The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceutical science

Physiologically-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the information researchers need to learn these new techniques, its applications are severely limited. Describing the principles, methods, and applications of PBPK modeling as used in pharmaceutics, Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations fills this void.

Connecting theory with practice, the book explores the incredible potential of PBPK modeling for improving drug discovery and development. Comprised of two parts, the book first provides a detailed and systematic treatment of the principles behind physiological modeling of pharmacokinetic processes, inter-individual variability, and drug interactions for small molecule drugs and biologics. The second part looks in greater detail at the powerful applications of PBPK to drug research.

Designed for a wide audience encompassing readers looking for a brief overview of the field as well as those who need more detail, the book includes a range of important learning aids. Featuring end-of-chapter keywords for easy reference?a valuable asset for general or novice readers without a PBPK background?along with an extensive bibliography for those looking for further information, Physiologically- Based Pharmacokinetic (PBPK) Modeling and Simulations is the essential single-volume text on one of the hottest topics in the pharmaceutical sciences today.Content:
Chapter 1 Modeling in the Pharmaceutical Industry (pages 1–12):
Chapter 2 Physiologically?Based Modeling (pages 13–16):
Chapter 3 Review of Pharmacokinetic Principles (pages 17–42):
Chapter 4 Physiological Model for Absorption (pages 43–88):
Chapter 5 Physiological Model for Distribution (pages 89–117):
Chapter 6 Physiological Models for Drug Metabolism and Excretion (pages 119–151):
Chapter 7 Generic Whole?Body Physiologically?Based Pharmacokinetic Modeling (pages 153–159):
Chapter 8 Variability, Uncertainty, and Sensitivity Analysis (pages 161–181):
Chapter 9 Evaluation of Drug–Drug Interaction Risk with PBPK Models (pages 183–207):
Chapter 10 Physiologically?Based Pharmacokinetics of Biotherapeutics (pages 209–259):
Chapter 11 Data Integration and Sensitivity Analysis (pages 261–272):
Chapter 12 Hypothesis Generation and Pharmacokinetic Predictions (pages 273–298):
Chapter 13 Integration of PBPK and Pharmacodynamics (pages 299–382):
Chapter 14 Physiologically?Based Pharmacokinetic Modeling of Populations (pages 383–399):
Chapter 15 PBPK Models along the Drug Discovery and Development Value Chain (pages 401–406):