The earliest descriptions of human chromosomes in the late 1800s by Arnold and Flemming
were the beginning of the genomics revolution now upon us. This book on “Array
Comparative Genomic Hybridization: Protocols and Applications” explores the scope of
what is now possible in documenting abnormalities associated with several types of human
cancers. While the technology for interrogating the human genome continues to evolve,
re fi nement of comparative genomic hybridization (CGH) using array CGH and related
technologies have provided enormous insight into human cancers at an affordable scale in
research and clinical laboratories.