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Название: Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications, Second Edition
Авторы: Kayser O., Warzecha H.
This second edition of a very successful book is thoroughly updated with existing chapters completely rewritten while the content has more than doubled from 16 to 36 chapters. As with the first edition, the focus is on industrial pharmaceutical research, written by a team of industry experts from around the world, while quality and safety management, drug approval and regulation, patenting issues, and biotechnology fundamentals are also covered. In addition, this new edition now not only includes biotech drug development but also the use of biopharmaceuticals in diagnostics and vaccinations. With a foreword by Robert Langer, Kenneth J Germeshausen Professor of Chemical and Biomedical Engineering at MIT and member of the National Academy of Engineering and the National Academy of Sciences.Content: Chapter 1 Pharmaceutical Biotechnology and Industrial Applications–Learning Lessons from Molecular Biology (pages 1–13): Prof. Dr. Oliver Kayser and Prof. Dr. Heribert Warzecha Chapter 2 Prokaryotic Cells in Biotech Production (pages 15–41): Andriy Luzhetskyy, Gabriele Weitnauer and Andreas Bechthold Chapter 3 Mammalian Cells in Biotech Production (pages 43–57): Maria J. De Jesus and Florian M. Wurm Chapter 4 Biopharmaceuticals from Plants (pages 59–69): Prof. Dr. Heribert Warzecha Chapter 5 Production of Biopharmaceuticals in Transgenic Animals (pages 71–111): Heiner Niemann, Alexander Kind and Angelika Schnieke Chapter 6 Translation of New Technologies in Biomedicines: Shaping the Road from Basic Research to Drug Development and Clinical Application–and Back Again (pages 113–152): Michael Balls, Andrew Bennett and David Kendall Chapter 7 Overview and Classification of Approved Recombinant Drugs (pages 153–178): Theo Dingermann and Ilse Zundorf Chapter 8 Downstream Processing (pages 179–199): Uwe Gottschalk Chapter 9 Characterization of Recombinant Proteins (pages 201–234): Christoph Giese, Henning von Horsten and Stefan Zietze Chapter 10 Formulation Strategies for Recombinant Protein and Related Biotech Drugs (pages 235–256): Gerhard Winter and Julia Myschik Chapter 11 Drug Approval in the European Union and United States (pages 257–267): Gary Walsh Chapter 12 Patents in the Pharmaceutical Biotechnology Industry: Legal and Ethical Issues (pages 269–284): David B. Resnik Chapter 13 Biosimilar Drugs (pages 285–335): Walter Hinderer Chapter 14 Pharmacokinetics and Pharmacodynamics of Therapeutic Peptides and Proteins (pages 337–367): Yi Zhang and Bernd Meibohm Chapter 15 Scientific, Technical, and Economic Aspects of Vaccine Research and Development (pages 369–389): Jens?Peter Gregersen Chapter 16 New Nanobiotechnological Strategies for the Development of Vectors for Cancer Vaccines (pages 391–421): Sean M. Geary, Caitlin D. Lemke, Yogita Krishnamachari and Aliasger K. Salem Chapter 17 Recombinant Vaccines: Development, Production, and Application (pages 423–449): Luke R. Le Grand, Michaela White, Evan B. Siegel and Ross T. Barnard Chapter 18 In Silico and Ultrahigh?Throughput Screenings (uHTS) in Drug Discovery: An Overview (pages 451–490): Debmalya Barh, Shoaib Ahmad and Atanu Bhattacharjee Chapter 19 Metabolic Engineering of Medicinal Plants and Microorganisms for the Production of Natural Products (pages 491–526): Oktavia Hendrawati, Herman J. Woerdenbag, Jacques Hille and Prof. Dr. Oliver Kayser Chapter 20 Metabolomics as a Bioanalytical Tool for Characterization of Medicinal Plants and Their Phytomedical Preparations (pages 527–552): Nizar Happyana, Remco Muntendam and Prof. Dr. Oliver Kayser Chapter 21 Integration of Biotechnologies for the Development of Personalized Medicine (pages 553–580): Kewal K. Jain Chapter 22 Xenotransplantation in Pharmaceutical Biotechnology (pages 581–597): Gregory J. Brunn and Jeffrey L. Platt Chapter 23 Nutraceuticals–Functional Foods for Improving Health and Preventing Disease (pages 599–628): Jian Zhao