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Wainer I., Józwiak K., Lough W. — Drug stereochemistry: analytical methods and pharmacology
Wainer I., Józwiak K., Lough W. — Drug stereochemistry: analytical methods and pharmacology

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Название: Drug stereochemistry: analytical methods and pharmacology

Авторы: Wainer I., Józwiak K., Lough W.


The first half of the nineteenth century was the great age of geometrical optics.
Several French scientists studied diffraction, interference, and polarization of
light. In particular, linear polarization of light and rotation of the plane of
polarization very quickly attracted attention because of the possible relationship
between these phenomena and the structure of matter. Optical activity, the
ability of a substance to rotate the plane of polarization of light, was discovered
in 1815 at the College de France by the physicist Jean-Baptiste Biot. In 1848 at the
Ecole Normale in Paris, Louis Pasteur made a set of observations that led him a
few years later to make this proposal, which is the foundation of stereochem￾istry: Optical activity of organic solutions is determined by molecular asymme￾try, which produces nonsuperimposable mirror-image structures. A logical
extension of this idea occurred in 1874 when a theory of organic structure in
three dimensions was advanced independently and almost simultaneously by
Jacobus Henricus van’t Hoff in Holland and Joseph Achille Le Bel in France. By
this time it was known from the work of Kekule in 1858 that carbon is tetravalent
(links up with four other groups or atoms). van’t Hoff and Le Bel proposed that
the four valances of the carbon atom were not planar, but directed into three￾dimensional space. van’t Hoff specifically proposed that the spatial arrangement
was tetrahedral. A compound containing a carbon substituted with four differ￾ent groups, which van’t Hoff defined as an asymmetric carbon (asymmetrisch
koolstof-atoom), would therefore be capable of existing in two distinctly different
nonsuperimposable forms. The asymmetric carbon atom, they proposed, was
the cause of molecular asymmetry and therefore optical activity

Язык: en

Рубрика: Разное/

Статус предметного указателя: Неизвестно

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Издание: 2nd

Год издания: 2012

Количество страниц: 424

Добавлена в каталог: 18.06.2017

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