A definitive, single source of information on PBPK modeling
Physiologically-based pharmacokinetic (PBPK) modeling is becoming increasingly important in human health risk assessments and in supporting pharmacodynamic modeling for toxic responses. Organized by classes of compounds and modeling purposes so users can quickly access information, this is the first comprehensive reference of its kind.
This book presents an overview of the underlying principles of PBPK model development. Then it provides a compendium of PBPK modeling information, including historical development, specific modeling challenges, and current practices for:
* Halogenated Alkanes
* Halogenated Alkenes
* Alkene and Aromatic Compounds
* Reactive Vapors in the Nasal Cavity
* Alkanes, Oxyhydrocarbons, and Related Compounds
* Pesticides and Persistent Organic Pollutants
* Dioxin and Related Compounds
* Metals and Inorganic Compounds
* Drugs
* Antineoplastic Agents
* Perinatal Transfer
* Mixtures
* Dermal Exposure Models
In addition to pinpointing specific information, readers can explore diverse modeling techniques and applications. An authoritative reference for toxicologists, ecotoxicologists, risk assessors, regulators, pharmacologists, pharmacists, and graduate students in pharmacokinetics and toxicology, Physiologically-Based Pharmacokinetic Modeling compiles information from leaders in the field and discusses future directions for PBPK modeling.Content:
Chapter 1 Introduction: A Historical Perspective of the Development and Applications of PBPK Models (pages 1–18): Melvin E. Andersen, Raymond S. H. Yang, Harvey J. Clewell and Micaela B. Reddy
Chapter 2 Halogenated Alkanes (pages 19–54): Micaela B. Reddy, Ivan D. Dobrev and James E. Dennison
Chapter 3 Halogenated Alkenes (pages 55–78): Dong?Soon Bae, Melvin E. Andersen and Harvey J. Clewell
Chapter 4 Alkene and Aromatic Compounds (pages 79–117): James E. Dennison
Chapter 5 Reactive Vapors in the Nasal Cavity (pages 119–140): James E. Dennison and Melvin E. Andersen
Chapter 6 Alkanes, Oxyhydrocarbons and Related Compounds (pages 141–166): Robert T. Davidson and Micaela B. Reddy
Chapter 7 Pesticides and Persistent Organic Pollutants (POPs) (pages 167–205): Carol J. Belfiore
Chapter 8 Dioxin and Related Compounds (pages 207–237): Yasong Lu
Chapter 9 Metals and Inorganic Compounds (pages 239–270): Julie Campain
Chapter 10 Drugs (pages 271–296): Tami S. McMullin
Chapter 11 Antineoplastic Agents (pages 297–317): Wendy Pott O'brien
Chapter 12 Perinatal Pharmacokinetics (pages 319–347): Sun K. Lee
Chapter 13 Mixtures (pages 349–373): Raymond S. H. Yang and Melvin E. Andersen
Chapter 14 Dermal Exposure Models (pages 375–387): Micaela B. Reddy
Chapter 15 Conclusions and Future Directions (pages 389–399): Melvin E. Andersen, Micaela B. Reddy, Harvey J. Clewell and Raymond S. H. Yang