. The whole is rounded off with a discussion of past, present and future therapies.Content:
Chapter 1 Definition of Sepsis and Non?Infectious SIRS (pages 1–12): Jean?Louis Vincent
Chapter 2 Epidemiology of Sepsis and Non?Infectious SIRS (pages 13–39): Michael C. Reade and Derek C. Angus
Chapter 3 Similarities of the Clinical Aspects of Sepsis and Non?Infectious SIRS (pages 41–55): Anne Claire Lukaszewicz and Didier Payen
Chapter 4 Organ Dysfunctions during Severe Sepsis and Septic?Like Syndromes: Epidemiology, Classification, and Mechanisms (pages 57–76): Olfa Hamzaoui and Jean Carlet
Chapter 5 Pathogens in Sepsis: Gram?Negative Bacterial PAMPs and PRRs (pages 77–108): Andra Schromm, Christian Alexander, Thomas Gutsmann, Jorg Andra and Cordula Stamme
Chapter 6 Pathogens in Sepsis: Gram?Positive Bacterial PAMPs, PRRs and Superantigens (pages 109–143): Christian Alexander, Romney Haylett, Andra Schromm, Ulrich Zahringer and Lothar Rink
Chapter 7 Pathogens in Sepsis: Fungi, Parasites (pages 145–173): Frederic Mechai, Fabrice Bruneel, Fanny Lanternier, Stephane Legriel, Jean?Pierre Bedos and Olivier Lortholary
Chapter 8 Inflammatory Mediators (pages 175–204): Francois Philippart, Prof. Dr. Jean?Marc Cavaillon and Charles Dinarello
Chapter 9 Apoptosis: A Potential Therapeutic Target in Sepsis and Non?Infectious Systemic Inflammation (pages 205–229): Chun?Shiang Chung, Ryan Swan, Mario Perl, Doreen E. Wesche?Soldato and Alfred Ayala
Chapter 10 The Role of Endothelium (pages 231–250): Siew?Yean Lau and Fumito Ichinose
Chapter 11 Coagulation (pages 251–278): Marcel Levi
Chapter 12 Epithelial Barrier Dysfunction as a Mechanism in the Pathogenesis of Multiple Organ Dysfunction (pages 279–297): Mitchell P. Fink, Antonella Cotoia, Donna Beer?Stolz, Shiguang Liu, Penny L. Sappington and Russell L. Delude
Chapter 13 Neural Regulation of Cytokines (pages 299–313): Jared M. Huston and Kevin J. Tracey
Chapter 14 Genetic Polymorphisms and Other Parameters that Affect Predisposal to Infection and Outcome (pages 315–346): Prof. Dr. Jean?Marc Cavaillon and Dr. Christophe Adrie
Chapter 15 Altered Immune Status and Leukocytes Reprogramming (pages 347–371): Prof. Dr. Jean?Marc Cavaillon, Minou Adib?Conquy and Dr. Christophe Adrie
Chapter 16 Experimental Models of Sepsis and Non?Infectious SIRS (pages 373–389): Raghavan Raju, William J. Hubbard and Irshad H. Chaudry
Chapter 17 The Past, Present and Future of Therapies for Sepsis and Non?Infectious Systemic Inflammation (pages 391–416): Nitin Seam and Anthony F. Suffredini