Based on the award winning Wiley Encyclopedia of Chemical Biology, this book provides a general overview of the unique features of the small molecules referred to as "natural products", explores how this traditionally organic chemistry-based field was transformed by insights from genetics and biochemistry, and highlights some promising future directions. The book begins by introducing natural products from different origins, moves on to presenting and discussing biosynthesis of various classes of natural products, and then looks at natural products as models and the possibilities of using them in medicine.Content:
Chapter 1 Plant Natural Products (pages 1–29): A. Leslie Gunatilaka
Chapter 2 Marine Natural Products (pages 31–64): Nobuhiro Fusetani
Chapter 3 Microbial Natural Products (pages 65–108): Sergio Sanchez, Silvia Guzman?Trampe, Mariana Avalos, Beatriz Ruiz, Romina Rodriguez?Sanoja and Manuel Jimenez?Estrada
Chapter 4 Nonribosomal Peptides (pages 109–125): Georg Schoenafinger and Mohamed A. Marahiel
Chapter 5 Plant Terpenoids (pages 127–142): Christopher I. Keeling and Jorg Bohlmann
Chapter 6 Polyketides in Fungi (pages 143–161): Thomas J. Simpson and Russell J. Cox
Chapter 7 Modular Polyketide Synthases (pages 163–187): Tonia J. Buchholz, Jeffrey D. Kittendorf and David H. Sherman
Chapter 8 Polyketide Polyethers (pages 189–207): Alison M. Hill
Chapter 9 Alkaloids (pages 209–237): Sarah E. O'Connor
Chapter 10 Cofactors (pages 239–267): Ilka Haase, Markus Fischer, Adelbert Bacher, Wolfgang Eisenreich and Felix Rohdich
Chapter 11 Antibiotics (pages 269–285): Sergey B. Zotchev
Chapter 12 Pharmaceuticals: Natural Products and Natural Product Models (pages 287–324): Sheo B. Singh
Chapter 13 Natural Products as Anticancer Agents (pages 325–349): David G. I. Kingston and David J. Newman
Chapter 14 Plant?Derived Natural Products Research in Drug Discovery (pages 351–388): Kuo?Hsiung Lee, Hideji Itokawa, Toshiyuki Akiyama and Susan L. Morris?Natschke